Bromhexine Hcl/Guaifenesin/Terbutaline Sulfate Uses
How old is patient?
sponsored
Uses
Dosage
Side effects
Pregnancy
Overdose
Actions

Consists of Bromhexine Hcl, Guaifenesin, Terbutaline Sulfate

Bromhexine Hcl indications

sponsored

Poultry: CRD, infectious bronchitis, laryngoteracheitis, infectious coryza, influenza.

Turkey: Infectious sinusitis.

Calves, pigs, lambs, kids and foals: pneumonia, bronchopneumonia, rhinitis and cough.

Uses of Bromhexine Hcl in details

Bromhexine Hcl is used to treat breathing difficulties caused by excessive mucus secretions in the air passages associated with respiratory tract infections.

Bromhexine Hcl description

Each tablet also contains lactose, maize or potato starch, gelatine and magnesium stearate as excipients.

The oral/inhalation solution also contains tartaric acid and methyl parahydroxybenzoate as excipients.

The syrup also contains tartaric acid, benzoic acid, sodium carboxymethylcellulose, glycerol, sorbitol solution, pharma flavor and ethanol as excipients.

Each capsule also contains lactose, cornstarch and magnesium stearate as excipients.

Bromhexine Hcl HCl is N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)amine hydrochloride.

Bromhexine Hcl dosage

Unless otherwise prescribed, the following doses are recommended:

Tablet: Adults and Children >12 years: 8 mg (1 tab) thrice daily; 6-12 years: 4 mg (½ tab) thrice daily; 2-6 years: 4 mg (½ tab) twice daily.

Oral Solution:

Adults and Children >12 years: 4 mL thrice daily; 6-12 years: 2 mL thrice daily; 2-6 years: 20 drops thrice daily; <2 years: 10 drops thrice daily.

Inhalation Solution (with aerosol apparatus): It is generally recommended to warm inhalation solution to body temperature before inhalation. Patients with bronchial asthma may be advised to commencing inhalation after they have taken their regular bronchospasmolytic therapy.

Adults: 4 mL. Children >12 years: 2 mL; 6-12 years: 1 mL; 2-6 years: 10 drops; <2 years: 5 drops. All doses to be taken twice daily.

The solution may be diluted 1:1 in physiological saline solution. In order to avoid precipitation, the solution should be inhaled immediately after mixing. The combined administration of inhalation and oral application intensifies the effect, and is especially suited for the commencement of treatment in cases where the full effect is to be reached quickly.

Syrup: Adults and Children >12 years: 5 ml (1 tsp) thrice daily.

At commencement of treatment, it may be necessary to increase the total daily dose up to 48 mg in adults.

The syrup is sugar-free and therefore suitable for diabetics and small children.

Ampoule: Severe cases, before and after surgical intervention: 1 amp SC, IM or IV (duration of injection: 2-3 min) 2-3 times daily.

Capsule: Adults: 1 cap 3 times daily.

It is recommended for the initial phase of treatment usually lasting not more than a week.

Patients being treated with Bromhexine Hcl should be notified of an expected increase in the flow of secretions.

Bromhexine Hcl interactions

sponsored

A reduction in dose of cardiac glycosides (e.g. digitalis) and quinidine might become necessary in patients suffering from congestive cardiac failure because of the positive inotropic effect of orciprenaline sulphate.

Bromhexine Hcl hydrochloride SYRUP should not be administered concomitantly with beta-blocking agents, due to orciprenaline’s reversal of anti-hypertensive action.

The concomitant use of other sympathomimetic agents should be carefully controlled to avoid potentiation of effects.

Bromhexine Hcl side effects

Bromhexine Hcl’s pharmacological action may lead to gastric irritation. A transient rise in serum aminotransferase values have been reported due to Bromhexine Hcl.

Orciprenaline sulphate, as a sympathomimetic agent, may precipitate a wide range of adverse effects. Side-effects include fear; anxiety, restlessness, tremor, insomnia, confusion, irritability, weakness and psychotic states. Appetite may be reduced and nausea and vomiting may occur. A rise in blood pressure which may produce cerebral haemorrhage and pulmonary oedema, tachycardia and cardiac arrhythmias, anginal pain, palpitations, and cardiac arrest. Hypotension with dizziness and fainting and flushing may occur. Other effects that may occur include difficulty in micturition and urinary retention; dyspnoea; weakness; headache; disturbances of glucose metabolism; sweating and hypersalivation. Muscle cramps or twitching or unpleasant taste may occur.

Bromhexine Hcl contraindications

sponsored

Bromhexine Hcl hydrochloride SYRUP is contra-indicated in patients with known hypersensitivity to sympathomimetic amines or any of the other ingredients; hypertrophic obstructive cardiomyopathy; and tachyarrhythmia.

Sympathomimetics, such as orciprenaline sulphate, may interact with monoamine oxidase inhibitors (MAOI), and therefore Bromhexine Hcl hydrochloride SYRUP should not be given to patients receiving such treatment or within 14 days of MAOI treatment termination.

Safety in pregnancy and lactation has not been established.

What is Guaifenesin?

Geri-Guaifenesin Expectorant is used to reduce chest congestion caused by the common cold, flu, or chronic bronchitis.

Geri-Guaifenesin Expectorant helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

There are many brands and forms of guaifenesin available. Not all brands are listed on this leaflet.

Geri-Guaifenesin Expectorant may also be used for purposes not listed in this medication guide.

Guaifenesin indications

Guaifenesin and hydrocodone is used to treat cough and reduce chest congestion caused by the common cold, flu, or allergies.

How should I use Guaifenesin?

Use Guaifenesin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Guaifenesin.

Uses of Guaifenesin in details

sponsored

Guaifenesin is used to treat coughs and congestion caused by the common cold, bronchitis, and other breathing illnesses. This product is usually not used for ongoing cough from smoking or long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by your doctor. Guaifenesin is an expectorant. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier.

If you are self-treating with this medication, it is important to read the package instructions carefully before you start using this product to be sure it is right for you.

Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.

These products do not cure or shorten the length of the common cold. To decrease the risk for side effects, carefully follow all dosage directions. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

How to use 2/G

Take this medication by mouth with or without food, as directed by your doctor, usually every 4 hours. If you are self-treating, follow all directions on the product package. If you are uncertain about any of the information, ask your doctor or pharmacist.

Guaifenesin may have a bitter taste. Do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

For powder packets, empty the entire contents of the packet onto the tongue and swallow. To prevent a bitter taste, do not chew.

Dosage is based on your age, medical condition, and response to treatment. Do not take more than 6 doses in a day. Do not increase your dose or take this drug more often than directed.

Drink plenty of fluids while taking this medication. Fluids will help to break up mucus and clear congestion.

Tell your doctor if your cough is accompanied by fever, severe sore throat, rash, persistent headache, or if it persists, returns, or worsens after 7 days. These may be signs of a serious medical problem. Seek immediate medical attention if you think you may have a serious medical problem.

Guaifenesin description

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Guaifenesin is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Guaifenesin dosage

Guaifenesin Dosage

Generic name: Guaifenesin 600mg

Dosage form: tablet, extended release

See also:

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

More about Guaifenesin (guaifenesin)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Guaifenesin interactions

See also:
What other drugs will affect Guaifenesin?

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Guaifenesin is available in both prescription and nonprescription products. Check the labels of all your medications to make sure you are not taking more than one product containing guaifenesin.

This product can affect the results of certain lab tests (such as urine levels of certain acids). Make sure laboratory personnel and all your doctors know you use this drug.

Keep a list of all the products you use. Share the list with your doctor and pharmacist to reduce your risk for serious medication problems.

Guaifenesin side effects

See also:
What are the possible side effects of Guaifenesin?

Applies to guaifenesin: oral liquid, oral packet, oral solution, oral syrup, oral tablet, oral tablet extended release

Side effects requiring immediate medical attention

Along with its needed effects, guaifenesin (the active ingredient contained in Guaifenesin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Side effects not requiring immediate medical attention

Some side effects of guaifenesin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

Managing side effects (general information)

Guaifenesin contraindications

See also:
What is the most important information I should know about Guaifenesin?

Guaifenesin is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other ingredient in DOLOPHINE.

Guaifenesin is contraindicated in any situation where opioids are contraindicated such as: patients with respiratory depression (in the absence of resuscitative equipment or in unmonitored settings), and in patients with acute bronchial asthma or hypercarbia.

Guaifenesin is contraindicated in any patient who has or is suspected of having a paralytic ileus.

What is Terbutaline Sulfate?

Terbutaline Sulfate injection is used to prevent bronchospasm in patients 12 years of age and older with asthma, bronchitis, emphysema, and other lung diseases.

Terbutaline Sulfate belongs to the family of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

Terbutaline Sulfate is available only with your doctor's prescription.

Terbutaline Sulfate indications

Oral

Acute bronchospasm

Adult: Initially, 2.5 mg or 3 mg tid, up to 5 mg tid as necessary. As modified-release tab: 5 mg or 7.5 mg bid.

Child: <12 yr Initially, 0.05 mg/kg/dose tid, increase gradually as required. Max: 5 mg/day; 12-15 yr 2.5 mg tid; >15 yr Same as adult dose.

Inhalation

Acute bronchospasm

Adult: As metered-dose powd inhaler: 250-500 mcg as required. Max: 2,000 mcg daily.

Parenteral

Severe bronchospasm

Adult: 250-500 mcg up to 4 times daily by SC, IM or IV inj, or by IV infusion as a soln containing 3-5 mcg/mL at a rate of 0.5-1 mL/min.

Child: 2-15 yr 0.01 mg/kg. Max: 0.3 mg/dose.

Reconstitution: Add 10 mL of Terbutaline Sulfate soln for inj to 40 mL of dextrose 5% if using a syringe pump or to 490 mL of dextrose 5% if syringe pump is not available.

Intravenous

Uncomplicated premature labour

Adult: To arrest labour between 22-37 wk of gestation: Initially, 5 mcg/min, w/ increments of 2.5 mcg/min at 20 min intervals until contractions stop. Max: 20 mcg/min. Continue for 1 hr after contractions have ceased, then decrease by 2.5 mcg/min every 20 min to lowest dose that maintains suppression. Max duration: 48 hr.

Reconstitution: Add 10 mL of Terbutaline Sulfate soln for inj to 40 mL of dextrose 5% if using a syringe pump or to 490 mL of dextrose 5% if syringe pump is not available.

Inhalation

Severe bronchospasm

Adult: As 1% nebuliser soln: 2.5-10 mg 2-4 times daily.

Child: <25 kg: 2-5 mg 2-4 times daily; ≥25 kg: 5 mg 2-4 times daily.

How should I use Terbutaline Sulfate?

Use Terbutaline Sulfate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Terbutaline Sulfate.

Uses of Terbutaline Sulfate in details

Use: Labeled Indications

Asthma/Bronchospasm: Prevention and reversal of bronchospasm in patients ≥12 years of age with asthma and reversible bronchospasm associated with bronchitis and emphysema

Off Label Uses

Extravasation management, sympathomimetic vasoconstrictors

Data from a limited number of patients suggests that Terbutaline Sulfate may be beneficial for the management of extravasation of sympathomimetic vasoconstrictors.

Terbutaline Sulfate description

A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. [PubChem]

Terbutaline Sulfate dosage

Terbutaline Sulfate Dosage

Applies to the following strength(s): 2.5 mg; 5 mg; 0.2 mg/inh; 1 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Asthma - Maintenance

Tablets: 5 mg orally 3 times a day at 6 hour intervals during waking hours. May decrease to 2.5 mg/dose if side effects are pronounced. Do not exceed 15 mg in 24 hours.

Inhalation aerosol: 2 inhalations separated by 60 seconds every 4 to 6 hours. Do not repeat more often than every 4 to 6 hours.

Usual Adult Dose for Premature Labor

Tablets: 2.5 to 7.5 mg orally every 6 hours. Therapy should be continued until 36 to 37 weeks gestation.

Continuous intravenous infusion: 10 to 25 mcg/min. Therapy should be continued until labor has been arrested. Maximum dose 80 mcg/min.

Subcutaneous injection: 0.25 mg every 6 hours. Subcutaneous therapy should be continued until labor has been arrested.

Usual Adult Dose for Asthma - Acute

Inhalation aerosol: 2 inhalations separated by 60 seconds every 4 to 6 hours. Do not repeat more often than every 4 to 6 hours.

Subcutaneous Injection: 0.25 mg into the lateral deltoid area. A second 0.25 mg dose can be administered in 15 to 30 minutes if needed. Do not exceed 0.5 mg in 4 hours.

Continuous intravenous infusion: 0.08 to 6 mcg/kg/min.

Usual Pediatric Dose for Asthma - Acute

Subcutaneous Injection: 0.005 to 0.01 mg/kg/dose to a maximum dose of 0.4 mg every 15 to 20 minutes for 2 doses.

Nebulization: 0.01 to 0.03 mg/kg/dose with a minimum dose of 0.1 mg; maximum dose is 2.5 mg diluted with 1 to 2 mL of normal saline every 4 to 6 hours.

Continuous intravenous infusion: 0.08 to 6 mcg/kg/min.

> 12 years:

Inhalation aerosol: 2 inhalations separated by 60 seconds every 4 to 6 hours. Do not repeat more often than every 4 to 6 hours.

Subcutaneous Injection: 0.25 mg into the lateral deltoid area. A second 0.25 mg dose can be administered in 15-30 minutes if needed. Maximum dose 0.5 mg in 4 hours.

Usual Pediatric Dose for Asthma - Maintenance

< 12 years:

Tablets: 0.05 mg/kg/day divided into three doses. Gradually increase to 0.15 mg/kg/day. Maximum dose is 5 mg per day.

>=12 years:

Inhalation aerosol: 2 inhalations separated by 60 seconds every 4 to 6 hours. Do not repeat more often than every 4 to 6 hours.

>=12 <15 years:

Tablets: 2.5 mg orally every 6 to 8 hours. Do not exceed 7.5 mg in 24 hours

>=15 years:

Tablets: 2.5 mg to 5 mg orally every 6 to 8 hours. Do not exceed 15 mg in 24 hours.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Terbutaline Sulfate is not approved by the FDA for use as a tocolytic agent. Although Terbutaline Sulfate and other beta-agonists have been shown to be effective in arresting episodes of premature labor, there are few studies which evaluate its use for maintenance therapy after successful treatment of an episode of premature labor. A meta-analysis of those few studies did not support its use for maintenance therapy.

Dialysis

Data not available

More about Terbutaline Sulfate

Consumer resources

Professional resources

Related treatment guides

Terbutaline Sulfate interactions

See also:
What other drugs will affect Terbutaline Sulfate?

The concomitant use of Terbutaline Sulfate with other sympathomimetic agents is not recommended, since the combined effect on the cardiovascular system may be deleterious to the patient.

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants

Terbutaline Sulfate should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, since the action of Terbutaline Sulfate on the vascular system may be potentiated.

Beta-Blockers

Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as Terbutaline Sulfate, but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution.

Diuretics

The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.

Terbutaline Sulfate side effects

See also:
What are the possible side effects of Terbutaline Sulfate?

Adverse reactions observed with Terbutaline Sulfate sulfate injection are similar to those commonly seen with other sympathomimetic agents. All these reactions are transient in nature and usually do not require treatment. The following table compares adverse reactions seen in patients treated with Terbutaline Sulfate sulfate injection (0.25 mg and 0.5 mg), with those seen in patients treated with epinephrine injection (0.25 mg and 0.5 mg), during eight double-blind crossover studies involving a total of 214 patients.

Note: Some patients received more than one dosage strength of Terbutaline Sulfate sulfate and epinephrine. In addition, there were reports of anxiety, muscle cramps, and dry mouth (<0.5%). There have been rare reports of elevations in liver enzymes and of hypersensitivity vasculitis with Terbutaline Sulfate administration.

Incidence (%) of Adverse Reactions

Terbutaline Sulfate (%)

Epinephrine (%)

0.25 mg

N=77

0.5 mg

N=205

0.25 mg

N=153

0.5 mg

N=61

Reaction

Central Nervous System

Tremor

7.8

38.0

16.3

18.0

Nervousness

16.9

30.7

8.5

31.1

Dizziness

1.3

10.2

7.8

3.3

Headache

7.8

8.8

3.3

9.8

Drowsiness

11.7

9.8

14.4

8.2

Cardiovascular

Palpitations

7.8

22.9

7.8

29.5

Tachycardia

1.3

1.5

2.6

0.0

Respiratory

Dyspnea

0.0

2.0

2.0

0.0

Chest discomfort

1.3

1.5

2.6

0.0

Gastrointestinal

Nausea/vomiting

1.3

3.9

1.3

11.5

Systemic

Weakness

1.3

0.5

2.6

1.6

Flushed feeling

0.0

2.4

1.3

0.0

Sweating

0.0

2.4

0.0

0.0

Pain at injection site

2.6

0.5

2.6

1.6

Terbutaline Sulfate contraindications

See also:
What is the most important information I should know about Terbutaline Sulfate?

1.
Prolonged Tocolysis

Terbutaline Sulfate sulfate has not been approved for and should not be used for prolonged tocolysis (beyond 48-72 hours). In particular, Terbutaline Sulfate sulfate should not be used for maintenance tocolysis in the outpatient or home setting.

2.
Hypersensitivity

Terbutaline Sulfate sulfate injection is contraindicated in patients known to be hypersensitive to sympathomimetic amines or any component of this drug product.

Active ingredient matches for Bromhexine Hcl/Guaifenesin/Terbutaline Sulfate:

Bromhexine Hcl/Guaifenesin/Terbutaline Sulfate


References

  1. DailyMed. "TERBUTALINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "GUAIFENESIN; HYDROCODONE BITARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "terbutaline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Bromhexine Hcl/Guaifenesin/Terbutaline Sulfate are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Bromhexine Hcl/Guaifenesin/Terbutaline Sulfate. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


Consumer reported time for results

No survey data has been collected yet


Consumer reported age

No survey data has been collected yet


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 7 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

More about Bromhexine Hcl/Guaifenesin/Terbutaline Sulfate

  • Bromhexine Hcl/Guaifenesin/Terbutaline Sulfate generic and brand names

    • Share on Facebook Tweet

    | Privacy Policy
    This site does not supply any medicines. It contains prices for information purposes only.
    © 2003 - 2024 ndrugs.com All Rights Reserved