What happens if I overdose Cefuroxime AXETIL 250 MG TABLET?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include seizures.
Proper storage of Cefuroxime AXETIL 250 MG TABLET tablets:
Store Cefuroxime AXETIL 250 MG TABLET tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cefuroxime AXETIL 250 MG TABLET tablets out of the reach of children and away from pets.
Overdose of Cefuroxime AXETIL 250 MG TABLET in details
Tablet: Excessively large doses of all cephalosporins can cause cerebral irritation and may cause convulsions.
Injection: Overdosage of cephalosporin can lead to cerebral irritation and seizures. With seizure, Cefuroxime AXETIL 250 MG TABLET should be discontinued and appropriate anticonvulsive therapy administered. Serum levels of Cefuroxime AXETIL 250 MG TABLET can be reduced by haemodialysis or peritoneal dialysis.
What should I avoid while taking Cefuroxime AXETIL 250 MG TABLET?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Cefuroxime AXETIL 250 MG TABLET warnings
BEFORE THERAPY WITH Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) FOR INJECTION USP AND DEXTROSE INJECTION USP IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEPHALOSPORINS, PENICILLINS OR OTHER DRUGS. THIS PRODUCT SHOULD BE GIVEN CAUTIOUSLY TO PENICILLIN-SENSITIVE PATIENTS. ANTIBIOTICS SHOULD BE ADMINISTERED WITH CAUTION TO ANY PATIENT WHO HAS DEMONSTRATED SOME FORM OF ALLERGY, PARTICULARLY TO DRUGS. IF AN ALLERGIC REACTION TO Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) OCCURS, DISCONTINUE THE DRUG. SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE EPINEPHRINE AND OTHER EMERGENCY MEASURES.
Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) for Injection USP and Dextrose Injection USP, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.
C. difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated.
What should I discuss with my healthcare provider before taking Cefuroxime AXETIL 250 MG TABLET?
Do not take this medication if you are allergic to Cefuroxime AXETIL 250 MG TABLET, or to other cephalosporin antibiotics, such as:
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cefaclor (Raniclor);
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cefadroxil (Duricef);
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cefazolin (Ancef);
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cefdinir (Omnicef);
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cefditoren (Spectracef);
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cefpodoxime (Vantin);
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cefprozil (Cefzil);
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ceftibuten (Cedax);
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cephalexin (Keflex); or
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cephradine (Velosef).
Before taking Cefuroxime AXETIL 250 MG TABLET, tell your doctor if you are allergic to any drugs (especially penicillins), or if you have:
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kidney disease;
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liver disease;
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a history of intestinal problems, such as colitis;
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diabetes; or
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if you are malnourished.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take Cefuroxime AXETIL 250 MG TABLET.
The oral suspension (liquid) form of Cefuroxime AXETIL 250 MG TABLET may contain phenylalanine. Talk to your doctor before using this form of Cefuroxime AXETIL 250 MG TABLET if you have phenylketonuria (PKU).
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Cefuroxime AXETIL 250 MG TABLET can make birth control pills less effective, which may result in pregnancy. Tell your doctor if you are taking birth control pills to prevent pregnancy. You may need to use another form of birth control during treatment with Cefuroxime AXETIL 250 MG TABLET.
Cefuroxime AXETIL 250 MG TABLET can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Cefuroxime AXETIL 250 MG TABLET precautions
General
Although Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) for Injection USP and Dextrose Injection USP rarely produces alterations in kidney function, evaluation of renal status during therapy is recommended, especially in seriously ill patients receiving the maximum doses. Cephalosporins should be given with caution to patients receiving concurrent treatment with potent diuretics as these regimens are suspected of adversely affecting renal function.
The total daily dose of Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) should be reduced in patients with transient or persistent renal insufficiency, because high and prolonged serum antibiotic concentrations can occur in such individuals from usual doses.
As with other antibiotics, prolonged use of Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) may result in overgrowth of nonsusceptible organisms. Careful observation of the patient is essential. If superinfection occurs during therapy, appropriate measures should be taken.
Broad-spectrum antibiotics should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.
Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins.
As with other therapeutic regimens used in the treatment of meningitis, mild-to-moderate hearing loss has been reported in a few pediatric patients treated with Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection). Persistence of positive CSF (cerebrospinal fluid) cultures at 18 to 36 hours has also been noted with Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) injection, as well as with other antibiotic therapies; however, the clinical relevance of this is unknown.
Cephalosporins may be associated with a fall in prothrombin activity. Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. Prothrombin time should be monitored in patients at risk and exogenous Vitamin K administered as indicated.
As with other dextrose-containing solutions, Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) for Injection USP and Dextrose Injection USP should be prescribed with caution in patients with overt or known subclinical diabetes mellitus or carbohydrate intolerance for any reason.
Prescribing Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) for Injection USP and Dextrose Injection USP in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Although lifetime studies in animals have not been performed to evaluate carcinogenic potential, no mutagenic activity was found for Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) in the mouse lymphoma assay and a battery of bacterial mutation tests. Positive results were obtained in an in vitro chromosome aberration assay, however, negative results were found in an in vivo micronucleus test at doses up to 10 g/kg. Reproduction studies in mice at doses up to 3,200 mg/kg/day (3.1 times the recommended maximum human dose based on mg/m²) have revealed no impairment of fertility.
Reproductive studies revealed no impairment of fertility in animals.
Pregnancy
Teratogenic Effects - Pregnancy Category B.
Reproduction studies have been performed in mice at doses up to 6,400 mg/kg/day (6.3 times the recommended maximum human dose based on mg/m²), and rabbits at doses up to 400 mg/kg/day (2.1 times the recommended maximum human dose based on mg/m²) and have revealed no evidence of impaired fertility or harm to the fetus due to Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection). There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Nursing Mothers
Since Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) is excreted in human milk, caution should be exercised when Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) is administered to a nursing woman.
Pediatric Use
Safety and effectiveness in pediatric patients below 3 months of age have not been established. Accumulation of other members of the cephalosporin class in newborn infants (with resulting prolongation of drug half-life) has been reported.
Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) for Injection USP and Dextrose Injection USP in the DUPLEX® Container is designed to deliver a 750 mg or 1.5 g dose of Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection). To prevent unintentional overdose, this product should not be used in pediatric patients who require less than the full adult dose of Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection).
Geriatric Use
Of the 1,914 subjects who received Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection) in 24 clinical studies of Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET (Cefuroxime AXETIL 250 MG TABLET injection) injection), 901 (47%) were 65 and over while 421 (22%) were 75 and over. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater susceptibility of some older individuals to drug effects cannot be ruled out. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
What happens if I miss a dose of Cefuroxime AXETIL 250 MG TABLET?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Call your doctor for instructions if you miss a Cefuroxime AXETIL 250 MG TABLET injection.
References
- DrugBank. "cefuroxime". http://www.drugbank.ca/drugs/DB01112 (accessed September 17, 2018).
- MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
