What is Acetaminophen/Caffeine?
Acetaminophen/Caffeine contains a combination of Acetaminophen/Caffeine, aspirin, and caffeine. Acetaminophen/Caffeine is a pain reliever and a fever reducer. Aspirin is in a group of drugs called salicylates. It works by reducing substances in the body that cause pain, fever, and inflammation. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.
Acetaminophen/Caffeine is used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, or nasal congestion.
Acetaminophen/Caffeine may also be used for purposes not listed in this medication guide.
Acetaminophen/Caffeine indications
This medication contains a combination of Acetaminophen/Caffeine, aspirin, and caffeine. Acetaminophen/Caffeine is a pain reliever and a fever reducer. Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.
This medication is used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, or nasal congestion.
Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.
How should I use Acetaminophen/Caffeine?
Use Acetaminophen/Caffeine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Acetaminophen/Caffeine may be taken with or without food.
- If you miss a dose of Acetaminophen/Caffeine and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Acetaminophen/Caffeine.
Uses of Acetaminophen/Caffeine in details
Use: Labeled Indications
Pain: For the temporary relief of pain caused by headache or muscle aches
Acetaminophen/Caffeine description
Each caplet contains Acetaminophen/Caffeine 500 mg and caffeine 65 mg.
Acetaminophen/Caffeine dosage
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Tablet,
Oral:
Acetaminophen/Caffeine Tension Headache: Acetaminophen/Caffeine 500 mg and caffeine 65 mg [contains benzoic acid, brilliant blue fcf (fd&c blue #1), fd&c red #40, fd&c yellow #6 (sunset yellow)]
Acetaminophen/Caffeine Tension Headache: Acetaminophen/Caffeine 500 mg and caffeine 65 mg [DSC] [contains benzoic acid, fd&c blue #1 aluminum lake, fd&c red #40, fd&c yellow #10 aluminum lake]
Acetaminophen/Caffeine Tension Headache: Acetaminophen/Caffeine 500 mg and caffeine 65 mg [aspirin free; contains benzoic acid, fd&c blue #1 aluminum lake, fd&c red #40]
Acetaminophen/Caffeine Tension Headache: Acetaminophen/Caffeine 500 mg and caffeine 65 mg [DSC] [aspirin free; contains fd&c blue #2 aluminum lake, fd&c yellow #6 aluminum lake]
Dosing: Adult
Pain:
Oral: Acetaminophen/Caffeine 1 g/caffeine 130 mg every 6 hours as needed (maximum: Acetaminophen/Caffeine 3 g/caffeine 390 mg per 24 hours)
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Pain: Children ≥12 years and Adolescents: Refer to adult dosing.
Acetaminophen/Caffeine interactions
See also:
What other drugs will affect Acetaminophen/Caffeine?
Acetaminophen/Caffeine is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Acetaminophen/Caffeine [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Acetaminophen/Caffeine and may decrease the action of Acetaminophen/Caffeine. Doses of Acetaminophen/Caffeine greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Acetaminophen/Caffeine to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
Cholestyramine (Questran) reduces the effect of Acetaminophen/Caffeine by decreasing its absorption into the body from the intestine. Therefore, Acetaminophen/Caffeine should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.
Acetaminophen/Caffeine doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Acetaminophen/Caffeine should be avoided during warfarin therapy
Acetaminophen/Caffeine side effects
See also:
What are the possible side effects of Acetaminophen/Caffeine?
Get emergency medical help if you have any of these signs of an allergic reaction to Acetaminophen/Caffeine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:
weakness or fainting;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
severe nausea, vomiting, or stomach pain;
redness or swelling;
low fever with nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever lasting longer than 3 days;
pain lasting longer than 10 days; or
hearing problems, ringing in your ears.
Less serious side effects may include:
upset stomach, heartburn;
feeling nervous or excited; or
sleep problems (insomnia).
Acetaminophen/Caffeine contraindications
See also:
What is the most important information I should know about Acetaminophen/Caffeine?
This medicaion should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin in this medicine can cause a serious and sometimes fatal condition called Reye’s syndrome in children. You should not use this if you are allergic to Acetaminophen/Caffeine (Tylenol), aspirin, or caffeine, or if you have:
a recent history of stomach or intestinal bleeding;
liver disease;
asthma or severe allergic reaction caused by taking aspirin or a non-steroidal anti-inflammatory drug (NSAID), especially "aspirin triad syndrome"; or
if you are allergic to an NSAID such as Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:
asthma or seasonal allergies;
fever with a stiff neck;
a stomach ulcer, heartburn, or stomach pain;
a bleeding or blood clotting disorder such as hemophilia;
diabetes; or
gout.
Active ingredient matches for Acetaminophen/Caffeine:
Acetaminophen/Caffeine
List of Acetaminophen/Caffeine substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Acetaminophen/ caffeine | |
| Acetaminophen; Caffeine | |
| Tablet; Oral; Acetaminophen 500 mg; Caffeine 65 mg | |
| Tablets; Oral; Acetaminophen 500 mg; Caffeine 65 mg | |
| Andrews Answer (United Kingdom) | |
| Aspirin Free Excedrin (United States) | |
| Aspirin-Free Bayer Select Headache (United States) | |
| Atamel Compositum | |
| Bayer Select Headache Pain Rel | |
| Bayer Select Maximum Strength Headache (United States) | |
| Cafadol (United Kingdom) | |
| Cafersona (Spain) | |
| Cefaline Hauth | |
| Cerebrol ohne Codein | |
| Cerebrol sans Codeine (Switzerland) | |
| Cetafeine (France) | |
| Claradol Cafeine | |
| Tablet, Effervescent; Oral; Acetaminophen 500 mg; Caffeine 50 mg | |
| Tablet; Oral; Acetaminophen 500 mg; Caffeine 50 mg | |
| Coffalon N (Germany) | |
| Tablet; Oral; Acetaminophen; Caffeine (Stark) | |
| De Witt's Analgesic | |
| Ditonal N (Germany) | |
| Elcodrix (Brazil) | |
| Excedrin | |
| Tablet; Oral; Acetaminophen 325 mg; Caffeine 65 mg (Bms) | |
| Excedrin Aspirin-Free | |
| Excedrin Mild Headache | |
| Excedrin Quick Tab | |
| Excedrin Quick Tab Peppermint | |
| Excedrin Quick Tab Spearmint | |
| Excedrin QuickTabs (United States) | |
| Excedrin Tension Headache | |
| Tablet; Oral; Acetaminophen 500 mg; Caffeine 65 mg (Novartis) | |
| Excedrin Tension Headache Caplet | |
| Excedrin Tension Headache Express Gels | |
| Excedrin Tension Headache Geltab | |
| Fevadol Extra | |
| Headache Relief | |
| Kafa plus Cafeine (Switzerland) | |
| Lemsip Max Relief | |
| Capsule; Oral; Acetaminophen; Caffeine | |
| Mejoral Plus (Mexico) | |
| Tablet; Oral; Acetaminophen 500 mg; Caffeine 65 mg (Gsk) | |
| Mejoral with Caffeine | |
| Tablet; Oral; Acetaminophen 500 mg; Caffeine 65 mg | |
| Midol Menstrual Headache | |
| Caplet; Oral; Acetaminophen 500 mg; Caffeine 65 mg | |
| Migrenol (Poland) | |
| Tablet, Film-Coated; Oral; Acetaminophen 500 mg; Caffeine 65 mg (Sanofi-aventis) | |
| Neopyrin Forte | |
| Capsule; Oral; Acetaminophen; Caffeine | |
| Neuramag P (Germany) | |
See 70 substitutes for Acetaminophen/Caffeine | |
References
- DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "caffeine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Acetaminophen/Caffeine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Acetaminophen/Caffeine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
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Information checked by Dr. Sachin Kumar, MD Pharmacology
