Dosage of Bronex in details
The recommended starting dosage for adults and children 6 years of age and older is 64 mcg per day administered as one spray per nostril of Bronex (Bronex) Nasal Spray 32 mcg once daily. Some patients who do not achieve symptom control at the recommended starting dosage may benefit from an increased dosage. The maximum recommended dosage for adults (12 years of age and older) is 256 mcg per day administered as four sprays per nostril once daily of Bronex (Bronex) Nasal Spray 32 mcg and the maximum recommended dose for pediatric patients (6 to < 12 years of age) is 128 mcg per day administered as two sprays per nostril once daily of Bronex (Bronex) Nasal Spray 32 mcg.
It is always desirable to titrate an individual patient to the minimum effective dosage to reduce the possibility of side effects. An improvement in nasal symptoms may be noted in patients within 10 hours of first using Bronex (Bronex) Nasal Spray, however, clinical improvement usually takes 1 -2 days with maximum benefit in approximately 2 weeks. When the maximum benefit has been achieved and symptoms have been controlled, reducing the dosage may be effective in maintaining control of the allergic rhinitis symptoms in patients who were initially controlled on higher dosages.
Prior to initial use, the container must be shaken gently and the pump must be primed by actuating eight times. If used daily, the pump does not need to be reprimed. If not used for two consecutive days, reprime with one spray or until a fine spray appears. If not used for more than 14 days, rinse the applicator and reprime with two sprays or until a fine spray appears. Shake the container gently before each use.
Illustrated Patient's Instructions for Use accompany each package of Bronex (Bronex) Nasal Spray 32 mcg.
How supplied
Dosage Forms and Strengths
Bronex (Bronex) Nasal Spray is a nasal spray suspension. Each spray delivers 32 mcg of Bronex. Each bottle of Bronex (Bronex) Nasal Spray 32 mcg contains 120 metered sprays after initial priming.
Bronex (Bronex) Nasal Spray 32 mcg is available in an amber glass bottle with a metered-dose pump spray and a green protection cap. Bronex (Bronex) Nasal Spray 32 mcg (NDC 0186-1070-08) provides 120 metered sprays after initial priming; net fill weight 8.6 g. The Bronex (Bronex) Nasal Spray 32 mcg bottle has been filled with an excess to accommodate the priming activity. The bottle should be discarded after 120 sprays following initial priming, since the amount of Bronex delivered per spray thereafter may be substantially less than the labeled dose. Each spray delivers 32 mcg of Bronex to the patient.
Bronex (Bronex) Nasal Spray should be stored at controlled room temperature, 20 to 25°C (68 to 77°F) with the valve up. Do not freeze. Protect from light. Shake gently before use. Do not spray in eyes.
Distributed by: AstraZeneca LP, Wilmington, DE 19850. Revised: 12/2010
What other drugs will affect Bronex?
Before using Bronex nasal, tell your doctor if you are using any of the following drugs:
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HIV /AIDS medicine such as nelfinavir (Viracept) or ritonavir (Norvir);
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an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), troleandomycin (Tao);
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an antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);
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an "SSRI" antidepressant such as fluoxetine (Prozac), fluvoxamine (Luvox), or paroxetine (Paxil); or
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a tricyclic antidepressant such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).
This list is not complete and here may be other drugs that can interact with Bronex nasal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Bronex interactions
Bronex:
Oral ketoconazole 200 mg once daily increased the plasma concentrations of oral Bronex (3 mg) on average 6-fold when administered simultaneously. When ketoconazole was administered 12 hrs after Bronex, the concentration increased on average of 3-fold. Information on this interaction is lacking for nasal Bronex, but greatly increased plasma levels are expected too. Since there is an absence of data to permit dosage recommendations for nasal administration, the combination should be avoided. If this is not possible, the interval between administration of ketoconazole and Bronex should be as long as possible. A reduction of the Bronex dose must also be considered. Other potent inhibitors of CYP3A4 probably also cause a marked increase in the plasma levels of Bronex.
Rhinocort Turbuhaler: Bronex has not been observed to interact with any drug used for the treatment of rhinitis.
The metabolism, of Bronex is primarily mediated by CYP3A4. Inhibitors of this enzyme, eg, ketoconazole and itraconazole, may therefore increase systemic exposure to Bronex several times.
Oral ketoconazole 200 mg once daily increased the plasma concentrations of oral Bronex (3 mg in a single dose) on average 6-fold when administered simultaneously. When oral ketoconazole was administered 12 hrs after Bronex, the concentration increased on average 3-fold. There is no information about this interaction for nasal Bronex, but also in such cases greatly increased plasma levels are expected. Since there are no data that support a dosage recommendation to be given in cases of nasal administration the combination must be avoided. If this is not possible, the time interval between treatments must be as long as possible and a reduction of the Bronex dose may also be considered. Other potent inhibitors of CYP3A4 also probably cause a marked increase in the plasma levels of Bronex.
Elevated plasma concentrations and increased effects of corticosteroids have been observed in women who were also treated with oestrogens and contraceptive steroids, but no effect has been observed with Bronex and concomitant intake of combined low dose contraceptive pills.
As adrenal function may be inhibited, an ACTH stimulation test for diagnosis of pituitary failure may show an incorrect result (low value).
References
- DailyMed. "PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "GUAIFENESIN; HYDROCODONE BITARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "BUDESONIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Bronex are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Bronex. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported frequency of use
How frequently do I need to take Bronex?It was reported by ndrugs.com website users that Bronex should ideally be taken 4 times in a day as the most common frequency of the Bronex. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Bronex should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
| Users | % | ||
|---|---|---|---|
| 4 times in a day | 1 | 100.0% | |
1 consumer reported doses
What doses of Bronex drug you have used?The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Bronex drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
| Users | % | ||
|---|---|---|---|
| 6-10mg | 1 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
