Actions of Chlorhexidine Gluconate topical in details
Chlorhexidine Gluconate topical gluconate belongs to a class of medication called as antiseptic. It acts by killing as well as preventing bacterial growth. It kills bacteria by interacting with its cell surface. Dosage
How should I take Chlorhexidine Gluconate topical?
Chlorhexidine Gluconate topical oral rinse should be used after you have brushed and flossed your teeth. Rinse the toothpaste completely from your mouth with water before using the oral rinse. Do not eat or drink for several hours after using the oral rinse.
The cap on the original container of Chlorhexidine Gluconate topical can be used to measure the 15 mL (½ fluid ounce) dose of Chlorhexidine Gluconate topical. Fill the cap to the ``fill line.'' If you do not receive the dental rinse in its original container, make sure you have a measuring device to measure out the correct dose. Your pharmacist can help you with this.
Swish Chlorhexidine Gluconate topical around in the mouth for 30 seconds. Then spit out. Use the medicine full strength. Do not mix with water before using. Do not swallow the medicine.
Dosing
The dose of Chlorhexidine Gluconate topical will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Chlorhexidine Gluconate topical. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral rinse dosage form:
- For gingivitis:
- Adults—Use 15 milliliters (mL) as a mouth wash for 30 seconds two times a day.
- Children up to 18 years of age—Use and dose must be determined by your dentist or medical doctor.
- For gingivitis:
Missed Dose
If you miss a dose of Chlorhexidine Gluconate topical, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Chlorhexidine Gluconate topical administration
Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Rinse your mouth with Chlorhexidine Gluconate topical gluconate twice daily after brushing your teeth.
Measure your dose using the cup provided with the medication. Swish the medicine in your mouth for at least 30 seconds, then spit it out. Do not swallow the mouthwash.
Do not add water to the oral rinse. Do not rinse your mouth with water or other mouthwashes right after using Chlorhexidine Gluconate topical gluconate.
Chlorhexidine Gluconate topical gluconate may leave an unpleasant taste in your mouth. Do not rinse your mouth to remove this taste after using the medication. You may rinse the medicine away and reduce its effectiveness.
Use this medication for the full prescribed length of time. Your symptoms may improve before your gingivitis is completely cleared. Chlorhexidine Gluconate topical gluconate will not treat a viral or fungal infection such as cold sores, canker sores, or oral thrush (yeast infection).
Visit your dentist at least every 6 months for preventive tooth and gum care.
Store Chlorhexidine Gluconate topical gluconate at room temperature away from moisture and heat.
Chlorhexidine Gluconate topical pharmacology
Chlorhexidine Gluconate topical gluconate oral rinse provides antimicrobial activity during oral rinsing. The clinical significance of Chlorhexidine Gluconate topical gluconate oral rinse’s antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general reduction of counts of certain assayed bacteria, both aerobic and anaerobic, ranging from 54–97% through six months use.
Use of Chlorhexidine Gluconate topical gluconate oral rinse in a six month clinical study did not result in any significant changes in bacterial resistance, overgrowth of potentially opportunistic organisms or other adverse changes in the oral microbial ecosystem. Three months after Chlorhexidine Gluconate topical gluconate oral rinse use was discontinued, the number of bacteria in plaque had returned to baseline levels and resistance of plaque bacteria to Chlorhexidine Gluconate topical gluconate was equal to that at baseline.
Pharmacokinetics: Pharmacokinetic studies with Chlorhexidine Gluconate topical gluconate oral rinse indicate approximately 30% of the active ingredient, Chlorhexidine Gluconate topical gluconate, is retained in the oral cavity following rinsing. This retained drug is slowly released into the oral fluids. Studies conducted on human subjects and animals demonstrate Chlorhexidine Gluconate topical gluconate is poorly absorbed from the gastrointestinal tract. The mean plasma level of Chlorhexidine Gluconate topical gluconate reached a peak of 0.206 µg/g in humans 30 minutes after they ingested a 300-mg dose of the drug. Detectable levels of Chlorhexidine Gluconate topical gluconate were not present in the plasma of these subjects 12 hours after the compound was administered. Excretion of Chlorhexidine Gluconate topical gluconate occurred primarily through the feces (~90%). Less than 1% of the Chlorhexidine Gluconate topical gluconate ingested by these subjects was excreted in the urine.
References
- DailyMed. "CHLORHEXIDINE GLUCONATE; ISOPROPYL ALCOHOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- NCIt. "Chlorhexidine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Chlorhexidine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Chlorhexidine Gluconate topical are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Chlorhexidine Gluconate topical. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
