Clavulanate K/clavulanic acid/Co-amoxiclav Side effects

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Consists of clavulanate K, clavulanic acid, Co-amoxiclav

Side effects of Clavulanic acid in details

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Hypersensitivity reactions, GI disturbances, pseudomembranous colitis, blood dyscrasias, transient increase in liver enzymes, hepatitis, cholestatic jaundice, giddiness, neuromuscular hyperirritability, seizures, electrolyte disturbances, decreased serum uric acid concentration, increased serum creatinine and/or BUN concentrations. Thrombophlebitis and local reactions at the IV infusion site. Haemorrhagic cystitis especially in cystic fibrosis patients.

Potentially Fatal: Anaphylaxis.

Clavulanic acid contraindications

Hypersensitivity to penicillins.

Side effects of Co-amoxiclav in details

Diarrhea; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation; yellowing of the skin or eyes.

Co-amoxiclav contraindications

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in patients with a history of allergic reactions to any penicillin. It is also contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with Co-amoxiclav.

References

  1. European Chemicals Agency - ECHA. "clavulanic acid: The European Chemicals Agency (ECHA) is an agency of the European Union which is the driving force among regulatory authorities in implementing the EU's groundbreaking chemicals legislation for the benefit of human health and the environment as well as for innovation and competitiveness.". https://echa.europa.eu/ (accessed September 17, 2018).
  2. NCIt. "Clavulanic Acid: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  3. NIST. "Clavulanic acid". http://www.nist.gov/srd/nist1a.cfm (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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