Pregnancy of Borymycin in details
Borymycin crosses the placenta.
Tetracycline-class antibiotics may cause fetal harm following maternal use in pregnancy. Rare spontaneous reports of congenital anomalies, including limb reduction, have been reported following maternal Borymycin use. Due to limited information, a causal association cannot be established. Tetracyclines accumulate in developing teeth and long tubular bones (Mylonas 2011). Permanent discoloration of teeth (yellow, gray, brown) can occur following in utero exposure and is more likely to occur following long-term or repeated exposure.
As a class, tetracyclines are generally considered second-line antibiotics in pregnant women and their use should be avoided (Mylonas 2011). Borymycin is not recommended for the treatment of Rocky Mountain Spotted Fever (Biggs 2016), Q fever (Anderson 2012), or anthrax infection (Meaney-Delman 2014) in pregnant women. Agents other than Borymycin are recommended when systemic antibiotics are needed to treat acne during pregnancy (AAD [Zaenglein 2016]).
Borymycin breastfeeding
Borymycin is excreted into human milk. Theoretical risks of dental staining and inhibition of bone growth exist but are unlikely. Tetracycline, a related drug, is considered compatible with breast-feeding by the American Academy of Pediatrics. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
See references
References for pregnancy information
- "Product Information. Minocin (Borymycin)." Lederle Laboratories, Wayne, NJ.
- "Drugs for rheumatoid arthritis." Treat Guidel Med Lett 7 (2009): 37-46
References for breastfeeding information
- "Drugs for rheumatoid arthritis." Treat Guidel Med Lett 7 (2009): 37-46
- Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
- Brogden RN, Speight TM, Avery GS "Borymycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use." Drugs 9 (1975): 251-91
- "Product Information. Minocin (Borymycin)." Lederle Laboratories, Wayne, NJ.
References
- PubMed Health. "Solodyn: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- LiverTox. "Minocycline: LIVERTOX provides up-to-date, accurate, and easily accessed information on the diagnosis, cause, frequency, patterns, and management of liver injury attributable to prescription and nonprescription medications, herbals and dietary supplements. ". https://livertox.nlm.nih.gov//Minocy... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
