What is Amlodipino Aurovitas?
Amlodipino Aurovitas is used alone or together with other medicines to treat angina (chest pain) and high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Amlodipino Aurovitas is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. As a result, Amlodipino Aurovitas relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.
Amlodipino Aurovitas is available only with your doctor's prescription.
Amlodipino Aurovitas indications
Hypertension: Amlodipino Aurovitas is indicated for the first-line treatment of hypertension and can be used as the sole agent to control blood pressure in the majority of patients. Patients not adequately controlled on a single antihypertensive agent may benefit from the addition of Amlodipino Aurovitas, which has been used in combination with a thiazide diuretic, β-adrenoceptor-blocking agent or an angiotensin-converting enzyme inhibitor.
Amlodipino Aurovitas is also indicated to reduce the risk of fatal coronary heart disease (CHD) and non-fatal myocardial infarction (MI), and to reduce the risk of stroke.
Coronary Artery Disease: Amlodipino Aurovitas is indicated to reduce the risk of coronary revascularization and the need for hospitalization due to angina in patients with coronary artery disease (CAD).
Chronic Stable Angina: Amlodipino Aurovitas is indicated for the first-line treatment of myocardial ischemia, whether due to fixed obstruction (stable angina) and/or vasospasm/vasoconstriction (Prinzmetal’s or variant angina) of coronary vasculature. Amlodipino Aurovitas may be used where the clinical presentation suggests a possible vasospastic/vasoconstrictive component but where vasospasm/vasoconstriction has not been confirmed. Amlodipino Aurovitas may be used alone, as monotherapy, or in combination with other antianginal drugs in patients with angina that is refractory to nitrates and/or adequate doses of beta-blockers.
How should I use Amlodipino Aurovitas?
Use Amlodipino Aurovitas as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Amlodipino Aurovitas. Talk to your pharmacist if you have questions about this information.
- Take Amlodipino Aurovitas by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Taking Amlodipino Aurovitas at the same time each day will help you remember to take it.
- Continue to take Amlodipino Aurovitas even if you feel well. Do not miss any doses.
- If you miss a dose of Amlodipino Aurovitas, take it as soon as possible. If it has been more than 12 hours since you missed your last dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Amlodipino Aurovitas.
Uses of Amlodipino Aurovitas in details
This medication is used along with other treatment for certain blood vessel diseases (e.g., arteriosclerosis obliterans, Raynaud's disease, Buerger's disease, cerebrovascular insufficiency). It works by widening blood vessels to help increase blood flow (improve circulation) to certain parts of the body (e.g., hands/feet, brain). This effect may help to decrease symptoms such as cold hands and feet, numbness, tingling, and decreased memory or judgment.
How to use Amlodipino Aurovitas
This medication is taken by mouth with or without food, usually 3 to 4 times daily or as directed by your doctor. Dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
Tell your doctor if your condition persists or worsens.
Amlodipino Aurovitas description
Each 5-mg and 10-mg tablet contains Amlodipine besilate equivalent to Amlodipino Aurovitas 5 mg and 10 mg, respectively.
Amlodipino Aurovitas also contains the following excipients: Calcium hydrogen phosphate anhydrous, microcrystalline cellulose, magnesium stearate, sodium starch glycollate.
Amlodipino Aurovitas besilate is the besilate salt of Amlodipino Aurovitas, a long-acting calcium-channel blocker. It is 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulphonate. Its empirical formula is C20H25ClN2O5·C6H6O3S and has a molecular weight of 567.1.
Amlodipino Aurovitas besilate is a white crystalline powder and is slightly soluble in water and sparingly soluble in ethanol.
Amlodipino Aurovitas dosage
For both hypertension and angina, the usual initial dose is 5 mg Amlodipino Aurovitas once daily, which may be increased to a maximum dose of 10 mg depending on the individual patient's response.
For patients with coronary artery disease, the recommended dosage range is 5 mg to 10 mg once daily. In clinical studies, the majority of patients required 10 mg once daily.
No dose adjustment of Amlodipino Aurovitas is required upon concomitant administration of thiazide diuretics, beta-blockers, and ACE inhibitors.
Amlodipino Aurovitas ODT: For Amlodipino Aurovitas orodispersible tablets, the patient should place the tablet on the tongue and allow it to dissolve.
Elderly: Normal dosage regimens are recommended. Amlodipino Aurovitas, used at similar doses in the elderly or younger patients, is equally well-tolerated.
Children: Safety and effectiveness of Amlodipino Aurovitas in children have not been established.
Patients with Impaired Hepatic Function: See Precautions.
Patients with Renal Failure: Amlodipino Aurovitas may be used at normal doses in patients with renal failure.
Changes in Amlodipino Aurovitas plasma concentrations are not correlated with the degree of renal impairment. Amlodipino Aurovitas is not dialyzable.
Amlodipino Aurovitas interactions
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What other drugs will affect Amlodipino Aurovitas?
In vitro data in human plasma indicate that Amlodipino Aurovitas has no effect on the protein-binding of drugs tested (digoxin, phenytoin, warfarin and indomethacin).
Special Studies: Effect of Other Agents on Amlodipino Aurovitas:
Cimetidine: Co-administration of Amlodipino Aurovitas with cimetidine did not alter the pharmacokinetics of Amlodipino Aurovitas.
Grapefruit Juice: Co-administration of 240 mL of grapefruit juice with a single oral dose of Amlodipino Aurovitas 10 mg in 20 healthy volunteers had no significant effect on the pharmacokinetics of Amlodipino Aurovitas.
Antacid: Co-administration of antacid with a single dose of Amlodipino Aurovitas had no significant effect on the pharmacokinetics of Amlodipino Aurovitas.
Sildenafil: A single 100-mg dose of sildenafil in subjects with essential hypertension had no effect on the pharmacokinetic parameters of Amlodipino Aurovitas. When Amlodipino Aurovitas and sildenafil were used in combination, each agent independently exerted its own blood pressure-lowering effect.
Effect of Amlodipino Aurovitas on Other Agents: Atorvastatin: Co-administration of multiple 10-mg doses of Amlodipino Aurovitas with 80 mg of atorvastatin resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.
Digoxin: Co-administration of Amlodipino Aurovitas with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers.
Ethanol (alcohol): Single and multiple 10-mg doses of Amlodipino Aurovitas had no significant effect on the pharmacokinetics of ethanol.
Warfarin: Co-administration of Amlodipino Aurovitas with warfarin did not change the warfarin prothrombin response time.
In clinical trials, Amlodipino Aurovitas has been safely administered with thiazide diuretics, β-blockers, ACE inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, NSAIDs, antibiotics and oral hypoglycemic drugs.
Drug/Laboratory Test Interactions: None known.
Amlodipino Aurovitas side effects
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What are the possible side effects of Amlodipino Aurovitas?
The most common adverse effects of Amlodipino Aurovitas besilate, similar to that of other calcium-channel blockers, are associated with its vasodilating effects are often lessened with continued use of the drug. Among them are flushing, headache disorders, dizziness and peripheral edema, the most common of which are edema and flushing which are due to the vasodilating effect of Amlodipino Aurovitas.
Abdominal pain with cramps, fatigue, palpitations, tachycardia and nausea are less frequently experienced with the use of Amlodipino Aurovitas.
Other adverse effects associated with the use of Amlodipino Aurovitas include increased micturition, eye pain and other visual disturbances, mental or mood changes eg, depression, anxiety or nervousness, decreased sexual ability/desire, constipation and fainting.
At the start of the treatment, a paradoxical increase in ischemic chest pain may be experienced. In some patients, cerebral or myocardial ischemia or transient blindness caused by excessive fall in blood pressure occur. Amlodipino Aurovitas, in 1 study was found to induce gingival overgrowth.
Hypersensitivity reactions to Amlodipino Aurovitas may occur leading to rashes, including erythema multiforme, fever and abnormal liver functions eg, cholestasis. Other symptoms of allergic reactions are itching, swelling, severe dizziness and trouble breathing.
Amlodipino Aurovitas contraindications
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What is the most important information I should know about Amlodipino Aurovitas?
Before taking Amlodipino Aurovitas, tell your doctor if you have congestive heart failure or liver disease.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Amlodipino Aurovitas.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Amlodipino Aurovitas is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.
Tell your doctor about all other heart or blood pressure medications you are taking.
Your chest pain may become worse when you first start taking Amlodipino Aurovitas or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.
Active ingredient matches for Amlodipino Aurovitas:
Amlodipine in Spain.
List of Amlodipino Aurovitas substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Amlodipino Zentiva (Spain) | |
| Amlodipinum (Poland) | |
| Amlodipinum 123ratio (Poland) | |
| Amlodipinum Tad (Poland) | |
| Amlodipress 1A Pharma (Hungary) | |
| Amlodis (Tunisia, Turkey) | |
| Amlodis 10 mg (Turkey) | |
| Amlodis 5 mg (Turkey) | |
| Amlodistad (Denmark, Sweden) | |
| Amlodno (Netherlands) | |
| Amlodowin (Hungary) | |
| Amlody (India) | |
| Tablet; Oral; Amlodipine Succinate 10 mg (Malody) | |
| Tablet; Oral; Amlodipine Succinate 5 mg (Malody) | |
| Amlody Ambroxol 15 mg, terbutalinesulphate 1.25 mg, guaiphenesin50 mg, menthol 2.5 mg/5 mL. SYR / 100ml (Malody) | $ 0.41 |
| AMLODY syr 100ml (Malody) | $ 0.41 |
| AMLOEDGE | |
| AMLOEDGE 5 MG TABLET 1 strip / 10 tablets each (Corona (Wellness)) | $ 0.14 |
| AMLOEDGE tab 5 mg x 10's (Corona (Wellness)) | $ 0.14 |
| Amloedge 5mg Tablet (Corona (Wellness)) | $ 0.01 |
| Amloence (Myanmar) | |
| Amlofine (Kenya) | |
| Amlogal (Belgium, Bosnia & Herzegowina, Serbia) | |
| Amlogal 10mg (Luxembourg) | |
| Amlogard (India) | |
| AMLOGARD Capsule/ Tablet / 10mg / 10 units (Pfizer) | $ 1.38 |
| AMLOGARD Capsule/ Tablet / 5mg / 10 units (Pfizer) | $ 0.93 |
| Amlogard 2.5mg TAB / 10 (Pfizer) | $ 0.49 |
| Amlogard 5mg TAB / 10 (Pfizer) | $ 0.96 |
| Amlogard 10mg TAB / 10 (Pfizer) | $ 1.38 |
| 2.5 mg x 10's (Pfizer) | $ 0.49 |
| 5 mg x 10's (Pfizer) | $ 0.96 |
| 10 mg x 10's (Pfizer) | $ 1.38 |
| AMLOGARD 10 MG TABLET 1 strip / 30 tablets each (Pfizer) | $ 1.79 |
| AMLOGARD 2.5 MG TABLET 1 strip / 30 tablets each (Pfizer) | $ 0.73 |
| AMLOGARD 5 MG TABLET 1 strip / 30 tablets each (Pfizer) | $ 0.88 |
| AMLOGARD tab 2.5 mg x 10's (Pfizer) | $ 0.53 |
| AMLOGARD tab 5 mg x 10's (Pfizer) | $ 1.04 |
| AMLOGARD tab 10 mg x 10's (Pfizer) | $ 1.38 |
| Amlogard 10mg Tablet (Pfizer) | $ 0.15 |
| Amlogard 2.5mg Tablet (Pfizer) | $ 0.02 |
| Amlogard 5mg Tablet (Pfizer) | $ 0.03 |
| AMLOGEN (Bulgaria, India) | |
| AMLOGEN Capsule/ Tablet / 10mg / 10 units (Alkem) | $ 0.31 |
| AMLOGEN Capsule/ Tablet / 5mg / 10 units (Alkem) | $ 0.21 |
| AMLOGEN Capsule/ Tablet / 2.5mg / 10 units (Alkem) | $ 0.11 |
See 4039 substitutes for Amlodipino Aurovitas | |
References
- PubChem. "amlodipine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "amlodipine". http://www.drugbank.ca/drugs/DB00381 (accessed September 17, 2018).
- MeSH. "Antihypertensive Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
