Cetoconazol Generis Dosage

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Dosage of Cetoconazol Generis in details

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Cetoconazol Generis Dosage

Generic name: Cetoconazol Generis 200mg

Dosage form: tablet

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

There should be laboratory as well as clinical documentation of infection prior to starting Cetoconazol Generis therapy. The usual duration of therapy for systemic infection is 6 months. Treatment should be continued until active fungal infection has subsided.

Adults

The recommended starting dose of Cetoconazol Generis® (Cetoconazol Generis) Tablets is a single daily administration of 200 mg (one tablet). If clinical responsiveness is insufficient within the expected time, the dose of Cetoconazol Generis® Tablets may be increased to 400 mg (two tablets) once daily.

Children

In small numbers of children over 2 years of age, a single daily dose of 3.3 to 6.6 mg/kg has been used. Cetoconazol Generis® Tablets have not been studied in children under 2 years of age.

More about Cetoconazol Generis (Cetoconazol Generis)

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What other drugs will affect Cetoconazol Generis?

Many drugs can interact with Cetoconazol Generis. Below is just a partial list. Tell your doctor if you are using:

This list is not complete and there are many other drugs that can interact with Cetoconazol Generis. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Cetoconazol Generis interactions

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Drugs that affect the absorption, distribution, metabolism, and excretion of Cetoconazol Generis may alter the plasma concentrations of Cetoconazol Generis. For example, gastric acid suppressants (e.g., antacids, histamine H2-blockers, proton pump inhibitors) have been shown to reduce plasma concentrations of Cetoconazol Generis.

Cetoconazol Generis is a substrate and potent inhibitor of CYP3A4. Therefore, the following drug interactions may occur when Cetoconazol Generis® is co-administered with other drugs that interact with CYP3A4.

  1. Cetoconazol Generis® may decrease the elimination of drugs metabolized by CYP3A4, thereby increasing their plasma concentrations. Increased exposure to these drugs may cause an increase or prolongation of their therapeutic and/or adverse effects. Concomitant use with Cetoconazol Generis® Tablets is contraindicated for drugs known to present a risk of serious side effects with increased exposure. For others, monitoring of plasma concentrations is advised when possible. Clinical signs and symptoms associated with these drugs should be monitored, with dosage adjusted as needed.
  2. Inducers of CYP3A4 may decrease the plasma concentrations of Cetoconazol Generis. Cetoconazol Generis® may not be effective in patients concomitantly taking one of these drugs. Therefore, administration of these drugs with Cetoconazol Generis® is not recommended.
  3. Other inhibitors of CYP3A4 may increase the plasma concentrations of Cetoconazol Generis. Patients who must take Cetoconazol Generis® concomitantly with one of these drugs should be monitored closely for signs or symptoms of increased or prolonged pharmacologic effects of Cetoconazol Generis®.

Table 1: Selected Drugs That Have Been Shown To or Are Predicted To Have Their Plasma Concentrations Altered By Cetoconazol Generis®*

Systemic exposure to these drugs is increased significantly by the addition of Cetoconazol Generis: Concomitant use with Cetoconazol Generis is contraindicated.
Alprazolam, midazolam, triazolam HMG-CoA reductase inhibitors (lovastatin, simvastatin)
Cisapride Nisoldipine
Dofetilide Pimozide
Eplerenone Quinidine
Ergot alkaloids (ergotamine, dihydroergotamine)
Systemic exposure to these drugs is increased by Cetoconazol Generis: Careful monitoring, with possible adjustment in dosage, is recommended.
Alfentanil, fentanyl, sulfentanil Indinavir, saquinavir
Amlodipine, felodipine, nicardipine, nifedipine Methylprednisolone
Bosentan Rifabutin
Buspirone Sildenafil
Busulfan Sirolimus (co-administration not recommended)
Carbamazepine Tacrolimus
Cilostazol Telithromycin
Cyclosporine Tolterodine
Digoxin Trimetrexate
Docetaxel, paclitaxel Verapamil

Oral anti-coagulants

Vinca alkaloids (vincristine, - vinblastine, vinorelbine)
* This list is not all-inclusive.

Table 2: Selected Drugs That Have Been Shown To or Are Predicted To Alter The Plasma Concentration Of Cetoconazol Generis®

Systemic exposure to Cetoconazol Generis is reduced significantly by these drugs: Concomitant use with Cetoconazol Generis is not recommended.
Carbamazepine Phenytoin
Gastric Acid Suppressants (antacids, antimuscarinics, histamine H2-blockers, proton pump inhibitors, sucralfate) Rifampin, rifabutin, isoniazid
Nevirapine
Systemic exposure to Cetoconazol Generis is increased significantly by this drug: Dose reduction of Cetoconazol Generis should be considered
Ritonavir
* This list is not all-inclusive.

Effects of Cetoconazol Generis on other drugs

Systemic exposure to the following drugs is significantly increased by co


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References

  1. DailyMed. "KETOCONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. FDA/SPL Indexing Data. "2DJ8R0NT7K: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  3. MeSH. "14-alpha Demethylase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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The results of a survey conducted on ndrugs.com for Cetoconazol Generis are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cetoconazol Generis. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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