What is Amlodipine 5MG TABLET?
Amlodipine 5MG TABLET is used alone or together with other medicines to treat angina (chest pain) and high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Amlodipine 5MG TABLET is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. As a result, Amlodipine 5MG TABLET relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.
Amlodipine 5MG TABLET is available only with your doctor's prescription.
Amlodipine 5MG TABLET indications
Hypertension: Amlodipine 5MG TABLET is indicated for the first-line treatment of hypertension and can be used as the sole agent to control blood pressure in the majority of patients. Patients not adequately controlled on a single antihypertensive agent may benefit from the addition of Amlodipine 5MG TABLET, which has been used in combination with a thiazide diuretic, β-adrenoceptor-blocking agent or an angiotensin-converting enzyme inhibitor.
Amlodipine 5MG TABLET is also indicated to reduce the risk of fatal coronary heart disease (CHD) and non-fatal myocardial infarction (MI), and to reduce the risk of stroke.
Coronary Artery Disease: Amlodipine 5MG TABLET is indicated to reduce the risk of coronary revascularization and the need for hospitalization due to angina in patients with coronary artery disease (CAD).
Chronic Stable Angina: Amlodipine 5MG TABLET is indicated for the first-line treatment of myocardial ischemia, whether due to fixed obstruction (stable angina) and/or vasospasm/vasoconstriction (Prinzmetal’s or variant angina) of coronary vasculature. Amlodipine 5MG TABLET may be used where the clinical presentation suggests a possible vasospastic/vasoconstrictive component but where vasospasm/vasoconstriction has not been confirmed. Amlodipine 5MG TABLET may be used alone, as monotherapy, or in combination with other antianginal drugs in patients with angina that is refractory to nitrates and/or adequate doses of beta-blockers.
How should I use Amlodipine 5MG TABLET?
Use Amlodipine 5MG TABLET as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Amlodipine 5MG TABLET. Talk to your pharmacist if you have questions about this information.
- Take Amlodipine 5MG TABLET by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Taking Amlodipine 5MG TABLET at the same time each day will help you remember to take it.
- Continue to take Amlodipine 5MG TABLET even if you feel well. Do not miss any doses.
- If you miss a dose of Amlodipine 5MG TABLET, take it as soon as possible. If it has been more than 12 hours since you missed your last dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Amlodipine 5MG TABLET.
Uses of Amlodipine 5MG TABLET in details
This medication is used along with other treatment for certain blood vessel diseases (e.g., arteriosclerosis obliterans, Raynaud's disease, Buerger's disease, cerebrovascular insufficiency). It works by widening blood vessels to help increase blood flow (improve circulation) to certain parts of the body (e.g., hands/feet, brain). This effect may help to decrease symptoms such as cold hands and feet, numbness, tingling, and decreased memory or judgment.
How to use Amlodipine 5MG TABLET
This medication is taken by mouth with or without food, usually 3 to 4 times daily or as directed by your doctor. Dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
Tell your doctor if your condition persists or worsens.
Amlodipine 5MG TABLET description
Each 5-mg and 10-mg tablet contains Amlodipine besilate equivalent to Amlodipine 5MG TABLET 5 mg and 10 mg, respectively.
Amlodipine 5MG TABLET also contains the following excipients: Calcium hydrogen phosphate anhydrous, microcrystalline cellulose, magnesium stearate, sodium starch glycollate.
Amlodipine 5MG TABLET besilate is the besilate salt of Amlodipine 5MG TABLET, a long-acting calcium-channel blocker. It is 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulphonate. Its empirical formula is C20H25ClN2O5·C6H6O3S and has a molecular weight of 567.1.
Amlodipine 5MG TABLET besilate is a white crystalline powder and is slightly soluble in water and sparingly soluble in ethanol.
Amlodipine 5MG TABLET dosage
For both hypertension and angina, the usual initial dose is 5 mg Amlodipine 5MG TABLET once daily, which may be increased to a maximum dose of 10 mg depending on the individual patient's response.
For patients with coronary artery disease, the recommended dosage range is 5 mg to 10 mg once daily. In clinical studies, the majority of patients required 10 mg once daily.
No dose adjustment of Amlodipine 5MG TABLET is required upon concomitant administration of thiazide diuretics, beta-blockers, and ACE inhibitors.
Amlodipine 5MG TABLET ODT: For Amlodipine 5MG TABLET orodispersible tablets, the patient should place the tablet on the tongue and allow it to dissolve.
Elderly: Normal dosage regimens are recommended. Amlodipine 5MG TABLET, used at similar doses in the elderly or younger patients, is equally well-tolerated.
Children: Safety and effectiveness of Amlodipine 5MG TABLET in children have not been established.
Patients with Impaired Hepatic Function: See Precautions.
Patients with Renal Failure: Amlodipine 5MG TABLET may be used at normal doses in patients with renal failure.
Changes in Amlodipine 5MG TABLET plasma concentrations are not correlated with the degree of renal impairment. Amlodipine 5MG TABLET is not dialyzable.
Amlodipine 5MG TABLET interactions
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What other drugs will affect Amlodipine 5MG TABLET?
In vitro data in human plasma indicate that Amlodipine 5MG TABLET has no effect on the protein-binding of drugs tested (digoxin, phenytoin, warfarin and indomethacin).
Special Studies: Effect of Other Agents on Amlodipine 5MG TABLET:
Cimetidine: Co-administration of Amlodipine 5MG TABLET with cimetidine did not alter the pharmacokinetics of Amlodipine 5MG TABLET.
Grapefruit Juice: Co-administration of 240 mL of grapefruit juice with a single oral dose of Amlodipine 5MG TABLET 10 mg in 20 healthy volunteers had no significant effect on the pharmacokinetics of Amlodipine 5MG TABLET.
Antacid: Co-administration of antacid with a single dose of Amlodipine 5MG TABLET had no significant effect on the pharmacokinetics of Amlodipine 5MG TABLET.
Sildenafil: A single 100-mg dose of sildenafil in subjects with essential hypertension had no effect on the pharmacokinetic parameters of Amlodipine 5MG TABLET. When Amlodipine 5MG TABLET and sildenafil were used in combination, each agent independently exerted its own blood pressure-lowering effect.
Effect of Amlodipine 5MG TABLET on Other Agents: Atorvastatin: Co-administration of multiple 10-mg doses of Amlodipine 5MG TABLET with 80 mg of atorvastatin resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.
Digoxin: Co-administration of Amlodipine 5MG TABLET with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers.
Ethanol (alcohol): Single and multiple 10-mg doses of Amlodipine 5MG TABLET had no significant effect on the pharmacokinetics of ethanol.
Warfarin: Co-administration of Amlodipine 5MG TABLET with warfarin did not change the warfarin prothrombin response time.
In clinical trials, Amlodipine 5MG TABLET has been safely administered with thiazide diuretics, β-blockers, ACE inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, NSAIDs, antibiotics and oral hypoglycemic drugs.
Drug/Laboratory Test Interactions: None known.
Amlodipine 5MG TABLET side effects
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What are the possible side effects of Amlodipine 5MG TABLET?
The most common adverse effects of Amlodipine 5MG TABLET besilate, similar to that of other calcium-channel blockers, are associated with its vasodilating effects are often lessened with continued use of the drug. Among them are flushing, headache disorders, dizziness and peripheral edema, the most common of which are edema and flushing which are due to the vasodilating effect of Amlodipine 5MG TABLET.
Abdominal pain with cramps, fatigue, palpitations, tachycardia and nausea are less frequently experienced with the use of Amlodipine 5MG TABLET.
Other adverse effects associated with the use of Amlodipine 5MG TABLET include increased micturition, eye pain and other visual disturbances, mental or mood changes eg, depression, anxiety or nervousness, decreased sexual ability/desire, constipation and fainting.
At the start of the treatment, a paradoxical increase in ischemic chest pain may be experienced. In some patients, cerebral or myocardial ischemia or transient blindness caused by excessive fall in blood pressure occur. Amlodipine 5MG TABLET, in 1 study was found to induce gingival overgrowth.
Hypersensitivity reactions to Amlodipine 5MG TABLET may occur leading to rashes, including erythema multiforme, fever and abnormal liver functions eg, cholestasis. Other symptoms of allergic reactions are itching, swelling, severe dizziness and trouble breathing.
Amlodipine 5MG TABLET contraindications
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What is the most important information I should know about Amlodipine 5MG TABLET?
Before taking Amlodipine 5MG TABLET, tell your doctor if you have congestive heart failure or liver disease.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Amlodipine 5MG TABLET.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Amlodipine 5MG TABLET is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.
Tell your doctor about all other heart or blood pressure medications you are taking.
Your chest pain may become worse when you first start taking Amlodipine 5MG TABLET or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.
Active ingredient matches for Amlodipine 5MG TABLET:
| Unit description / dosage (Manufacturer) | Price, USD |
| AMLODIPINE 5MG TABLET 1 strip / 10 tablets each (Jan Aushadhi) | $ 0.04 |
List of Amlodipine 5MG TABLET substitutes (brand and generic names): | |
| Amlodipine/Valsartan Inteli (Lithuania) | |
| Amlodipinebesilaat CF (Netherlands) | |
| Amlodipinebesilaat STADA (Netherlands) | |
| Amlodipinemaleaat | |
| Tablet; Oral; Amlodipine Maleate 10 mg | |
| Tablet; Oral; Amlodipine Maleate 5 mg | |
| Amlodipinemesilaat CF (Netherlands) | |
| Amlodipinmaleat | |
| Tablet; Oral; Amlodipine Maleate 10 mg | |
| Tablet; Oral; Amlodipine Maleate 5 mg | |
| Amlodipino (Colombia, Ecuador, Peru) | |
| Tablet; Oral; Amlodipine 10 mg | |
| Tablet; Oral; Amlodipine 5 mg | |
| Amlodipino 1A Farma (Spain) | |
| Amlodipino 5mg La Sante (Paraguay) | |
| Amlodipino A-Z (Colombia) | |
| Amlodipino Acebex (Spain) | |
| Amlodipino Acost (Spain) | |
| Amlodipino Actavis (Spain) | |
| Amlodipino Almus (Spain) | |
| Amlodipino Alter (Spain) | |
| Amlodipino Angenerico (Spain) | |
| Amlodipino Apotex (Spain) | |
| Amlodipino Arafarma Group (Spain) | |
| Amlodipino Argenol (Spain) | |
| Amlodipino Aristo (Spain) | |
| Amlodipino Ascend (Chile) | |
| Amlodipino Aurobindo (Spain) | |
| Amlodipino Aurovitas (Spain) | |
| Amlodipino BD-Mabo (Spain) | |
| Amlodipino Belmac (Spain) | |
| Amlodipino Besilato (Peru) | |
| Amlodipino Bexal (Spain) | |
| Amlodipino Bexalabs (Spain) | |
| Amlodipino Biogen (Colombia) | |
| Amlodipino Blaskov (Colombia) | |
| Amlodipino Bluefish (Spain) | |
| Amlodipino Bussié (Colombia) | |
| Amlodipino Chemopharma (Chile) | |
| Amlodipino Cinfa (Spain) | |
| Amlodipino Colmed (Colombia) | |
| Amlodipino Combix (Spain) | |
| Amlodipino Comprimidos Biosan (Chile) | |
| Amlodipino Cuvefarma (Spain) | |
| Amlodipino Davur (Spain) | |
See 4039 substitutes for Amlodipine 5MG TABLET | |
References
- PubChem. "amlodipine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "amlodipine". http://www.drugbank.ca/drugs/DB00381 (accessed September 17, 2018).
- MeSH. "Antihypertensive Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
