Biotin/boron/calcium/calcium d-pantothenate/chloride/chromium/copper/folic acid/iodine/iron/magnesium/manganese/niacinamide/nickel/phosphorus/potassium/selenium/silicon/tin/vanadium/vitamin A/vitamin B1/vitamin B12/vitamin B2/vitamin B6/vitamin C/vitamin D/vitamin E/zinc Side effects

Major: (These usually occur only with an overdose of calcium.)

Calcium contraindications

Calcium chloride is contraindicated for cardiac resuscitation in the presence of ventricular fibrillation or in patients with the risk of existing digitalis toxicity.

Side effects of Chromium in details

None known.

Chromium contraindications

Direct IM or IV injection.

What are the possible side effects of Copper?

Copper can cause serious side effects, including:

• ectopic pregnancy and intrauterine pregnancy risks: There are risks if you become pregnant while using Copper.
• life-threatening infection: Life-threatening infection can occur within the first few days after Copper is placed. Call your healthcare provider immediately if you develop severe pain or fever shortly after Copper is placed.
• pelvic inflammatory disease (PID) or endometritis: Some IUS users get a serious pelvic infection called pelvic inflammatory disease (PID) or endometritis. PID and endometritis are usually sexually transmitted. You have a higher chance of getting PID and endometritis if you or your partner has sex with other partners. PID and endometritis can cause serious problems such as infertility, ectopic pregnancy, and pelvic pain that does not go away. PID and endometritis are usually treated with antibiotics. More serious cases of PID or endometritis may require surgery. A hysterectomy (removal of the uterus) is sometimes needed. In rare cases, infections that start as PID can even cause death.

  Tell your healthcare provider right away if you have any of these signs of PID or endometritis: low abdominal (stomach area) or pelvic pain, pelvic tenderness, painful sex, unusual or bad smelling vaginal discharge, chills, long-lasting or heavy bleeding, fever, genital lesions or sores.

• embedment: Copper may become attached to (embedded) the wall of the uterus. This may make it hard to remove Copper. Surgery may sometimes be needed to remove Copper.
• perforation: Copper may go through the wall of the uterus. This is called perforation. If this occurs, Copper may no longer prevent pregnancy. If perforation occurs, Copper may move outside the uterus and cause internal scarring, infection, damage to other organs, pain, or infertility and you may need surgery to have Copper removed. Excessive pain or vaginal bleeding during placement of Copper, pain or bleeding that gets worse after placement, or not being able to feel the threads may happen with perforation. You are not protected from pregnancy if Copper moves outside the wall of the uterus. The risk of perforation is increased in breastfeeding women.
• expulsion: Copper may partially or completely fall out of the uterus by itself. This is called expulsion. Expulsion occurs in about 2 out of 100 women. Excessive pain, vaginal bleeding during placement of Copper, pain that gets worse, bleeding after placement, or not being able to feel the threads may happen with expulsion. You are not protected from pregnancy if Copper is expelled.
• changes in bleeding: You may have heavier and longer periods with spotting in between. Sometimes the bleeding is heavier than usual at first. Call your healthcare provider if the bleeding remains heavier or longer and spotting continues.
• reactions after placement or removal: Some women have had reactions such as dizziness (syncope), slowed heart rate (bradycardia), or seizures, immediately after Copper was placed or removed. This happened especially in women who have had these conditions before.

Common side effects of Copper include:

• anemia (low red blood cell count)
• backache
• painful periods
• pain during sex
• expulsion (complete or partial)
• vaginal discharge
• prolonged periods
• spotting
• pain and cramping
• vaginal irritation

This is not a complete list of possible side effects with Copper. For more information, ask your healthcare provider. Tell your healthcare provider about any side effect that bothers you or does not go away.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800­ FDA-1088.

See also:

Copper side effects (in more detail)

Side effects of Copper in details

Adverse Reactions

Generally well tolerated; excessive copper levels may result in the following adverse effect.

Hepatic: Hepatic insufficiency (including hepatic necrosis)

Copper contraindications

Copper® should not be placed when one or more of the following conditions exist:

1.

Pregnancy or suspicion of pregnancy

2.

Abnormalities of the uterus resulting in distortion of the uterine cavity

3.

Acute pelvic inflammatory disease, or current behavior suggesting a high risk for pelvic inflammatory disease

4.

Postpartum endometritis or postabortal endometritis in the past 3 months

5.

Known or suspected uterine or cervical malignancy

6.

Genital bleeding of unknown etiology

7.

Mucopurulent cervicitis

8.

Wilson’s disease

9.

Allergy to any component of Copper®

10.

A previously placed IUD that has not been removed

What are the possible side effects of Folic acid?

Get emergency medical help if you have any of these signs of an allergic reaction to folic acid: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely, but may include:

• nausea, loss of appetite;

• bloating, gas;

• bitter or unpleasant taste in your mouth;

• sleep problems;

• depression; or

• feeling excited or irritable.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Folic acid in details

Allergic sensitization has been reported following both oral and parenteral administration of Folic Acid.

Folic Acid is relatively nontoxic in man. Rare instances of allergic responses to Folic Acid preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic Acid daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic Acid therapy.

In an uncontrolled study, orally administered Folic Acid was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic Acid daily.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.

What is the most important information I should know about Folic acid?

You should not use this medication if you have ever had an allergic reaction to folic acid.

Before you take folic acid, tell your doctor if you have kidney disease (or if you are on dialysis), an infection, if you are an alcoholic, or if you have any type of anemia that has not been diagnosed by a doctor and confirmed with laboratory testing.

Talk to your doctor about taking folic acid during pregnancy or while breast-feeding.

Folic acid is sometimes used in combination with other medications to treat pernicious anemia. However, folic acid will not treat Vitamin B12 deficiency and will not prevent possible damage to the spinal cord. Take all of your medications as directed.

Folic acid contraindications

Because it may mask the hematologic abnormalities while neurological damage progresses, folic acid should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The folic acid content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.

What are the possible side effects of Iodine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• swelling, pain, warmth, redness, oozing, or other signs of infection;

• blistering or crusting; or

• severe irritation, itching, or burning.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Iodine side effects (more detail)

Side effects of Iodine in details

Iodine and iodides, whether applied topically or given systemically, can give rise to hypersensitivity reactions which may include urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy, and eosinophilia.

Inhalation of iodine vapour is very irritating to mucous membranes.

Iodine and iodides have variable effects on the thyroid and can produce goitre and hypothyroidism as well as hyperthyroidism (the Iod-Basedow or Jod-Basedow phenomenon). Goitre and hypothyroidism have also occurred in infants born to mothers who had taken iodides during pregnancy.

Prolonged use may lead to a range of adverse effects, often called ’iodism’, some of which may again be due to hypersensitivity. Adverse effects include metallic taste, increased salivation, burning or painful mouth; there may be acute rhinitis, coryza-like symptoms, and swelling and inflammation of the throat. Eyes may be irritated and swollen and there may be increased lachrymation. Pulmonary oedema, dyspnoea, and bronchitis may develop. Skin reactions include acneform or, more rarely, severe eruptions (iododerma). Other reported effects include depression, insomnia, impotence, headache, and gastrointestinal disturbances, notably nausea, vomiting, and diarrhoea.

Iodine contraindications

Allergy to iodine,

- Class III patients with Okuda

- Extrahepatic metastases,

- Respiratory or renal insufficiencies severe

- Cons-indications for hepatic arteriography,

- Leukopenia below 1500/mm3 or thrombocytopenia less 50000/mm3,

- Pregnant woman: Iodine should not be administered to pregnant women. In women of childbearing age, suspicion of pregnancy must be excluded before the administration of Iodine. Contraception must be instituted and prosecuted in the administration at least a year.

- Breastfeeding: Breastfeeding should be stopped.

What are the possible side effects of Iron?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; darkened or green stools; diarrhea; loss of appetite; nausea; stomach cramps, pain, or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or tarry stools; blood or streaks of blood in the stool; fever; severe or persistent nausea, stomach pain, or vomiting; vomit that looks like blood or coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side effects of Iron in details

Applies to carbonyl iron: suspension

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; darkened or green stools; diarrhea; loss of appetite; nausea; stomach cramps, pain, or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking carbonyl iron (the active ingredient contained in Iron)

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or tarry stools; blood or streaks of blood in the stool; fever; severe or persistent nausea, stomach pain, or vomiting; vomit that looks like blood or coffee grounds.

What is the most important information I should know about Iron?

• Do NOT take more than the recommended dose without checking with your doctor.
• Do not take large doses of vitamins (megadoses or megavitamin therapy) while you use Iron unless otherwise instructed by your doctor.
• Iron has iron in it. Before you start any new medicine, check the label to see if it has iron in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Iron may cause darkened or green stools. This is normal and not a cause for concern.
• Some of these products contain sulfites, which can cause allergic reactions in certain individuals (eg, asthma patients). If you have previously had allergic reactions to sulfites, contact your pharmacist to determine if the product you are taking contains sulfites.
• Some of these products contain tartrazine dye (FD&C Yellow No. 5). This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.
• Iron may interfere with certain lab tests, including tests used to check for blood in the stool. Be sure your doctor and lab personnel know you are taking Iron.
• Lab tests, including hematocrit, hemoglobin levels, and blood iron levels, may be performed while you use Iron. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Iron while you are pregnant. Iron is found in breast milk. If you are or will be breast-feeding while you use Iron, check with your doctor. Discuss any possible risks to your baby.

Iron contraindications

All cases of iron overload and disturbances in utilization of iron.

Film-Coated Tablet: Allergy to iron (III)-hydroxide polymaltose complex or any of the other ingredients of Iron.

An iron overload in the body.

Disturbed use of iron by the body.

Reduced number of red blood cells (anaemia), not caused by iron deficiency, such as due to increased red blood cell breakdown, vitamin B₁₂ deficiency.

What are the possible side effects of Magnesium?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using magnesium gluconate and call your doctor at once if you have any of these serious side effects:

• nausea or vomiting;

• fast or slow heart rate;

• feeling light-headed, fainting; or

• warmth, tingling, or redness under your skin.

Continue taking magnesium gluconate and talk to your doctor if you have any of these less serious side effects:

• diarrhea;

• bloating, gas; or

• upset stomach.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Side effects of Magnesium in details

The adverse effects of parenterally administered Magnesium usually are the result of Magnesium intoxication. These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis. Hypocalcemia with signs of tetany secondary to Magnesium sulfate therapy for eclampsia has been reported.

What is the most important information I should know about Magnesium?

• Lab tests, including magnesium levels, may be performed while you use magnesium. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Magnesium should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using magnesium while you are pregnant. It is not known if magnesium is found in breast milk. If you are or will be breast-feeding, check with your doctor. Discuss any possible risks to your baby.

Magnesium contraindications

Do NOT use Magnesium Carbonate/Magnesium Carbonate if:

you are allergic to any ingredient in Magnesium Carbonate/Magnesium Carbonate

you have an increased Magnesium level in your blood

Contact your doctor or health care provider right away if any of these apply to you.

What are the possible side effects of Manganese?

No side effects or toxic effects have been reported for manganese. However, check with your health care professional if you notice any unusual effects while you are taking it.

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Side effects of Manganese in details

None known.

Manganese contraindications

There are no contraindications listed within the manufacturer's US labeling.

What are the possible side effects of Niacinamide?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Flushing. Taking aspirin 30 minutes before taking Niacinamide (niacinamide extended-release tablets) may help. If you wake up at night with flushing, get up slowly if you feel like passing out or you are dizzy.
• Itching.
• Loose stools (diarrhea).
• Upset stomach or throwing up.
• Cough.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Side effects of Niacinamide in details

Applies to niacinamide: tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; itching; nausea; stomach upset; temporary feeling of warmth or flushing of the skin.

Seek medical attention right away if any of these SEVERE side effects occur while taking niacinamide:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; changes in vision; dark urine; decreased urination; fast or irregular heartbeat; loss of appetite; muscle pain or weakness; numbness or persistent tingling of the skin; persistent nausea, vomiting, or general "unwell" feeling; severe or prolonged flushing of the skin; stomach pain; swelling of the hands, legs, or feet; vomit that looks like coffee grounds; yellowing of the skin or eyes.

What is the most important information I should know about Niacinamide?

• Niacinamide is for external use only. Avoid getting Niacinamide in your eyes. If you get Niacinamide in your eyes, rinse thoroughly with cool tap water.
• Follow up with your doctor after 8 to 12 weeks to monitor your progress.
• Do not use any other medicines or special cleansers on your skin unless your doctor instructs you otherwise. Makeup and other acne medicines may be applied over Niacinamide as directed by your doctor.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Niacinamide while you are pregnant. It is not known if Niacinamide is found in breast milk after topical use. If you are or will be breast-feeding while you use Niacinamide, check with your doctor. Discuss any possible risks to your baby.

What are the possible side effects of Potassium?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using potassium citrate and call your doctor at once if you have any of these serious side effects:

• confusion, anxiety, feeling like you might pass out;

• uneven heartbeat;

• extreme thirst, increased urination;

• leg discomfort;

• muscle weakness or limp feeling;

• numbness or tingly feeling in your hands or feet, or around your mouth;

• severe stomach pain, ongoing diarrhea or vomiting;

• black, bloody, or tarry stools; or

• coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

• mild nausea or upset stomach;

• mild or occasional diarrhea; or

• appearance of a potassium citrate tablet in your stool.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Potassium in details

Applies to potassium citrate: oral patch extended release, oral solution, oral tablet, oral tablet extended release

As well as its needed effects, potassium citrate may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking potassium citrate, check with your doctor immediately:

Incidence not known:

• Abdominal or stomach discomfort
• diarrhea
• nausea
• vomiting

If any of the following symptoms of overdose occur while taking potassium citrate, get emergency help immediately:

Symptoms of overdose:

• Abdominal or stomach pain
• confusion
• difficult breathing
• irregular heartbeat
• nervousness
• numbness or tingling in the hands, feet, or lips
• shortness of breath
• weakness or heaviness of the legs

What is the most important information I should know about Potassium?

You should not use potassium citrate if you have kidney failure, a urinary tract infection, uncontrolled diabetes, a peptic ulcer in your stomach, Addison's disease, severe burns or other tissue injury, if you are dehydrated, if you take certain diuretics (water pills), or if you have high levels of potassium in your blood (hyperkalemia).

You should not take potassium citrate tablets if you have problems with your esophagus, stomach, or intestines that make it difficult for you to swallow or digest pills.

Do not crush, chew, break, or suck on an extended-release tablet. Swallow the pill whole. Breaking or crushing the pill may cause too much of the drug to be released at one time. Sucking on a potassium tablet can irritate your mouth or throat. Avoid lying down for at least 30 minutes after you take this medication. Take potassium citrate with a meal or bedtime snack, or within 30 minutes after a meal.

To be sure this medication is helping your condition, your blood may need to be tested often. Your heart rate may also be checked using an electrocardiograph or ECG (sometimes called an EKG) to measure electrical activity of the heart. This test will help your doctor determine how long to treat you with potassium. Do not miss any scheduled appointments.

Serious side effects of potassium citrate include uneven heartbeat, muscle weakness or limp feeling, severe stomach pain, and numbness or tingling in your hands, feet, or mouth.

Do not stop taking potassium citrate without first talking to your doctor. If you stop taking potassium suddenly, your condition may become worse.

Potassium contraindications

Potassium supplements are contraindicated in patients with hyperkalemia since a further increase in serum potassium concentration in such patients can produce cardiac arrest. Hyperkalemia may complicate any of the following conditions: chronic renal failure, systemic acidosis, such as diabetic acidosis, acute dehydration, extensive tissue breakdown as in severe burns, adrenal insufficiency, or the administration of a potassium-sparing diuretic (eg, spironolactone, triamterene, amiloride).

Controlled-release formulations of Potassium Chloride have produced esophageal ulceration in certain cardiac patients with esophageal compression due to enlarged left atrium. Potassium supplementation, when indicated in such patients, should be given as a liquid preparation or as an aqueous (water) suspension of Potassium Chloride.

All solid oral dosage forms of Potassium Chloride are contraindicated in any patient in whom there is structural, pathological (eg, diabetic gastroparesis), or pharmacologic (use of anticholinergic agents or other agents with anticholinergic properties at sufficient doses to exert anticholinergic effects) cause for arrest or delay in tablet passage through the gastrointestinal tract.

What are the possible side effects of Selenium?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Long term use of high selenium doses can lead to dangerous side effects. Stop taking selenium and call your doctor at once if you have:

• nausea, vomiting;

• lack of energy, feeling irritable or very tired

• hair loss, mild rash, brittle or painful fingernails, or white streaks on the nails;

• tremors, feeling light-headed;

• muscle tenderness;

• flushing (warmth, redness, or tingly feeling);

• metallic taste, bad breath, strong body odor; or

• easy bruising or bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Selenium in details

Applies to selenium sulfide topical: topical cream, topical foam, topical lotion, topical shampoo, topical suspension

As well as its needed effects, selenium sulfide topical may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking selenium sulfide topical, check with your doctor or nurse as soon as possible:

Less common or rare:

• Skin irritation

Minor Side Effects

Some selenium sulfide topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

• Unusual dryness or oiliness of hair or scalp

• Increase in normal hair loss

What is the most important information I should know about Selenium?

• Selenium is for external use only. Do not get Selenium in your eyes, nose, mouth, or in the genital area. If you get it in any of these areas, rinse right away with cool water.
• If your symptoms do not get better or if they get worse, check with your doctor.
• Do not use more often or for longer than prescribed without checking with your doctor. If you use topical products too often, some conditions may become worse.
• Do not use Selenium for another skin condition at a later time.
• Do not use Selenium on broken, blistered, or inflamed skin.
• Selenium may cause harm if it is swallowed. If you may have taken it by mouth, contact your or emergency room right away.
• Selenium should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Selenium while you are pregnant. It is not known if Selenium is found in breast milk after topical use. If you are or will be breast-feeding while you use Selenium, check with your doctor. Discuss any possible risks to your baby.

Selenium contraindications

Selenium Injection should not be given undiluted by direct injection into a peripheral vein because of the potential for infusion phlebitis.

Side effects of Silicon in details

None well documented.

Silicon contraindications

Standard considerations.

What are the possible side effects of Vitamin A?

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bleeding from gums or sore mouth
• bulging soft spot on head (in babies)
• confusion or unusual excitement
• diarrhea
• dizziness or drowsiness
• double vision
• headache (severe)
• irritability (severe)
• peeling of skin, especially on lips and palms
• vomiting (severe)

Check with your doctor as soon as possible if any of the following side effects occur:

• Bone or joint pain
• convulsions (seizures)
• drying or cracking of skin or lips
• dry mouth
• fever
• general feeling of discomfort or illness or weakness
• headache
• increased sensitivity of skin to sunlight
• increase in frequency of urination, especially at night, or in amount of urine
• irritability
• loss of appetite
• loss of hair
• stomach pain
• unusual tiredness
• vomiting
• yellow-orange patches on soles of feet, palms of hands, or skin around nose and lips

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Side effects of Vitamin A in details

This vitamin usually has no side effects when used in recommended doses. If you have any unusual effects, contact your doctor or pharmacist promptly.

A very serious allergic reaction to this vitamin is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

What is the most important information I should know about Vitamin A?

Never take more than the recommended dose of vitamin A. Avoid taking more than one vitamin product at the same time unless your doctor tells you to. Taking similar vitamin products together can result in a vitamin overdose or serious side effects.

An overdose of vitamin A can cause serious or life-threatening side effects.

Do not take vitamin A without medical advice if you are pregnant. Vitamin A can cause birth defects if taken in large doses.

Before taking vitamin A, tell your doctor about all other medicines you use.

Vitamin A contraindications

The intravenous administration. Hypervitaminosis A. Sensitivity to any of the ingredients in this preparation. Use in Pregnancy: Safety of amounts exceeding 6,000 Units of vitamin A daily during pregnancy has not been established at this time. The use of vitamin A in excess of the recommended dietary allowance may cause fetal harm when administered to a pregnant woman. Animal reproduction studies have shown fetal abnormalities associated with overdosage in several species. Malformations of the central nervous system, the eye, the palate, and the urogenital tract are recorded. Vitamin A in excess of the recommended dietary allowance is contraindicated in women who are or may become pregnant. If vitamin A is used during pregnancy, or if the patient becomes pregnant while taking vitamin A, the patient should be apprised of the potential hazard to the fetus.

What are the possible side effects of Vitamin B1?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• blue colored lips;

• chest pain, feeling short of breath;

• black, bloody, or tarry stools; or

• coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

• nausea, tight feeling in your throat;

• sweating, feeling warm;

• mild rash or itching;

• feeling restless; or

• tenderness or a hard lump where a thiamine injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin B1 in details

Applies to thiamine: capsule, solution, tablet, tablet enteric coated

As well as its needed effects, thiamine (the active ingredient contained in Vitamin B1) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking thiamine, check with your doctor immediately:

Rare - Soon after receiving injection only

• Coughing
• difficulty in swallowing
• hives
• itching of skin
• swelling of face, lips, or eyelids
• wheezing or difficulty in breathing

What is the most important information I should know about Vitamin B1?

You should not use thiamine if you have ever had an allergic reaction to it.

Ask a doctor or pharmacist before taking thiamine if you have any medical conditions, if you take other medications or herbal products, or if you are allergic to any drugs or foods.

Before you receive injectable thiamine, tell your doctor if you have kidney disease.

Thiamine is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.

Vitamin B1 contraindications

Contraindications for vitamin B1

Hypersensitivity to vitamin B1 or any component of a product containing vitamin B1.

What are the possible side effects of Vitamin B12?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• numbness or tingling in your hands or feet;

• signs of fluid build-up around your lungs--anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus, chest pain; or

• signs of low Vitamin B12--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling.

Common side effects may include:

• swelling, rapid weight gain;

• diarrhea; or

• itching or mild rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin B12 in details

Applies to cyanocobalamin: intramuscular solution

Other dosage forms:

• nasal gel/jelly, nasal spray

As well as its needed effects, cyanocobalamin (the active ingredient contained in Vitamin B12) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking cyanocobalamin, check with your doctor or nurse immediately:

Incidence not known:

• Abdominal or stomach pain
• bleeding from the gums or nose
• blue lips and fingernails
• chest pain
• cough
• coughing that sometimes produces a pink frothy sputum
• decreased urine output
• difficult, fast, noisy breathing, sometimes with wheezing
• difficulty with swallowing
• dilated neck veins
• dizziness
• extreme fatigue
• eye pain
• fast heartbeat
• headache
• hives, itching, or skin rash
• increased sweating
• irregular breathing
• irregular heartbeat
• pale skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• ringing in the ears
• swelling of the face, fingers, feet, or lower legs
• tightness in the chest
• unusual tiredness or weakness
• weight gain

Minor Side Effects

Some cyanocobalamin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

• Diarrhea
• skin rash with a general disease

What is the most important information I should know about Vitamin B12?

You should not use this medication if you have Leber's disease. Cyanocobalamin can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.

Vitamin B12 contraindications

Hypersensitivity to the components of the formula. History of allergy to the cobalamins (vitamin B12 and similar substances). Malignant tumors. By stimulating the growth of tissues, the Cobamamide could increase the high rate of cell multiplication. Sensitivity to cobalt. History of allergies to cobalamin (vitamin B12 and related substances).

- Malignant tumor: Due to the action of vitamin B12 on the growth of tissue cell multiplication rate high, the risk of exacerbation should be taken into account.

- Children under 6 years because of the dosage form

What are the possible side effects of Vitamin B2?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Riboflavin may cause your urine to become a yellow-orange color. This effect is harmless.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin B2 in details

Genitourinary

Yellow-orange discoloration of urine.

What is the most important information I should know about Vitamin B2?

Use riboflavin as directed on the label, or as your healthcare provider has prescribed. Do not use this product in larger amounts or for longer than recommended.

Vitamin B2 contraindications

None well documented.

What are the possible side effects of Vitamin B6?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• decreased sensation to touch, temperature, and vibration;

• loss of balance or coordination;

• numbness in your feet or around your mouth;

• clumsiness in your hands; or

• feeling tired.

Common side effects may include:

• nausea;

• headache;

• drowsiness; or

• mild numbness or tingling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin B6 in details

Applies to pyridoxine: capsule, injectable, solution, tablet, tablet enteric coated, tablet extended release

As well as its needed effects, pyridoxine (the active ingredient contained in Vitamin B6) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking pyridoxine, check with your doctor or nurse as soon as possible:

With large doses

• Clumsiness
• numbness of hands or feet

What is the most important information I should know about Vitamin B6?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Vitamin B6 contraindications

Contraindications for vitamin B6

Vitamin B6 is contraindicated in those hypersensitive to any component of a vitamin B6-containing product.

What are the possible side effects of Vitamin C?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using ascorbic acid and call your doctor at once if you have:

• joint pain, weakness or tired feeling, weight loss, stomach pain;

• chills, fever, increased urge to urinate, painful or difficult urination; or

• severe pain in your side or lower back, blood in your urine.

Common side effects may include:

• heartburn, upset stomach; or

• nausea, diarrhea, stomach cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin C in details

Applies to ascorbic acid: oral capsule, oral capsule extended release, oral capsule liquid filled, oral granule, oral liquid, oral lozenge/troche, oral powder, oral powder for solution, oral powder for suspension, oral solution, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release, oral wafer

As well as its needed effects, ascorbic acid (the active ingredient contained in Vitamin C) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking ascorbic acid, check with your doctor or nurse as soon as possible:

Less common or rare: - with high doses

• Side or lower back pain

Minor Side Effects

Some ascorbic acid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common or rare: - with high doses

• Diarrhea
• dizziness or faintness (with the injection only)
• flushing or redness of skin
• headache
• increase in urination (mild)
• nausea or vomiting
• stomach cramps

What is the most important information I should know about Vitamin C?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Vitamin C contraindications

AV-block II and III degree, sinoatrial block, SSS, bradycardia (HR < 40 bpm), hypotension (in case of myocardial infarction, systolic blood pressure less than 100 mm Hg), cardiogenic shock, congestive heart failure IIB-III stages, acute heart failure, Prinzmetal's angina, lactation, concomitant use of MAO inhibitors, hypersensitivity to atenolol.

What are the possible side effects of Vitamin D?

Along with its needed effects, a dietary supplement may cause some unwanted effects. Alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, and ergocalciferol do not usually cause any side effects when taken as directed. However, taking large amounts over a period of time may cause some unwanted effects that can be serious.

Check with your doctor immediately if any of the following side effects occur:

Late symptoms of severe overdose

• High blood pressure
• high fever
• irregular heartbeat
• stomach pain (severe)

Check with your doctor as soon as possible if any of the following side effects occur:

Early symptoms of overdose

• Bone pain
• constipation (especially in children or adolescents)
• diarrhea
• drowsiness
• dryness of mouth
• headache (continuing)
• increased thirst
• increase in frequency of urination, especially at night, or in amount of urine
• irregular heartbeat
• itching skin
• loss of appetite
• metallic taste
• muscle pain
• nausea or vomiting (especially in children or adolescents)
• unusual tiredness or weakness

• Bone pain
• Vitamin D deposits (hard lumps) in tissues outside of the bone
• cloudy urine
• drowsiness
• increased sensitivity of eyes to light or irritation of eyes
• itching of skin
• loss of appetite
• loss of sex drive
• mood or mental changes
• muscle pain
• nausea or vomiting
• protein in the urine
• redness or discharge of the eye, eyelid, or lining of the eyelid
• runny nose
• weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Copyright 2016 Truven Health Analytics, Inc. All Rights Reserved.

Side effects of Vitamin D in details

• Metabolism and Nutrition Disorders

Hypercalcaemia

Hyperphosphataemia

• Skin and Subcutaneous Tissue Disorders

Pruritus

Rash

Urticaria

• Renal and Urinary Disorders

Nephrocalcinosis

Renal impairment

Vitamin D contraindications

OTC labeling: Replesta products only: When used for self-medication, do not use if you have hypercalcemia, primary hyperparathyroidism, sarcoidosis, hypervitaminosis D, Williams syndrome, or are pregnant.

Documentation of allergenic cross-reactivity for vitamin D is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.

What are the possible side effects of Vitamin E?

Get emergency medical help if you have any of these signs of an allergic reaction to vitamin E: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking vitamin E and call your doctor at once if you have:

• headache, dizziness, vision changes;

• a light-headed feeling, like you might pass out;

• unusual weakness or tired feeling;

• diarrhea, stomach cramps; or

• easy bruising or bleeding (nosebleeds, bleeding gums).

Common vitamin E side effects may include:

• nausea;

• tired feeling;

• headache; or

• mild rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin E in details

Applies to vitamin e: oral capsule, oral capsule liquid filled, oral liquid, oral powder for solution, oral solution, oral tablet, oral tablet chewable

In addition to its needed effects, some unwanted effects may be caused by vitamin e (the active ingredient contained in Vitamin E). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking vitamin e, check with your doctor or nurse as soon as possible:

With doses greater than 400 Units a day and long-term use

• Blurred vision
• diarrhea
• dizziness
• headache
• nausea or stomach cramps
• unusual tiredness or weakness

What is the most important information I should know about Vitamin E?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Vitamin E contraindications

Hypersensitivity to vitamin E or any component of the formulation

What are the possible side effects of Zinc?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Side effects of Zinc in details

Applies to zinc sulfate: capsules, tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking zinc sulfate (the active ingredient contained in Zinc)

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe vomiting; unusual restlessness; very dry mouth, eyes, or skin.

What is the most important information I should know about Zinc?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Zinc contraindications

Hypersensitivity to any of the ingredients of Zinc.

References

1. DailyMed. "ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN 5'-PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. DailyMed. "COPPER: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
3. DailyMed. "CALCIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology