What happens if I overdose Augmentin 250 mg/125 mg?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose can cause nausea, vomiting, stomach pain, diarrhea, skin rash, drowsiness, and hyperactivity.
Overdose of Augmentin 250 mg/125 mg in details
Following overdosage, patients have experienced primarily gastrointestinal symptoms including stomach and abdominal pain, vomiting, and diarrhea. Rash, hyperactivity, or drowsiness have also been observed in a small number of patients.
In the case of overdosage, discontinue Augmentin 250 mg/125 mg-600, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison control center suggested that overdosages of less than 250 mg/kg of Amoxicillin (Augmentin 250 mg/125 mg) are not associated with significant clinical symptoms and do not require gastric emptying.
Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Amoxicillin (Augmentin 250 mg/125 mg).
Crystalluria, in some cases leading to renal failure, has also been reported after Amoxicillin (Augmentin 250 mg/125 mg) overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Amoxicillin (Augmentin 250 mg/125 mg) crystalluria.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of both Amoxicillin (Augmentin 250 mg/125 mg) and clavulanate. Both Amoxicillin (Augmentin 250 mg/125 mg) and clavulanate are removed from the circulation by hemodialysis.
What should I avoid while taking Augmentin 250 mg/125 mg?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, stop taking this medication and call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Augmentin 250 mg/125 mg warnings
During penicillin therapy serious hypersensitivity (anaphylactic) reactions may occur. These reactions are more likely to appear in persons with a history of hypersensitivity to penicillin or multiple allergens. Prior to the initiation of Augmentin 250 mg/125 mg® therapy, careful inquiry should be made concerning previous hypersensitivity reactions due to penicillin, cephalospon, and other allergens, if allergic reactions occur during therapy, treatment should be discontinued immediately. In serious anaphylactic reactions administration of adrenalin, oxygen, intravenous steroids and intubation may be necessary.
Augmentin 250 mg/125 mg® should be used carefully in patients with renal or hepatic dysfunction, During prolonged therapy be assessed periodically.
Pregnancy : Although animal experients did not demonstrate any teratogenic potential for Augmentin 250 mg/125 mg, controlled studies in humans have not been carried out. Augmentin 250 mg/125 mg® shouls be used in pregnancy only if it is clearly needed.
Pregnancy category is B
Lactation: Antibiotics of ampicillin class diffuse into mother milk. Augmentin 250 mg/125 mg® should be used carefully in nursing mothers.
What should I discuss with my healthcare provider before taking Augmentin 250 mg/125 mg?
Do not use this medication if you are allergic to Amoxicillin (Augmentin 250 mg/125 mg) or clavulanate potassium, or if you have ever had liver problems caused by this medication.
Do not use if you are allergic to any other penicillin antibiotic, such as Amoxicillin (Augmentin 250 mg/125 mg) (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen)), and others.
To make sure you can safely take this medicine, tell your doctor if you have any of these other conditions:
- liver disease (or a history of hepatitis or jaundice);
- kidney disease;
- mononucleosis; or
- if you are allergic to a cephalosporin antibiotic, such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Amoxicillin (Augmentin 250 mg/125 mg) and clavulanate potassium can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Amoxicillin (Augmentin 250 mg/125 mg) and clavulanate potassium.
Amoxicillin (Augmentin 250 mg/125 mg) and clavulanate potassium can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
The liquid and chewable tablet forms of this medication may contain phenylalanine. Talk to your doctor before using these forms of Amoxicillin (Augmentin 250 mg/125 mg) and clavulanate potassium if you have phenylketonuria (PKU).
Augmentin 250 mg/125 mg precautions
Carefully administer to the following patients: Patients with severe hepatic dysfunction; moderate or severe renal dysfunction (dose interval should be adjusted for the patients because blood concentration of Augmentin 250 mg/125 mg can be prolonged.); previous history of hypersensitivity to penicillins or cephems; who or whose family have a tendency to show allergic symptoms eg, bronchial asthma, rashes, urticaria; malnutritioned orally or who are parenterally nutritioned, the elderly patients, and patients with bad systemic condition (vitamin K deficiency may occur).
General: Severe and occasionally fatal hypersensitivity (anaphylactic) reactions and vasculoneural edema may occur in patients treated with penicillin. Such reactions may easily occur in patients who have the previous sensitivity to multiple allergen or the previous penicillin hypersensitivity. Also these reactions may occur in both oral and parenteral therapy, but more frequently in parenteral therapy.
The long-term treatment with Augmentin 250 mg/125 mg may result in overgrowth of nonsusceptible organisms, thus careful observation is required for >14 days treatment.
Changes in liver function test have been observed in some patients receiving Augmentin 250 mg/125 mg. The clinical significance of these changes is uncertain, but Augmentin 250 mg/125 mg should be used with caution in patients with evidence of hepatic failure. Serious and usually reversible cholestatic jaundice have been reported rarely. Signs and symptoms may not occur in appearance until 6 weeks after treatment has ended.
In patients with moderate and severe renal dysfunction, dose of Augmentin 250 mg/125 mg should be adjusted following Dosage & Administration.
Erythematous rashes have been associated with glandular fever in patients receiving Amoxicillin (Augmentin 250 mg/125 mg), thus use of Augmentin 250 mg/125 mg should be avoided in case that glandular fever is worried.
Use in pregnancy & lactation: Animal studies have shown no teratogenic effects; however, safe use of Augmentin 250 mg/125 mg during pregnancy has not been definitely established. Thus, Augmentin 250 mg/125 mg should be used during pregnancy only when the potential benefits justify the possible risks to the fetus. especially Augmentin 250 mg/125 mg should not be administered during the 1st trimester of pregnancy.
During lactation, trace quantities of penicillin can be excreted in breast milk.
What happens if I miss a dose of Augmentin 250 mg/125 mg?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DailyMed. "AMOXICILLIN; CLAVULANATE POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "amoxicillin". http://www.drugbank.ca/drugs/DB01060 (accessed September 17, 2018).
- DrugBank. "CLAVULANIC ACID". http://www.drugbank.ca/drugs/DB00766 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
