What is Amlodipino Chemopharma?
Amlodipino Chemopharma is used alone or together with other medicines to treat angina (chest pain) and high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Amlodipino Chemopharma is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. As a result, Amlodipino Chemopharma relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.
Amlodipino Chemopharma is available only with your doctor's prescription.
Amlodipino Chemopharma indications
Hypertension: Amlodipino Chemopharma is indicated for the first-line treatment of hypertension and can be used as the sole agent to control blood pressure in the majority of patients. Patients not adequately controlled on a single antihypertensive agent may benefit from the addition of Amlodipino Chemopharma, which has been used in combination with a thiazide diuretic, β-adrenoceptor-blocking agent or an angiotensin-converting enzyme inhibitor.
Amlodipino Chemopharma is also indicated to reduce the risk of fatal coronary heart disease (CHD) and non-fatal myocardial infarction (MI), and to reduce the risk of stroke.
Coronary Artery Disease: Amlodipino Chemopharma is indicated to reduce the risk of coronary revascularization and the need for hospitalization due to angina in patients with coronary artery disease (CAD).
Chronic Stable Angina: Amlodipino Chemopharma is indicated for the first-line treatment of myocardial ischemia, whether due to fixed obstruction (stable angina) and/or vasospasm/vasoconstriction (Prinzmetal’s or variant angina) of coronary vasculature. Amlodipino Chemopharma may be used where the clinical presentation suggests a possible vasospastic/vasoconstrictive component but where vasospasm/vasoconstriction has not been confirmed. Amlodipino Chemopharma may be used alone, as monotherapy, or in combination with other antianginal drugs in patients with angina that is refractory to nitrates and/or adequate doses of beta-blockers.
How should I use Amlodipino Chemopharma?
Use Amlodipino Chemopharma as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Amlodipino Chemopharma. Talk to your pharmacist if you have questions about this information.
- Take Amlodipino Chemopharma by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Taking Amlodipino Chemopharma at the same time each day will help you remember to take it.
- Continue to take Amlodipino Chemopharma even if you feel well. Do not miss any doses.
- If you miss a dose of Amlodipino Chemopharma, take it as soon as possible. If it has been more than 12 hours since you missed your last dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Amlodipino Chemopharma.
Uses of Amlodipino Chemopharma in details
This medication is used along with other treatment for certain blood vessel diseases (e.g., arteriosclerosis obliterans, Raynaud's disease, Buerger's disease, cerebrovascular insufficiency). It works by widening blood vessels to help increase blood flow (improve circulation) to certain parts of the body (e.g., hands/feet, brain). This effect may help to decrease symptoms such as cold hands and feet, numbness, tingling, and decreased memory or judgment.
How to use Amlodipino Chemopharma
This medication is taken by mouth with or without food, usually 3 to 4 times daily or as directed by your doctor. Dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
Tell your doctor if your condition persists or worsens.
Amlodipino Chemopharma description
Each 5-mg and 10-mg tablet contains Amlodipine besilate equivalent to Amlodipino Chemopharma 5 mg and 10 mg, respectively.
Amlodipino Chemopharma also contains the following excipients: Calcium hydrogen phosphate anhydrous, microcrystalline cellulose, magnesium stearate, sodium starch glycollate.
Amlodipino Chemopharma besilate is the besilate salt of Amlodipino Chemopharma, a long-acting calcium-channel blocker. It is 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulphonate. Its empirical formula is C20H25ClN2O5·C6H6O3S and has a molecular weight of 567.1.
Amlodipino Chemopharma besilate is a white crystalline powder and is slightly soluble in water and sparingly soluble in ethanol.
Amlodipino Chemopharma dosage
For both hypertension and angina, the usual initial dose is 5 mg Amlodipino Chemopharma once daily, which may be increased to a maximum dose of 10 mg depending on the individual patient's response.
For patients with coronary artery disease, the recommended dosage range is 5 mg to 10 mg once daily. In clinical studies, the majority of patients required 10 mg once daily.
No dose adjustment of Amlodipino Chemopharma is required upon concomitant administration of thiazide diuretics, beta-blockers, and ACE inhibitors.
Amlodipino Chemopharma ODT: For Amlodipino Chemopharma orodispersible tablets, the patient should place the tablet on the tongue and allow it to dissolve.
Elderly: Normal dosage regimens are recommended. Amlodipino Chemopharma, used at similar doses in the elderly or younger patients, is equally well-tolerated.
Children: Safety and effectiveness of Amlodipino Chemopharma in children have not been established.
Patients with Impaired Hepatic Function: See Precautions.
Patients with Renal Failure: Amlodipino Chemopharma may be used at normal doses in patients with renal failure.
Changes in Amlodipino Chemopharma plasma concentrations are not correlated with the degree of renal impairment. Amlodipino Chemopharma is not dialyzable.
Amlodipino Chemopharma interactions
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What other drugs will affect Amlodipino Chemopharma?
In vitro data in human plasma indicate that Amlodipino Chemopharma has no effect on the protein-binding of drugs tested (digoxin, phenytoin, warfarin and indomethacin).
Special Studies: Effect of Other Agents on Amlodipino Chemopharma:
Cimetidine: Co-administration of Amlodipino Chemopharma with cimetidine did not alter the pharmacokinetics of Amlodipino Chemopharma.
Grapefruit Juice: Co-administration of 240 mL of grapefruit juice with a single oral dose of Amlodipino Chemopharma 10 mg in 20 healthy volunteers had no significant effect on the pharmacokinetics of Amlodipino Chemopharma.
Antacid: Co-administration of antacid with a single dose of Amlodipino Chemopharma had no significant effect on the pharmacokinetics of Amlodipino Chemopharma.
Sildenafil: A single 100-mg dose of sildenafil in subjects with essential hypertension had no effect on the pharmacokinetic parameters of Amlodipino Chemopharma. When Amlodipino Chemopharma and sildenafil were used in combination, each agent independently exerted its own blood pressure-lowering effect.
Effect of Amlodipino Chemopharma on Other Agents: Atorvastatin: Co-administration of multiple 10-mg doses of Amlodipino Chemopharma with 80 mg of atorvastatin resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.
Digoxin: Co-administration of Amlodipino Chemopharma with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers.
Ethanol (alcohol): Single and multiple 10-mg doses of Amlodipino Chemopharma had no significant effect on the pharmacokinetics of ethanol.
Warfarin: Co-administration of Amlodipino Chemopharma with warfarin did not change the warfarin prothrombin response time.
In clinical trials, Amlodipino Chemopharma has been safely administered with thiazide diuretics, β-blockers, ACE inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, NSAIDs, antibiotics and oral hypoglycemic drugs.
Drug/Laboratory Test Interactions: None known.
Amlodipino Chemopharma side effects
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What are the possible side effects of Amlodipino Chemopharma?
The most common adverse effects of Amlodipino Chemopharma besilate, similar to that of other calcium-channel blockers, are associated with its vasodilating effects are often lessened with continued use of the drug. Among them are flushing, headache disorders, dizziness and peripheral edema, the most common of which are edema and flushing which are due to the vasodilating effect of Amlodipino Chemopharma.
Abdominal pain with cramps, fatigue, palpitations, tachycardia and nausea are less frequently experienced with the use of Amlodipino Chemopharma.
Other adverse effects associated with the use of Amlodipino Chemopharma include increased micturition, eye pain and other visual disturbances, mental or mood changes eg, depression, anxiety or nervousness, decreased sexual ability/desire, constipation and fainting.
At the start of the treatment, a paradoxical increase in ischemic chest pain may be experienced. In some patients, cerebral or myocardial ischemia or transient blindness caused by excessive fall in blood pressure occur. Amlodipino Chemopharma, in 1 study was found to induce gingival overgrowth.
Hypersensitivity reactions to Amlodipino Chemopharma may occur leading to rashes, including erythema multiforme, fever and abnormal liver functions eg, cholestasis. Other symptoms of allergic reactions are itching, swelling, severe dizziness and trouble breathing.
Amlodipino Chemopharma contraindications
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What is the most important information I should know about Amlodipino Chemopharma?
Before taking Amlodipino Chemopharma, tell your doctor if you have congestive heart failure or liver disease.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Amlodipino Chemopharma.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Amlodipino Chemopharma is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.
Tell your doctor about all other heart or blood pressure medications you are taking.
Your chest pain may become worse when you first start taking Amlodipino Chemopharma or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.
Active ingredient matches for Amlodipino Chemopharma:
Amlodipine in Chile.
List of Amlodipino Chemopharma substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Amlodipino Zentiva (Spain) | |
| Amlodipinum (Poland) | |
| Amlodipinum 123ratio (Poland) | |
| Amlodipinum Tad (Poland) | |
| Amlodipress 1A Pharma (Hungary) | |
| Amlodis (Tunisia, Turkey) | |
| Amlodis 10 mg (Turkey) | |
| Amlodis 5 mg (Turkey) | |
| Amlodistad (Denmark, Sweden) | |
| Amlodno (Netherlands) | |
| Amlodowin (Hungary) | |
| Amlody (India) | |
| Tablet; Oral; Amlodipine Succinate 10 mg (Malody) | |
| Tablet; Oral; Amlodipine Succinate 5 mg (Malody) | |
| Amlody Ambroxol 15 mg, terbutalinesulphate 1.25 mg, guaiphenesin50 mg, menthol 2.5 mg/5 mL. SYR / 100ml (Malody) | $ 0.41 |
| AMLODY syr 100ml (Malody) | $ 0.41 |
| AMLOEDGE | |
| AMLOEDGE 5 MG TABLET 1 strip / 10 tablets each (Corona (Wellness)) | $ 0.14 |
| AMLOEDGE tab 5 mg x 10's (Corona (Wellness)) | $ 0.14 |
| Amloedge 5mg Tablet (Corona (Wellness)) | $ 0.01 |
| Amloence (Myanmar) | |
| Amlofine (Kenya) | |
| Amlogal (Belgium, Bosnia & Herzegowina, Serbia) | |
| Amlogal 10mg (Luxembourg) | |
| Amlogard (India) | |
| AMLOGARD Capsule/ Tablet / 10mg / 10 units (Pfizer) | $ 1.38 |
| AMLOGARD Capsule/ Tablet / 5mg / 10 units (Pfizer) | $ 0.93 |
| Amlogard 2.5mg TAB / 10 (Pfizer) | $ 0.49 |
| Amlogard 5mg TAB / 10 (Pfizer) | $ 0.96 |
| Amlogard 10mg TAB / 10 (Pfizer) | $ 1.38 |
| 2.5 mg x 10's (Pfizer) | $ 0.49 |
| 5 mg x 10's (Pfizer) | $ 0.96 |
| 10 mg x 10's (Pfizer) | $ 1.38 |
| AMLOGARD 10 MG TABLET 1 strip / 30 tablets each (Pfizer) | $ 1.79 |
| AMLOGARD 2.5 MG TABLET 1 strip / 30 tablets each (Pfizer) | $ 0.73 |
| AMLOGARD 5 MG TABLET 1 strip / 30 tablets each (Pfizer) | $ 0.88 |
| AMLOGARD tab 2.5 mg x 10's (Pfizer) | $ 0.53 |
| AMLOGARD tab 5 mg x 10's (Pfizer) | $ 1.04 |
| AMLOGARD tab 10 mg x 10's (Pfizer) | $ 1.38 |
| Amlogard 10mg Tablet (Pfizer) | $ 0.15 |
| Amlogard 2.5mg Tablet (Pfizer) | $ 0.02 |
| Amlogard 5mg Tablet (Pfizer) | $ 0.03 |
| AMLOGEN (Bulgaria, India) | |
| AMLOGEN Capsule/ Tablet / 10mg / 10 units (Alkem) | $ 0.31 |
| AMLOGEN Capsule/ Tablet / 5mg / 10 units (Alkem) | $ 0.21 |
| AMLOGEN Capsule/ Tablet / 2.5mg / 10 units (Alkem) | $ 0.11 |
See 4039 substitutes for Amlodipino Chemopharma | |
References
- PubChem. "amlodipine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "amlodipine". http://www.drugbank.ca/drugs/DB00381 (accessed September 17, 2018).
- MeSH. "Antihypertensive Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
