Actions of Avil in details
Description: Avil is an alkylamine derivative with histamine H1-receptor antagonist effects. It also has anticholinergic and moderate sedative effects.
Onset: 15-20 min (oral).
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract. Peak plasma concentrations in 1-2.5 hr.
Metabolism: Metabolised to N-desmethylpheniramine and N-didesmethylpheniramine.
Excretion: Via urine (as unchanged drug and metabolites). Terminal half-life: 8-17 hr (IV Avil); 16-19 hr (oral).
Avil administration
Should be taken with food. Take after meals.
Avil pharmacology
Avil is an antihistamine used to treat allergic conditions such as hay fever or urticaria. It is generally sold in combination with other medications, rather than as a stand-alone drug. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting the binding of histamine, antihistamines decrease the normal histamine response from cells, consequently decreasing allergic symptoms.
References
- NCIt. "Phenylephrine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Phenylephrine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
- EPA DSStox. "Pheniramine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Avil are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Avil. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology