Dosage of Augmentin 2.2g in details
Augmentin 2.2g-600, 600 mg/5 mL, does not contain the same amount of Clavulanic Acid (Augmentin 2.2g) (as the potassium salt) as any of the other suspensions of AUGMENTIN. Augmentin 2.2g-600 contains 42.9 mg of Clavulanic Acid (Augmentin 2.2g) per 5 mL, whereas the 200 mg/5 mL suspension of AUGMENTIN contains 28.5 mg of Clavulanic Acid (Augmentin 2.2g) per 5 mL and the 400 mg/5 mL suspension contains 57 mg of Clavulanic Acid (Augmentin 2.2g) per 5 mL. Therefore, the 200 mg/5 mL and 400 mg/5 mL suspensions of AUGMENTIN should not be substituted for Augmentin 2.2g-600, as they are not interchangeable.
Dosage
Pediatric patients 3 months and older: Based on the Amoxicillin (Augmentin 2.2g) component (600 mg/5 mL), the recommended dose of Augmentin 2.2g-600 is 90 mg/kg/day divided every 12 hours, administered for 10 days.
| Body Weight (kg) | Volume of Augmentin 2.2g-600 providing 90 mg/kg/day |
| 8 | 3.0 mL twice daily |
| 12 | 4.5 mL twice daily |
| 16 | 6.0 mL twice daily |
| 20 | 7.5 mL twice daily |
| 24 | 9.0 mL twice daily |
| 28 | 10.5 mL twice daily |
| 32 | 12.0 mL twice daily |
| 36 | 13.5 mL twice daily |
Pediatric patients weighing 40 kg and more: Experience with Augmentin 2.2g-600 (600 mg/5 mL formulation) in this group is not available.
Adults: Experience with Augmentin 2.2g-600 (600 mg/5 mL formulation) in adults is not available and adults who have difficulty swallowing should not be given Augmentin 2.2g-600 (600 mg/5 mL) in place of the 500-mg or 875-mg tablet of AUGMENTIN.
Hepatically impaired patients should be dosed with caution and hepatic function monitored at regular intervals.
Directions for Mixing
Oral Suspension
Prepare a suspension at time of dispensing as follows: Tap bottle until all the powder flows freely. Add approximately 2/3 of the total amount of water for reconstitution and shake vigorously to suspend powder. Add remainder of the water and again shake vigorously.
Augmentin 2.2g-600 (600 mg/5 mL Suspension)
| Bottle Size | Amount of Water Required for Reconstitution |
| 75 mL | 70 mL |
| 125 mL | 110 mL |
| 200 mL | 180 mL |
Each teaspoonful (5 mL) will contain 600 mg Amoxicillin (Augmentin 2.2g) as the trihydrate and 42.9 mg of Clavulanic Acid (Augmentin 2.2g) as the potassium salt.
NOTE: SHAKE ORAL SUSPENSION WELL BEFORE USING.
Information for the Pharmacist: For patients who wish to alter the taste of Augmentin 2.2g-600, immediately after reconstitution 1 drop of FLAVORx™ (apple, banana cream, bubble gum, cherry, or watermelon flavor) may be added for every 5 mL of Augmentin 2.2g-600. The resulting suspension is stable for 10 days under refrigeration. Other than the 5 flavors listed above, GlaxoSmithKline has not evaluated the stability of Augmentin 2.2g-600 when mixed with other flavors distributed by FLAVORx.
Administration: To minimize the potential for gastrointestinal intolerance, Augmentin 2.2g-600 should be taken at the start of a meal. Absorption of clavulanate potassium may be enhanced when Augmentin 2.2g-600 is administered at the start of a meal.
How supplied
Augmentin 2.2g-600, 600 mg/5 mL, for
Oral Suspension:
Each 5 mL of reconstituted strawberry cream-flavored suspension contains 600 mg Amoxicillin (Augmentin 2.2g) and 42.9 mg Clavulanic Acid (Augmentin 2.2g) as the potassium salt.NDC 43598-003-69
What other drugs will affect Augmentin 2.2g?
Tell your doctor about all other medications you use, especially:
- allopurinol (Zyloprim);
- probenecid (Benemid);
- a blood thinner such as warfarin (Coumadin, Jantoven); or
- another antibiotic (for the same or for a different infection).
This list is not complete and other drugs may interact with Amoxicillin (Augmentin 2.2g) and clavulanate potassium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Augmentin 2.2g interactions
Administration of probenecid prior to dosing results in marked increase in the mean serum concentrations of Amoxicillin (Augmentin 2.2g). Probenecid decreases the renal tubular secretion of Amoxicillin (Augmentin 2.2g), but does not affect Clavulanic Acid (Augmentin 2.2g) excretion. Concurrent use with Augmentin 2.2g may result in increased and prolonged blood levels of Amoxicillin (Augmentin 2.2g) but not of Clavulanic Acid (Augmentin 2.2g).
When Amoxicillin (Augmentin 2.2g) and warfarin are taken concomitantly, the INR can be altered.
Interaction of Augmentin 2.2g with coumarin or indandione-derivative anticoagulants, heparin, NSAIDs especially aspirin, other platelet aggregation inhibitors or thrombolytic agents may be clinically significant.
Augmentin 2.2g may decrease the efficacy of oestrogen-containing oral contraceptives. Patients should be warned accordingly. The simultaneous use of Amoxicillin (Augmentin 2.2g) and an oral contraceptive might be expected to cause breakthrough bleeding or pregnancy on rare occasions because of reduced absorption owing to diarrhea, on the basis of experience with ampicillin.
The concurrent administration of allopurinol and ampicillin substantially increases the incidence of rashes in patients receiving both agents as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricaemia present in these patients. There are no data on Amoxicillin (Augmentin 2.2g)/clavulanate combination and allopurinol administered concurrently.
No information is available about the concurrent use of Augmentin 2.2g and alcohol. However, the ingestion of alcohol whilst being treated with some other β-lactam antibiotics has precipitated a disulfiram (Antabuse)-like reaction in some patients. Therefore, the ingestion of alcohol should be avoided during and for several days after treatment with Augmentin 2.2g.
Following administration of ampicillin to pregnant women, a transient decrease in plasma concentration of total conjugate oestriol, oestrio-glucuronide, conjugated oestrone and oestradiol has been noted. This effect may also occur with Amoxicillin (Augmentin 2.2g) and therefore, Augmentin 2.2g.
The use of this antibiotic may lead to the selection of resistant strains of organisms and sensitivity testing should, therefore, be carried out whenever possible, to demonstrate the appropriateness of therapy.
References
- DailyMed. "AMOXICILLIN; CLAVULANATE POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "9EM05410Q9: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
