Consists of Phenazopyridine, Trimethoprim
What happens if I overdose Phenazopyridine (Carmurit T)?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bluish coloring of the skin; vomiting; yellowing of the skin or eyes.
Proper storage of Phenazopyridine (Carmurit T):
Store Phenazopyridine (Carmurit T) at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Phenazopyridine (Carmurit T) out of the reach of children and away from pets.
Overdose of Phenazopyridine (Carmurit T) in details
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include unusual tiredness, skin color changes, change in the amount of urine, shortness of breath, fast heartbeat, yellowing skin/eyes, easy bleeding/bruising, or seizures.
Notes
Do not share this medication with others.
This medication has been prescribed for your current condition only. Do not take it later for another pain-related condition of the urinary tract unless told to do so by your doctor. A different medication may be necessary in those cases.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Storage
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
What should I avoid while taking Phenazopyridine (Carmurit T)?
Avoid wearing soft contact lenses while you are taking Phenazopyridine (Carmurit T). The medication can cause permanent staining of soft contact lenses.
Phenazopyridine (Carmurit T) warnings
Phenazopyridine (Carmurit T) is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of paracetamol is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
What should I discuss with my healthcare provider before taking Phenazopyridine (Carmurit T)?
- If you have an allergy to Phenazopyridine (Carmurit T) or any other part of Phenazopyridine (Carmurit T) (Phenazopyridine (Carmurit T)).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Kidney disease or liver disease.
This is not a list of all drugs or health problems that interact with Phenazopyridine (Carmurit T) (Phenazopyridine (Carmurit T)).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Phenazopyridine (Carmurit T) (Phenazopyridine (Carmurit T)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Phenazopyridine (Carmurit T) precautions
General
A yellowish tinge of the skin or sclera may indicate accumulation due to impaired renal excretion and the need to discontinue therapy. The decline in renal function associated with advanced age should be kept in mind.
NOTE: Patients should be informed that Phenazopyridine (Carmurit T) HCl produces a reddish-orange discoloration of the urine and may stain fabric. Staining of contact lenses has been reported.
Laboratory Test Interaction
Due to its properties as an azo dye, Phenazopyridine (Carmurit T) HCl may interfere with urinalysis based on spectrometry or color reactions.
Carcinogenesis, Mutagenesis, Impairment Of Fertility
Long-term administration of Phenazopyridine (Carmurit T) HCl has induced neoplasia in rats (large intestine) and mice (liver). Although no association between Phenazopyridine (Carmurit T) HCl and human neoplasia has been reported, adequate epidemiological studies along these lines have not been conducted.
Pregnancy Category B
Reproduction studies have been performed in rats at doses up to 50 mg/kg/day and have revealed no evidence of impaired fertility or harm to the fetus due to Phenazopyridine (Carmurit T) HCl. There are, however, no adequate and well controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Nursing Mothers
No information is available on the appearance of Phenazopyridine (Carmurit T) HCl, or its metabolites in human milk.
What happens if I miss a dose of Phenazopyridine (Carmurit T)?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose Trimethoprim (Carmurit T)?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately. Symptoms may include confusion; depression; dizziness; drowsiness; fever, chills, or sore throat; loss of consciousness; severe nausea or vomiting; severe or prolonged headache; unusual bruising or bleeding.
Proper storage of Trimethoprim (Carmurit T):
Store Trimethoprim (Carmurit T) at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Keep in a tight, light-resistant container. Do not store in the bathroom. Keep Trimethoprim (Carmurit T) out of the reach of children and away from pets.
Overdose of Trimethoprim (Carmurit T) in details
Acute
Signs of acute overdosage with Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) may appear following ingestion of 1 gram or more of the drug and include nausea, vomiting, dizziness, headaches, mental depression, confusion and bone marrow depression.
Treatment consists of gastric lavage and general supportive measures. Acidification of the urine will increase renal elimination of Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet). Peritoneal dialysis is not effective and hemodialysis is only moderately effective in eliminating the drug.
Chronic
Use of Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) at high doses and/or for extended periods of time may cause bone marrow depression manifested as thrombocytopenia, leukopenia and/or megaloblastic anemia. If signs of bone marrow depression occur, Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) should be discontinued and the patient should be given leucovorin; 5 to 15 mg leucovorin daily has been recommended by some investigators.
What should I avoid while taking Trimethoprim (Carmurit T)?
Avoid exposure to sunlight or tanning beds. Trimethoprim (Carmurit T) can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Trimethoprim (Carmurit T) warnings
Serious hypersensitivity reactions have been reported rarely in patients on Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) therapy. Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) has been reported rarely to interfere with hematopoiesis, especially when administered in large doses and/or for prolonged periods.
The presence of clinical signs such as sore throat, fever, pallor or purpura may be early indications of serious blood disorders. Complete blood counts should be obtained if any of these signs are noted in a patient receiving Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) and the drug discontinued if a significant reduction in the count of any formed blood element is found.
What should I discuss with my healthcare provider before taking Trimethoprim (Carmurit T)?
Some medical conditions may interact with Trimethoprim (Carmurit T). Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have liver or kidney problems, or blood problems (eg, anemia, porphyria)
- if you have or are at risk for low levels of folate in the blood (eg, you have alcoholism, are elderly, you do not absorb nutrients from food properly, you are in a poor nutritional state, you are taking medicine for seizures)
Some MEDICINES MAY INTERACT with Trimethoprim (Carmurit T). Tell your health care provider if you are taking any other medicines, especially any of the following:
- Dofetilide because risk of severe heart problems may be increased by Trimethoprim (Carmurit T)
- Methotrexate, phenytoin, or sulfones (eg, dapsone) because their actions and the risk of their side effects may be increased by Trimethoprim (Carmurit T)
- Cyclosporine because its effectiveness may be decreased and risk of liver side effects may be increased by Trimethoprim (Carmurit T)
This may not be a complete list of all interactions that may occur. Ask your health care provider if Trimethoprim (Carmurit T) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Trimethoprim (Carmurit T) precautions
General
Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) should be given with caution to patients with possible folate deficiency. Folates may be administered concomitantly without interfering with the antibacterial action of Trimethoprim (Carmurit T).
Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) should also be given with caution to patients with impaired renal or hepatic function.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Carcinogenesis
Long-term studies in animals to evaluate carcinogenic potential have not been conducted with Trimethoprim (Carmurit T).
Mutagenesis
Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) was demonstrated to be nonmutagenic in the Ames assay. In studies at two laboratories, no chromosomal damage was detected in cultured Chinese hamster ovary cells at concentrations approximately 500 times human plasma levels; at concentrations approximately 1000 times human plasma levels in these same cells, a low level of chromosomal damage was induced at one of the laboratories. No chromosomal abnormalities were observed in cultured human leukocytes at concentrations of Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) up to 20 times human steady-state plasma levels. No chromosomal effects were detected in peripheral lymphocytes of human subjects receiving 320 mg of Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) in combination with up to 1600 mg of sulfamethoxazole per day for as long as 112 weeks.
Impairment of Fertility
No adverse effects on fertility or general reproductive performance were observed in rats given Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) in oral dosages as high as 70 mg/kg/day for males and 14 mg/kg/day for females.
Pregnancy
Teratogenic Effects
Pregnancy Category C. Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) has been shown to be teratogenic in the rat when given in doses 40 times the human dose. In some rabbit studies, the overall increase in fetal loss (dead and resorbed and malformed conceptuses) was associated with doses six times the human therapeutic dose.
While there are no large, well-controlled studies on the use of Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) in pregnant women, Brumfitt and Pursell, Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor potassium concentrations and to monitor renal function by calculating creatinine clearance.
REFERENCES
3. Brumfitt W, Pursell R. Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) -sulfamethoxazole in the treatment of bacteriuria in women. J Infect Dis. 1973; 128 (suppl):S657-S663.
4. Lacey RW, Simpson MHC, Fawcett C, et al. Comparison of single-dose Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) with a five-day course for the treatment of urinary tract infections in the elderly. Age and Ageing 10: 179-185, 1981.
5. Ewer TC, Bailey RR, Gilchrist NL, et al. Comparative study of norfloxacin and Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) for the treatment of elderly patients with urinary tract infection. NZ Med J 101: 537-539, 1988.
6. Marinella MA. Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) (Trimethoprim (Carmurit T) tablet) tablet) -induced hyperkalemia: An analysis of reported cases. Gerontology 45: 209-212, 1999.
What happens if I miss a dose of Trimethoprim (Carmurit T)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DailyMed. "POLYMYXIN B SULFATE; TRIMETHOPRIM SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "phenazopyridine". http://www.drugbank.ca/drugs/DB01438 (accessed September 17, 2018).
- DrugBank. "trimethoprim". http://www.drugbank.ca/drugs/DB00440 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
