What is Amoxy + Clav Potas Com?
Amoxicillin (Amoxy + Clav Potas Com) is an antibiotic in a group of drugs called penicillins. Amoxicillin (Amoxy + Clav Potas Com) fights bacteria in the body.
Clavulanate potassium is a form of Clavulanic Acid (Amoxy + Clav Potas Com), which is similar to penicillin. Clavulanate potassium fights bacteria that is often resistant to penicillins and other antibiotics.
The combination of Amoxicillin (Amoxy + Clav Potas Com) and clavulanate potassium is used to treat many different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.
Amoxicillin (Amoxy + Clav Potas Com) and clavulanate potassium may also be used for purposes not listed in this medication guide.
Amoxy + Clav Potas Com indications
Amoxy + Clav Potas Com-600 is indicated for the treatment of pediatric patients with recurrent or persistent acute otitis media due to S. pneumoniae (penicillin MICs ≤ 2 mcg/mL), H. influenzae (including β-lactamase–producing strains), or M. catarrhalis (including β-lactamase–producing strains) characterized by the following risk factors:
- antibiotic exposure for acute otitis media within the preceding 3 months, and either of the following:
- age ≤ 2 years
- daycare attendance
NOTE: Acute otitis media due to S. pneumoniae alone can be treated with Amoxicillin (Amoxy + Clav Potas Com). Amoxy + Clav Potas Com-600 is not indicated for the treatment of acute otitis media due to S. pneumoniae with penicillin MIC ≥ 4 mcg/mL.
Therapy may be instituted prior to obtaining the results from bacteriological studies when there is reason to believe the infection may involve both S. pneumoniae (penicillin MIC ≤ 2 mcg/mL) and the β-lactamase–producing organisms listed above.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Amoxy + Clav Potas Com-600 and other antibacterial drugs, Amoxy + Clav Potas Com-600 should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Amoxy + Clav Potas Com description
Each film-coated tablet contains Amoxicillin (Amoxy + Clav Potas Com) trihydrate equivalent to Amoxicillin (Amoxy + Clav Potas Com) 500 mg, and potassium clavulanate equivalent to Clavulanic Acid (Amoxy + Clav Potas Com) 125 mg, respectively.
Each vial contains Amoxicillin (Amoxy + Clav Potas Com) sodium equivalent to Amoxicillin (Amoxy + Clav Potas Com) 1000 mg and clavulanate potassium equivalent to Clavulanic Acid (Amoxy + Clav Potas Com) 200 mg, respectively.
Amoxy + Clav Potas Com tablets also contains the following excipients: Microcrystalline cellulose, sodium starch glycolate, anhydrous colloidal silica, povidone (K30), eudragit E 100, isopropyl alcohol, magnesium stearate, white opadryl 03B58965, PEG400, methylene chloride.
Amoxy + Clav Potas Com is an antibacterial combination consisting of the semi-synthetic antibiotic Amoxicillin (Amoxy + Clav Potas Com) and the β-lactamase inhibitor, clavulanate potassium (the potassium salt of Clavulanic Acid (Amoxy + Clav Potas Com)). Amoxicillin (Amoxy + Clav Potas Com) is an analog of ampicillin, derived from the basic penicillin nucleus, 6-aminopenicillanic acid. Its molecular formula is C16H19N305S3H20 and the molecular weight is 419.46. Chemically, Amoxicillin (Amoxy + Clav Potas Com) is (2S, 5R, 6R)-6-[(R)-(-)-2-Amino-2-(p-hydroxyphenyl) acetamido]-3, 3-dimethyl-7-oxo-4-1-azabicyclo[3.2.1] heptane-2-carboxylic acid trihydrate.
Amoxicillin (Amoxy + Clav Potas Com): Clavulanic Acid (Amoxy + Clav Potas Com) is produced by the fermentation of Streptomyces clavuligerus. It is a β-lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of β-lactamases by blocking the active sites of these enzymes. Clavulanic Acid (Amoxy + Clav Potas Com) is particularly active against the clinically important plasmid-mediated β-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins. The clavulanate potassium molecular formula is C8H8KN05 and the molecular weight is 237.25. Chemically, clavulanate potassium is potassium (Z)-(2R, 5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]-heptane-2-carboxylate.
Amoxy + Clav Potas Com dosage
Tablet: Tablets should be taken immediately before a meal.
General Information: For infections caused by Amoxicillin (Amoxy + Clav Potas Com)-sensitive organisms, the dosage is that approved for Amoxicillin (Amoxy + Clav Potas Com) as the Clavulanic Acid (Amoxy + Clav Potas Com) component does not contribute to the therapeutic effect.
Adults: 1 or 2 Amoxy + Clav Potas Com 375 mg tab 8 hourly or 1 Amoxy + Clav Potas Com 625 mg tab 8 hourly for more severe infections and infections of the respiratory tract.
For Amoxicillin (Amoxy + Clav Potas Com)-resistant organisms, the dosage of Amoxy + Clav Potas Com tablets are as follows:
Since both Amoxy + Clav Potas Com 375 mg and 625 mg contain the same amount of Clavulanic Acid (Amoxy + Clav Potas Com) (125 mg, as the potassium salt), 2 Amoxy + Clav Potas Com 375 mg are not equivalent to 1 Amoxy + Clav Potas Com 625 mg. Therefore, 2 Amoxy + Clav Potas Com 375 mg should not be substituted for 1 Amoxy + Clav Potas Com 625 mg for treatment of more severe infections.
Renal Failure: Both Amoxicillin (Amoxy + Clav Potas Com) and Clavulanic Acid (Amoxy + Clav Potas Com) are excreted by the kidneys and the serum t½ of each increases in patients with renal failure. Therefore, the dose may need to be reduced or the interval extended. The following schedule in the dosage is proposed:
Haemodialysis decreases serum concentrations of both Amoxicillin (Amoxy + Clav Potas Com) and Clavulanic Acid (Amoxy + Clav Potas Com) and an additional dose should be administered at the end of dialysis.
Oral Suspension:
Suspensions should be taken immediately before a meal.Reconstitution: For reconstitution to 30 mL, add water till the mark, invert the bottle and shake well until all the powder is dispersed.
Children: 25-50 mg/kg/day of the 4 parts Amoxicillin (Amoxy + Clav Potas Com), 1 part Clavulanic Acid (Amoxy + Clav Potas Com) preparations (which corresponds to a daily dosage of the equivalent of Amoxicillin (Amoxy + Clav Potas Com) 20-40 mg/kg and Clavulanic Acid (Amoxy + Clav Potas Com) 5-10 mg/kg) to be taken in divided doses every 8 hrs at the start of a meal.
Dosage Guide:
To correspond to a dosage of 25-50 mg/kg/day.
To correspond to a dosage of 50 mg/kg/day.
IV/IM: Amoxy + Clav Potas Com may be administered by the IV routes.
Amoxy + Clav Potas Com is administered by IM or slow IV injection in doses of 500 mg every 8 hrs.
Severe Infections: 1 g every 6 hrs by slow IV injection over 3-4 min or by infusion over 30-60 min.
Children ≤10 years: 50-100 mg/kg body weight daily by injection in divided doses.
Amoxy + Clav Potas Com interactions
See also:
What other drugs will affect Amoxy + Clav Potas Com?
Probenecid decreases the renal excretion of Amoxicillin (Amoxy + Clav Potas Com). Concurrent use with Amoxy + Clav Potas Com may result in increased and prolonged blood levels of Amoxicillin (Amoxy + Clav Potas Com).
The concurrent administration of allopurinol and ampicillin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. But it is not known whether this potentiation of ampicillin rash is due to allopurinol or the hyperuricemia present in these patients.
Amoxy + Clav Potas Com should not be co-administrated with disulfiram.
Prolongation of bleeding time and prothrombin time have been reported in some patients receiving Amoxy + Clav Potas Com. Thus, Amoxy + Clav Potas Com should be used with care in patients on anticoagulation therapy.
Amoxy + Clav Potas Com may reduce the effect of oral contraceptives and the caution should be given to patients.
Laboratory Test Interactions: Amoxy + Clav Potas Com results in high urine concentration. High urine concentration of ampicillin may result in false-positive reactions when testing for the presence of glucose in urine using Clinitest, Benedict or Fehling's solution.
Amoxy + Clav Potas Com side effects
See also:
What are the possible side effects of Amoxy + Clav Potas Com?
The most frequently reported adverse effects were diarrhoea, nausea, vomiting, abdominal pain, skin rashes, urticaria and erythema multiforme, vaginitis, abnormal taste, headache, dizziness, tiredness and hot flushes. The incidence and severity of adverse effects, particularly nausea and diarrhoea, increased with the higher recommended dose and can be minimised by administering the agent at the start of a meal. In addition, as these symptoms are especially related to the potassium clavulanate component, where these GI symptoms occur and a higher concentration of Amoxicillin (Amoxy + Clav Potas Com) is required, consideration should be given to administering the additional Amoxicillin (Amoxy + Clav Potas Com) separately.
Hepatitis and cholestatic jaundice have been reported with the combination of Amoxicillin (Amoxy + Clav Potas Com) and Clavulanic Acid (Amoxy + Clav Potas Com); the Clavulanic Acid (Amoxy + Clav Potas Com) component has been implicated. The events associated with Amoxy + Clav Potas Com may be severe and occur predominantly in adult or elderly patients. Signs and symptoms usually occur during or shortly after treatment, but in some cases may not become apparent until several weeks after treatment has ceased. The hepatic events are usually reversible. However, in extremely rare circumstances, death has been reported. These have almost always been cases associated with serious underlying disease or concomitant medication.
A moderate rise in aspartate transaminase and/or alanine transaminase has been noted in patients treated with Amoxy + Clav Potas Com, the significance of these findings is unknown.
The following adverse reactions have been reported for ampicillin class antibiotics and may occur with Amoxy + Clav Potas Com.
Gastrointestinal: Gastritis, stomatitis, glossitis, black hairy tongue, enterocolitis and pseudomembranous colitis. If GI reactions are evident, they may be reduced by taking Amoxy + Clav Potas Com at the start of a meal.
Amoxicillin (Amoxy + Clav Potas Com) causes hypersensitivity reactions similar to those induced by penicillin G and ampicillin, including rashes and fever. The incidence of these reaction is probably no higher than with other penicillins. Sensitivity reactions are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillins and in those with a history of allergy, asthma, hay fever or uticaria. Hypersensitivity reactions include skin rashes, urticaria, erythema multiforme, rare cases of Stevens-Johnson syndrome and less frequently exfoliative dermatitis and toxic epidermal necrolysis have been reported. Whenever such reactions occur, Amoxy + Clav Potas Com should be discontinued. Serious and occasional fatal hypersensitivity (anaphylactic) reactions and angioneurotic oedema can occur with oral penicillin.
Haematopoietic and Lymphatic: Anaemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leucopenia and agranulocytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena. A slight thrombocytosis was noted in patients treated with Amoxy + Clav Potas Com. Prolongation of bleeding time and prothrombin time have also been reported less frequently.
Amoxicillin (Amoxy + Clav Potas Com) alone or in combination with Clavulanic Acid (Amoxy + Clav Potas Com) has been associated with acute hepatic dysfunction. The incidence rate (95% confidence intervals) were 1.7 (1.1-2.7) (Amoxicillin (Amoxy + Clav Potas Com)-Clavulanic Acid (Amoxy + Clav Potas Com)) and 0.3 (0.2-0.5)/10,000 prescriptions (Amoxicillin (Amoxy + Clav Potas Com) alone). Risks were increased in patients receiving >1 course and in older recipients.
Central Nervous System: Reversible hyperactivity, agitation, anxiety, insomnia, confusion, behavioural changes and/or dizziness have also been reported. Depression, seizures or hallucinations.
Amoxy + Clav Potas Com contraindications
Hypersensitivity to the Amoxicillin (Amoxy + Clav Potas Com)/clavulanate potassium to any of the penicillins or to any of the excipients of Amoxy + Clav Potas Com.
History of a severe immediate hypersensitivity reaction (eg, anaphylaxis) to another β-lactam agent (eg, a cephalosporin, carbapenem or monobactam).
History of cholestatic jaundice/hepatic dysfunction due to Amoxy + Clav Potas Com.
Active ingredient matches for Amoxy + Clav Potas Com:
List of Amoxy + Clav Potas Com substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| AMOXY(SYMBIOSIS) | |
| AMOXY PLUS CV 500 MG/125 MG TABLET 1 strip / 6 tablets each (Symbiosis Lab) | $ 1.77 |
| AMOXYCILLIN 250MG+POTASSIUM CLAVULANATE 125MG | |
| AMOXYCILLIN 250MG+POTASSIUM CLAVULANATE 125MG TABLET 1 strip / 6 tablets each (Jan Aushadhi) | $ 0.36 |
| Amoxycillin; Clavulanic Acid | |
| Amoxyclav (Australia, Georgia) | |
| Injectable; Injection; Amoxicillin Sodium 1000 mg; Clavulanic Acid / Clavulanate Potassium 200 mg (Abbott) | |
| Amoxyclav Amoxicillin 1 g, clavulanatepotassium 0.2 g. POWD / 1 (Abbott) | $ 2.16 |
| AMOXYCLAV 1000 MG/200 MG INJECTION 1 vial / 1 injection each (Abbott) | $ 0.68 |
| AMOXYCLAV 500 MG/125 MG TABLET 1 strip / 6 tablets each (Abbott) | $ 1.23 |
| Amoxyclav 1000 mg/200 mg Injection (Abbott) | $ 0.72 |
| Amoxyclav 250mg/125mg Tablet (Abbott) | $ 0.10 |
| Amoxyclav 500 mg/125 mg Tablet (Abbott) | $ 0.21 |
| Amoxyclav 200 (Australia) | |
| Amoxyclav 250 (Australia) | |
| Amoxyclav 50 (Australia) | |
| Amoxyclav 500 (Australia) | |
| Amoxyclav AN (Australia) | |
| Amoxyclav Generichealth (Australia) | |
| AmoxyClav GH (Australia) | |
| AmoxyClav RBX (Australia) | |
| Amoxyplus (Spain) | |
| Amoxytek (India) | |
| Amoxytek Amoxicillin 500 mg, Clavulanicacid 125 mg. TAB (Arunabh) | |
| Amoxytek Amoxicillin 250 mg, Clavulanicacid 125 mg. TAB (Arunabh) | |
| AMOXYTEK tab 10's (Arunabh) | |
| Amphy-CV (India) | |
| Amphy-CV Amoxicillin 500 mg, clavulanicacid 125 mg. CAP / 10 (Profic) | $ 1.45 |
| AMPHY-CV cap 10's (Profic) | $ 1.45 |
| AMPILOX CV | |
| AMPILOX CV 1000 MG/200 MG INJECTION 1 vial / 1 injection each (Biochem Pharmaceutical Industries) | $ 1.54 |
| AMPILOX CV 200 MG/28.5 MG DRY SYRUP 1 bottle / 30 ML dry syrup each (Biochem Pharmaceutical Industries) | $ 0.71 |
| AMPILOX CV 250 MG/125 MG TABLET 1 strip / 10 tablets each (Biochem Pharmaceutical Industries) | $ 1.81 |
| AMPILOX CV 500 MG/125 MG TABLET 1 strip / 10 tablets each (Biochem Pharmaceutical Industries) | $ 1.86 |
| Ampilox CV 200 mg/28.5 mg Dry Syrup (Biochem Pharmaceutical Industries) | $ 0.71 |
| Ampilox CV 250 mg/125 mg Tablet (Biochem Pharmaceutical Industries) | $ 0.18 |
| Ampilox CV 500 mg/125 mg Tablet (Biochem Pharmaceutical Industries) | $ 0.19 |
| AMPILOX CV KID | |
| AMPILOX CV KID 200 MG/28.5 MG TABLET 1 strip / 10 tablets each (Biochem Pharmaceutical Industries) | $ 1.07 |
| Amplamox AC (Brazil) | |
| Amplamox Plus (Portugal) | |
| AMPLIFYER | |
| AMPLIFYER 250MG/125MG TABLET 1 strip / 10 tablets each (Unireach Healthcare Pvt Ltd) | $ 1.63 |
| AMPLIFYER 500MG/125MG TABLET 1 strip / 10 tablets each (Unireach Healthcare Pvt Ltd) | $ 2.05 |
| AMPLIFYER DRY SYRUP 1 bottle / 30 ML dry syrup each (Unireach Healthcare Pvt Ltd) | $ 0.54 |
| Amplifyer 250 mg/125 mg Tablet (Unireach Healthcare Pvt Ltd) | $ 0.16 |
| Amplifyer 500 mg/125 mg Tablet (Unireach Healthcare Pvt Ltd) | $ 0.20 |
| Amplifyer Dry Syrup (Unireach Healthcare Pvt Ltd) | $ 0.54 |
| Ampliron Duo (Mexico) | |
| AMPOXIN CV | |
| AMPOXIN CV 200 MG/28.5 MG SUSPENSION 1 bottle / 30 ML suspension each (Unichem Laboratories Ltd) | $ 0.67 |
See 7042 substitutes for Amoxy + Clav Potas Com | |
References
- DailyMed. "AMOXICILLIN; CLAVULANATE POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "CLAVULANIC ACID". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "amoxicillin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Amoxy + Clav Potas Com are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Amoxy + Clav Potas Com. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yetConsumer reported age
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
