What happens if I overdose Cipra Pro?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.
Proper storage of Cipra Pro solution:
Store Cipra Pro solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cipra Pro solution out of the reach of children and away from pets.
Overdose of Cipra Pro in details
There have been 3 reports of Cipra Pro overdose including doses of up to 600 mg. All the 3 patients recovered and no symptoms associated with the overdoses were reported. Also in clinical trials of racemic citalopram, there were no reports of fatal citalopram overdose involving overdoses of up to 2000 mg.
Symptoms of overdose with racemic citalopram are dizziness, tremor, agitation, somnolence, unconsciousness, seizures, tachycardia, changes in the ECG with ST-T changes, broadening of the QRS complex, prolonged QT interval, arrhythmias, respiratory depression, sweating, nausea, tremor, amnesia, confusion, coma, hyperventilation, cyanosis, vomiting, rhabdomyolysis, metabolic acidosis, hypokalaemia. It is anticipated that overdoses with Cipra Pro would result in similar symptoms.
There is no specific antidote. Gastric lavage should be carried out as soon as possible after oral ingestion. Establish and maintain an airway, ensure adequate oxygenation and respiratory function. Cardiac and vital signs monitoring are recommended along with general symptomatic supportive measures.
What should I avoid while taking Cipra Pro?
Avoid taking tryptophan while you are taking Cipra Pro.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with Cipra Pro may cause you to bruise or bleed easily.
Drinking alcohol can increase certain side effects of Cipra Pro.
Cipra Pro may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Cipra Pro warnings
With caution Cipra Pro Elder Pharmaceuticals should be used in patients with renal insufficiency (creatinine clearance below 30 ml / min), hypomania, mania, pharmacologically uncontrolled epilepsy, depression with suicide attempts, diabetes, in elderly patients, with cirrhosis of the liver, the tendency to bleeding, simultaneously with the admission of drugs that lower the threshold of convulsive readiness, causing hyponatremia, with alcohol, with drugs metabolized with the participation of isoenzymes CYP2C19.
Cipra Pro should be prescribed only after 2 weeks after discontinuation of irreversible MAO inhibitors, and 24 h after cessation of treatment reversible inhibitor of MAO.
Non-selective MAO inhibitors may be prescribed no earlier than 7 days after discontinuation of this medication.
Cipra Pro Elder Pharmaceuticals should be abolished in the case of epileptic seizures or quickening in pharmacologically uncontrolled epilepsy.
With the development of manic this drug should be abolished.
Cipra Pro can increase the concentration of glucose in diabetes, which may require dose adjustment of hypoglycemic medications.
With the development of serotonin syndrome this medicine should be immediately withdrawn and a symptomatic therapy prescribed.
During the treatment, patients should avoid driving vehicles and other activities that require high concentration and speed of psychomotor reactions.
What should I discuss with my healthcare provider before taking Cipra Pro?
It is dangerous to try and purchase Cipra Pro on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of Cipra Pro purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit www.fda.gov/buyonlineguide.
You should not use this medicine if you are allergic to Cipra Pro or citalopram (Celexa), or if:
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you also take pimozide; or
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you are being treated with methylene blue injection.
Do not use Cipra Pro if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking Cipra Pro, you must wait at least 14 days before you start taking an MAOI.
To make sure Cipra Pro is safe for you, tell your doctor if you have:
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liver or kidney disease;
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seizures or epilepsy;
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diabetes;
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narrow-angle glaucoma;
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heart disease;
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bipolar disorder (manic depression); or
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a history of drug abuse or suicidal thoughts.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Cipra Pro. Your family or other caregivers should also be alert to changes in your mood or symptoms.
FDA pregnancy category C. Taking an SSRI antidepressant during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant while taking Cipra Pro. Do not start or stop taking this medicine during pregnancy without your doctor's advice.
Cipra Pro can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Cipra Pro should not be given to a child younger than 12 years old.
Cipra Pro precautions
Several cases of hyponatremia and SIADH (syndrome of inappropriate antidiuretic hormone secretion) have been reported in association with Cipra Pro treatment. All patients with these events have recovered with discontinuation of Cipra Pro and/or medical intervention. Cipra Pro should be used cautiously in patients with a history of mania and seizure disorder. The possibility of a suicide attempt is inherent in depression and may persist until significant remission occurs. Prescriptions for Cipra Pro should be written for the smallest quantity of tablets consistent with good patient management, in order to reduce the risk of overdose. Caution is advisable in using Cipra Pro in patients with diseases or conditions that produce altered metabolism or hemodynamic responses.
Use in pregnancy & lactation: In animal reproduction studies, Cipra Pro has been shown to have adverse effects on embryo/fetal and postnatal development, including teratogenic effects, when administered at doses greater than human therapeutic doses. There are no adequate and well-controlled studies in pregnant women; therefore, Cipra Pro should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
It is expected that Cipra Pro will be excreted into human milk. Consequently, breastfeeding is not recommended during treatment.
What happens if I miss a dose of Cipra Pro?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DrugBank. "Escitalopram". http://www.drugbank.ca/drugs/DB01175 (accessed September 17, 2018).
- MeSH. "Antidepressive Agents, Second-Generation". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- FDA Medication Guides. "Lexapro: FDA Medication Guides are paper handouts that come with many prescription medicines. The guides address issues that are specific to particular drugs and drug classes, and they contain FDA-approved information that can help patients avoid serious adverse events. ". https://www.accessdata.fda.gov/drugs... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
