Bronchi Mereprine indications
Bronchi Mereprine hydrochloride SYRUP indicated for cough associated with wheeziness (bronchospasm) and tenacious phlegm (sputum).
Uses of Bronchi Mereprine in details
Bronchi Mereprine is used to treat breathing difficulties caused by excessive mucus secretions in the air passages associated with respiratory tract infections.
Bronchi Mereprine description
Each tablet also contains lactose, maize or potato starch, gelatine and magnesium stearate as excipients.
The oral/inhalation solution also contains tartaric acid and methyl parahydroxybenzoate as excipients.
The syrup also contains tartaric acid, benzoic acid, sodium carboxymethylcellulose, glycerol, sorbitol solution, pharma flavor and ethanol as excipients.
Each capsule also contains lactose, cornstarch and magnesium stearate as excipients.
Bronchi Mereprine HCl is N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)amine hydrochloride.
Bronchi Mereprine dosage
Unless otherwise prescribed, the following doses are recommended:
Tablet: Adults and Children >12 years: 8 mg (1 tab) thrice daily; 6-12 years: 4 mg (½ tab) thrice daily; 2-6 years: 4 mg (½ tab) twice daily.
Oral Solution:
Adults and Children >12 years: 4 mL thrice daily; 6-12 years: 2 mL thrice daily; 2-6 years: 20 drops thrice daily; <2 years: 10 drops thrice daily.Inhalation Solution (with aerosol apparatus): It is generally recommended to warm inhalation solution to body temperature before inhalation. Patients with bronchial asthma may be advised to commencing inhalation after they have taken their regular bronchospasmolytic therapy.
Adults: 4 mL. Children >12 years: 2 mL; 6-12 years: 1 mL; 2-6 years: 10 drops; <2 years: 5 drops. All doses to be taken twice daily.
The solution may be diluted 1:1 in physiological saline solution. In order to avoid precipitation, the solution should be inhaled immediately after mixing. The combined administration of inhalation and oral application intensifies the effect, and is especially suited for the commencement of treatment in cases where the full effect is to be reached quickly.
Syrup: Adults and Children >12 years: 5 ml (1 tsp) thrice daily.
At commencement of treatment, it may be necessary to increase the total daily dose up to 48 mg in adults.
The syrup is sugar-free and therefore suitable for diabetics and small children.
Ampoule: Severe cases, before and after surgical intervention: 1 amp SC, IM or IV (duration of injection: 2-3 min) 2-3 times daily.
Capsule: Adults: 1 cap 3 times daily.
It is recommended for the initial phase of treatment usually lasting not more than a week.
Patients being treated with Bronchi Mereprine should be notified of an expected increase in the flow of secretions.
Bronchi Mereprine interactions
A reduction in dose of cardiac glycosides (e.g. digitalis) and quinidine might become necessary in patients suffering from congestive cardiac failure because of the positive inotropic effect of orciprenaline sulphate.
Bronchi Mereprine hydrochloride SYRUP should not be administered concomitantly with beta-blocking agents, due to orciprenaline’s reversal of anti-hypertensive action.
The concomitant use of other sympathomimetic agents should be carefully controlled to avoid potentiation of effects.
Bronchi Mereprine side effects
Bronchi Mereprine’s pharmacological action may lead to gastric irritation. A transient rise in serum aminotransferase values have been reported due to Bronchi Mereprine.
Orciprenaline sulphate, as a sympathomimetic agent, may precipitate a wide range of adverse effects. Side-effects include fear; anxiety, restlessness, tremor, insomnia, confusion, irritability, weakness and psychotic states. Appetite may be reduced and nausea and vomiting may occur. A rise in blood pressure which may produce cerebral haemorrhage and pulmonary oedema, tachycardia and cardiac arrhythmias, anginal pain, palpitations, and cardiac arrest. Hypotension with dizziness and fainting and flushing may occur. Other effects that may occur include difficulty in micturition and urinary retention; dyspnoea; weakness; headache; disturbances of glucose metabolism; sweating and hypersalivation. Muscle cramps or twitching or unpleasant taste may occur.
Bronchi Mereprine contraindications
Bronchi Mereprine hydrochloride SYRUP is contra-indicated in patients with known hypersensitivity to sympathomimetic amines or any of the other ingredients; hypertrophic obstructive cardiomyopathy; and tachyarrhythmia.
Sympathomimetics, such as orciprenaline sulphate, may interact with monoamine oxidase inhibitors (MAOI), and therefore Bronchi Mereprine hydrochloride SYRUP should not be given to patients receiving such treatment or within 14 days of MAOI treatment termination.
Safety in pregnancy and lactation has not been established.
Active ingredient matches for Bronchi Mereprine:
Bromhexine in Belgium.
List of Bronchi Mereprine substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Bronchi-Mereprine (Belgium) | |
| Broncho Solvin | |
| Broncho Solvin 100+8+2.5 Tablet (IPCA Laboratories Ltd.) | $ 0.02 |
| Bronchodian | |
| Bronchodian 100 ml Syrup (Meri Odin Life Sciences) | $ 0.02 |
| Bronchofit (India) | |
| Bronchofit 100 ml Suspension (Pharmatech Healthcare) | $ 0.04 |
| Bronchofit 60 ml Suspension (Pharmatech Healthcare) | $ 0.05 |
| BRONCHOFIT syr 100ml (Pharmatech Healthcare) | $ 0.54 |
| BRONCHOFIT syr 60ml (Pharmatech Healthcare) | $ 0.39 |
| Bronchohexin 8mg voor honden en katten (Netherlands) | |
| Broncholik | |
| Broncholik 100 ml Syrup (SPS Medipol Pvt. Ltd.) | $ 0.03 |
| Bronchosan (Czech Republic, Slovakia) | |
| Drops; Oral; Anise Oil 0.25 mg; Bromhexine Hydrochloride 8 mg; Eucalyptus Oil 0.25 mg; Fennel Oil 0.75 mg; Menthol 1.5 mg; Origanum Oil 0.25 mg; Peppermint Oil 0.25 mg / g (Vitasan) | |
| Bronchosan 25 ml - 1 Drops (Vitasan) | $ 10.40 |
| Bronchosol-BR | |
| Bronchosol-BR 2+8 Tablet (Tosc International Pvt Ltd.) | $ 0.01 |
| Bronchotussine (Greece, Malta) | |
| Bronclear (Pakistan, Thailand) | |
| Bronclear 8 mg x 1, 000's (Polipharm) | |
| Bronco Magimox (Peru) | |
| Broncobiot (Peru) | |
| Broncocalmine (Argentina) | |
| Broncocalmine Oriental (Argentina) | |
| Broncoff | |
| Broncoff 60 ml Syrup (Kylsans Laboratories Ltd) | $ 0.04 |
| Broncogard | |
| Broncogard 100 ml Syrup (Nimbles Biotech Pvt Ltd) | $ 0.05 |
| Broncokin (Italy) | |
| Broncomet (Bangladesh) | |
| Broncophar Pediátrico (Peru) | |
| Broncosolvan (Uruguay) | |
| Broncotosil (Ecuador) | |
| Broncovin | |
| Broncovin 60 ml Syrup (Nexus (India)) | $ 0.02 |
| Brondilax (Argentina) | |
| Bronhall (Greece) | |
| Bronhosolv (Romania) | |
| Bronkase (Thailand) | |
| Bronkase 4 mg/5 mL x 60 mL x 12's | |
| Bronkate | |
| Bronkate 100 ml Syrup (Porsche Pharmaceuticals) | $ 0.03 |
| Bronkese (South Africa) | |
| Bronkese 169.4+50.6 Injection (Tribhawan Injectables) | $ 0.04 |
| Bronkonil Cough | |
| Bronkonil Cough 100 ml Expectorant (Jarson Pharmaceuticals) | $ 0.40 |
| Bronkoril | |
| Bronkoril 100 ml Syrup (Hamax Pharmaceuticals) | $ 0.00 |
| Bronkoril Plus | |
| Bronkoril Plus 100 ml Syrup (Hamax Pharmaceuticals) | $ 0.00 |
| Bronkosyrup EX | |
| Bronkosyrup EX 100 ml Syrup (Glaxo Smithkline Pharmaceuticals Ltd.) | $ 0.01 |
| Bronkosyrup-EX (India) | |
| Bronkosyrup-EX Salbutamol 2 mg, guaiphenesin100 mg, Bromhexinehydrochloride 4 mg/10 mL. SYR / 100ml (GSK) | $ 0.15 |
| 100ml (GSK) | $ 0.15 |
| BRONKOSYRUP-EX syr 100ml (GSK) | $ 0.15 |
| Bronkris (Indonesia) | |
| Bronkris 8 mg x 10 x 10's | $ 0.88 |
| Bronkris 4 mg/5 mL x 60 mL x 1's | $ 1.69 |
| Bronmucon (Thailand) | |
| Bronmucon 8 mg x 500's | |
See 1877 substitutes for Bronchi Mereprine | |
References
- PubChem. "bromhexine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Bromhexine". http://www.drugbank.ca/drugs/DB09019 (accessed September 17, 2018).
- MeSH. "Expectorants". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
