Overdose of Bronkris in details
No symptoms of overdosage have been reported in man to date. If they occur, symptomatic treatment should be provided.
Bronkris warnings
Bronkris hydrochloride should be avoided or used with caution in patients undergoing anaesthesia with cyclopropane, halothane or other halogenated anaesthetics, as it may induce ventricular fibrillation. An increased risk of arrhythmias may also occur if given to patients receiving cardiac glycosides, quinidine or tricyclic antidepressants.
Hypokalaemia may be induced by higher than recommended doses of beta-agonists, especially in patients receiving digitalis glycosides or diuretics or are prone to cardiac dysrrhythmias.
Caution should be exercised in patients suffering from hyperthyroidism due to sympathomimetic effects of orciprenaline sulphate.
Caution should be observed in patients with gastric ulcer due to the Bronkris hydrochloride mucolytic action.
In addition, care should be observed in patients suffering from cardiovascular diseases i.e. ischaemic heart disease; arrhythmias or tachycardia; occlusive vascular disorders including arteriosclerosis, hypertension or aneurysms. Anginal pain may be precipitated in patients suffering from angina pectoris.
Care is also required when Bronkris hydrochloride SYRUP is given to patients with diabetes mellitus or closed angle glaucoma.
Caution is also needed in patients with convulsive disorders.
Bronkris precautions
Use in pregnancy & lactation: Available preclinical studies as well as clinical experience to date have shown no evidence of ill-effects during pregnancy. Nonetheless, the usual precautions regarding the use of drugs during pregnancy, especially during the 1st trimester, should be observed.
Bronkris is expected to enter breast milk and thus should be avoided during lactation.
References
- DrugBank. "Bromhexine". http://www.drugbank.ca/drugs/DB09019 (accessed September 17, 2018).
- MeSH. "Expectorants". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
