Consists of Amoxicillin trihydrate, clavulanate K
What are the possible side effects of Amoxicillin trihydrate (Bifoxit)?
Get emergency medical help if you have any of these signs of an allergic reaction to Amoxicillin trihydrate (Bifoxit): hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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diarrhea that is watery or bloody;
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fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
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swollen glands, rash or itching, joint pain, or general ill feeling;
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pale or yellowed skin, yellowing of the eyes, dark colored urine, fever, confusion or weakness;
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severe tingling, numbness, pain, muscle weakness;
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easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or
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severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Amoxicillin trihydrate (Bifoxit) side effects may include:
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stomach pain, nausea, vomiting, diarrhea;
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vaginal itching or discharge;
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headache; or
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swollen, black, or "hairy" tongue.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Side effects of Amoxicillin trihydrate (Bifoxit) in details
Allergic reactions: urticaria, erythema, edema Quincke, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, in rare cases - anaphylactic shock.
Side effects associated with chemotherapy effect: possible development of super-infection (particularly in patients with chronic diseases or low resistance of the organism).
With prolonged use at high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, seizures.
Mostly when Amoxicillin trihydrate (Bifoxit) used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, a violation of hematopoiesis.
Mostly when Amoxicillin trihydrate (Bifoxit) used in combination with clavulanic acid: cholestatic jaundice, hepatitis, rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.
What is the most important information I should know about Amoxicillin trihydrate (Bifoxit)?
- Amoxicillin trihydrate (Bifoxit) may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Amoxicillin trihydrate (Bifoxit) with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Amoxicillin trihydrate (Bifoxit) only works against bacteria; it does not treat viral infections (eg, the common cold).
- Be sure to use Amoxicillin trihydrate (Bifoxit) for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Long-term or repeated use of Amoxicillin trihydrate (Bifoxit) may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- Do not receive a live vaccine (eg, oral typhoid vaccine) while you are taking Amoxicillin trihydrate (Bifoxit). Talk with your doctor before you receive any vaccine.
- Hormonal birth control (eg, birth control pills) may not work as well while you are using Amoxicillin trihydrate (Bifoxit). To prevent pregnancy, use an extra form of birth control (eg, condoms).
- Brown, yellow, or gray tooth discoloration has occurred rarely in some patients taking Amoxicillin trihydrate (Bifoxit). It occurred most often in children. The discoloration was reduced or removed by brushing or dental cleaning in most cases. Contact your doctor if you experience this effect.
- Diabetes patients - Amoxicillin trihydrate (Bifoxit) may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
- Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed if you use Amoxicillin trihydrate (Bifoxit) for a long period of time. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Caution is advised when using Amoxicillin trihydrate (Bifoxit) in CHILDREN younger than 3 months old; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Amoxicillin trihydrate (Bifoxit) while you are pregnant. Amoxicillin trihydrate (Bifoxit) is found in breast milk. If you are or will be breast-feeding while you use Amoxicillin trihydrate (Bifoxit), check with your doctor. Discuss any possible risks to your baby.
Amoxicillin trihydrate (Bifoxit) contraindications
Infectious mononucleosis, lymphatic leukemia, severe gastrointestinal infections, accompanied by diarrhea or vomiting, respiratory viral infection, allergic diathesis, bronchial asthma, hay fever, sensitivity to penicillin and / or cephalosporins.
For use in combination with metronidazole: diseases of the nervous system; hemodyscrasia, lymphocytic leukemia, an infectious mononucleosis; Hypersensitivity to nitroimidazole derivatives.
For use in combination with clavulanic acid: a history of instructions for liver problems and jaundice, associated with the reception of amoxicillin in combination with clavulanic acid.
References
- DailyMed. "AMOXICILLIN; CLAVULANATE POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "Amoxicillin: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
- HSDB. "AMOXICILLIN". https://toxnet.nlm.nih.gov/cgi-bin/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Bifoxit are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Bifoxit. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported side effects
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Information checked by Dr. Sachin Kumar, MD Pharmacology