Actions of Chemists own diarrhoea relief in details
Chemists own diarrhoea relief is an inhibitor of H+ K+ ATPase. This medication inhibits the activity of H+-K+-ATPase in gastric parietal cells and thus blocks the final stage of hydrochloric acid secretion. This leads to a reduction in basal and stimulated secretion, regardless of the nature of the stimulus. Due to the reduction of acid secretion omeprazole reduces or normalizes the effects of acid in the esophagus in patients with reflux esophagitis.
Chemists own diarrhoea relief has a bactericidal effect on Helicobacter pylori. Eradication of H. pylori when omeprazole used with antibiotics allows to quickly arrest the symptoms, to take a high degree of healing of damaged mucosa and persistent long-term remission and reduce the likelihood of bleeding from the gastrointestinal tract.
How should I take Chemists own diarrhoea relief?
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Take Chemists own diarrhoea relief with a full glass of water. Drink extra water while you are taking this medication to keep from getting dehydrated.
Chemists own diarrhoea relief is usually taken at the first sign of diarrhea, and again if diarrhea comes back. The first dose of Chemists own diarrhoea relief is usually twice as much as the following doses. Do not take this medication more than 3 times in 24 hours without your doctor's advice.
The Chemists own diarrhoea relief chewable tablet must be chewed before swallowing.
Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.
Immodium A-D Liquid and New Immodium A-D Liquid contain two different strengths of Chemists own diarrhoea relief. If you switch from using one brand to using the other, follow the dosing instructions carefully. Immodium A-D Liquid also contains a small amount of alcohol, but New Immodium A-D Liquid does not.
It may take up to 48 hours before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 10 days of treatment.
Store at room temperature away from moisture and heat. Do not freeze liquid Chemists own diarrhoea relief.
Chemists own diarrhoea relief administration
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Take Chemists own diarrhoea relief with a full glass of water. Drink extra water while you are taking this medication to keep from getting dehydrated.
Chemists own diarrhoea relief is usually taken at the first sign of diarrhea, and again if diarrhea comes back. The first dose of Chemists own diarrhoea relief is usually twice as much as the following doses. Do not take this medication more than 3 times in 24 hours without your doctor's advice.
The Chemists own diarrhoea relief chewable tablet must be chewed before swallowing.
Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.
Immodium A-D Liquid and New Immodium A-D Liquid contain two different strengths of Chemists own diarrhoea relief. If you switch from using one brand to using the other, follow the dosing instructions carefully. Immodium A-D Liquid also contains a small amount of alcohol, but New Immodium A-D Liquid does not.
It may take up to 48 hours before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 10 days of treatment.
Store at room temperature away from moisture and heat. Do not freeze liquid Chemists own diarrhoea relief.
Chemists own diarrhoea relief pharmacology
In vitro and animal studies show that Chemists own diarrhoea relief acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Chemists own diarrhoea relief binds to the opiate receptor in the gut wall. Consequently, it inhibits the release of acetylcholine and prostaglandins, thereby reducing peristalsis, and increasing intestinal transit time. Chemists own diarrhoea relief increases the tone of the anal sphincter, thereby reducing incontinence and urgency.
In man, Chemists own diarrhoea relief prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Clinical studies have indicated that the apparent elimination half-life of Chemists own diarrhoea relief in man is 10.8 hours with a range of 9.1 to 14.4 hours. Plasma levels of unchanged drug remain below 2 nanograms per mL after the intake of a 2 mg Chemists own diarrhoea relief capsule. Plasma levels are highest approximately five hours after administration of the capsule and 2.5 hours after the liquid. The peak plasma levels of Chemists own diarrhoea relief were similar for both formulations. Elimination of Chemists own diarrhoea relief mainly occurs by oxidative N-demethylation. Cytochrome P450 (CYP450) isozymes, CYP2C8 and CYP3A4, are thought to play an important role in Chemists own diarrhoea relief N-demethylation process since quercetin (CYP2C8 inhibitor) and ketoconazole (CYP3A4 inhibitor) significantly inhibited the N-demethylation process in vitro by 40% and 90%, respectively. In addition, CYP2B6 and CYP2D6 appear to play a minor role in Chemists own diarrhoea relief N-demethylation. Excretion of the unchanged Chemists own diarrhoea relief and its metabolites mainly occurs through the feces. In those patients in whom biochemical and hematological parameters were monitored during clinical trials, no trends toward abnormality during Chemists own diarrhoea relief therapy were noted. Similarly, urinalyses, EKG and clinical ophthalmological examinations did not show trends toward abnormality.
References
- NCIt. "Loperamide: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Loperamide: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
