Clavulanic Acid Uses

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Clavulanic Acid indications

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Upper & lower resp tract, urinary tract, skin & soft tissue infections.

Uses of Clavulanic Acid in details

Clavulanic Acid is used to increase the effect of certain antibiotics (amoxicillin) to treat bacterial infections of the respiratory tract (bronchitis, pneumonia), urinary tract, ear, nose, sinus and throat, skin and soft tissues, bone and joints, and to prevent infections after surgery.

Clavulanic Acid dosage

Tab Adult & childn >12 yr 375-625 mg tid. Severe infections One 1,000-mg tab bid. 156 mg/5 mL syr Childn >6 yr 2 tsp, 1-6 yr 1 tsp. 312 mg/5 mL syr Childn >6 yr 1 tsp, 1-6 yr ½ tsp. To be given tid.

Clavulanic Acid interactions

Probenecid decreases clearance of ticarcillin. Increased bleeding risk with warfarin, acenocoumarol. Possible increase in ciclosporin, methotrexate levels with concurrent use. Possible contraceptive failure with combined oral contraceptives.

Clavulanic Acid side effects

Hypersensitivity reactions, GI disturbances, pseudomembranous colitis, blood dyscrasias, transient increase in liver enzymes, hepatitis, cholestatic jaundice, giddiness, neuromuscular hyperirritability, seizures, electrolyte disturbances, decreased serum uric acid concentration, increased serum creatinine and/or BUN concentrations. Thrombophlebitis and local reactions at the IV infusion site. Haemorrhagic cystitis especially in cystic fibrosis patients.

Potentially Fatal: Anaphylaxis.

Clavulanic Acid contraindications

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Hypersensitivity to penicillins.

Active ingredient matches for Clavulanic Acid:

Clavulanic Acid


List of Clavulanic Acid substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Clavter LB Forte Syrup (Dexter Laboratories Pvt. Ltd.)$ 1.86
Climex 500+125 Tablet (Finesse Pharmaceuticals)$ 0.46
Cliver A 30 ml Syrup (Adley Formulation)$ 0.15
Codimol CV 100+62.5 Tablet (Gujarat Terce Laboratories Ltd.)$ 0.16
Codimol CV 200+125 Tablet (Gujarat Terce Laboratories Ltd.)$ 0.29
CODIMOL CV 100MG/62.5MG TABLET 1 strip / 10 tablets each (Gujarat Terce Laboratories Ltd.)$ 0.87
CODIMOL CV 200MG/125MG TABLET 1 strip / 10 tablets each (Gujarat Terce Laboratories Ltd.)$ 1.59
CODIMOL CV 50MG/31.25MG DRY SYRUP 1 bottle / 30 ml dry syrup each (Gujarat Terce Laboratories Ltd.)$ 0.82
Codimol CV 100 mg/62.5 mg Tablet (Gujarat Terce Laboratories Ltd.)$ 0.09
Codimol CV 200 mg/125 mg Tablet (Gujarat Terce Laboratories Ltd.)$ 0.16
Codimol CV 50 mg/31.25 mg Dry Syrup (Gujarat Terce Laboratories Ltd.)$ 0.82
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Cumin CV 200+125 Tablet (D.R. Johns Labs)$ 0.36
CUMIN CV 200 MG/125 MG TABLET 1 strip / 10 tablets each (D.R. Johns Labs)$ 3.98
Cumin CV 200 mg/125 mg Tablet (D.R. Johns Labs)$ 0.40
Demoxin CB 500+125 Tablet (Alde Medi Impex Ltd.)$ 0.22
Dewmox CV 1000+200 Injection (Haledew Remedies)$ 2.16
Dewmox CV 500+125 Tablet (Haledew Remedies)$ 0.30
Dewmox CV 30 ml Syrup (Haledew Remedies)$ 0.12
Dilomox CV 30 ml Syrup (Floreat Medica Pvt. Ltd.)$ 0.11
Diluted 62.5 mg Tablet (Aristo Pharmaceuticals Pvt Ltd.)$ 0.30
Doxi Pro Plus 200+125 Tablet (Unisolve Pharmaceuticals Pvt Ltd)$ 0.29
Doxiclav Tablet (Canon Biotech)$ 0.54
Doxicure CV 200+125 Tablet (Balsons Pharmaceuticals (Best Cure Pharma))$ 0.47
Doxmin CC 200+125 Tablet (Welkind Pharma)$ 0.38
Doxmin CC 100+62.5 Tablet (Welkind Pharma)$ 0.24
Figthox Inj 1000+200 Injection (Piramal Healthcare)$ 1.59
Forcef CV 250+62.5 Tablet (Aristo Pharmaceuticals Pvt Ltd.)$ 0.30
Forcef CV 500+125 Tablet (Aristo Pharmaceuticals Pvt Ltd.)$ 0.59
FORCEF CV 250 MG/125 MG TABLET 1 strip / 6 tablets each (Aristo Pharmaceuticals Pvt Ltd.)$ 2.15
FORCEF CV 500 MG/125 MG TABLET 1 strip / 6 tablets each (Aristo Pharmaceuticals Pvt Ltd.)$ 4.22
Forcef CV 250 mg/125 mg Tablet (Aristo Pharmaceuticals Pvt Ltd.)$ 0.39
Forcef CV 500 mg/125 mg Tablet (Aristo Pharmaceuticals Pvt Ltd.)$ 0.73
Gudcef CV 200+125 Tablet (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.24
Gudcef CV 30 ml Syrup (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.12
Gudcef CV 100+62.5 Tablet (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.14
GUDCEF CV 100MG TABLET 1 strip / 10 tablets each (Mankind Pharmaceuticals Pvt. Ltd.)$ 1.57
GUDCEF CV 200 MG/125 MG TABLET 1 strip / 10 tablets each (Mankind Pharmaceuticals Pvt. Ltd.)$ 2.89
GUDCEF CV 50 MG/31.25 MG DRY SYRUP 1 bottle / 30 ML dry syrup each (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.84
Indclav LB 875+125+LB Tablet (Ind-Chemie Health Specialities Pvt Ltd.)$ 0.33
Indclav LB 250+125+LB Tablet (Ind-Chemie Health Specialities Pvt Ltd.)$ 0.20
Indclav LB 500+125+LB Tablet (Ind-Chemie Health Specialities Pvt Ltd.)$ 0.22
INDCLAV LB TABLET 1 strip / 10 tablets each (Ind-Chemie Health Specialities Pvt Ltd.)$ 2.22

References

  1. PubChem. "CLAVULANIC ACID". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "CLAVULANIC ACID". http://www.drugbank.ca/drugs/DB00766 (accessed September 17, 2018).
  3. MeSH. "beta-Lactamase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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