What are the possible side effects of Coup O.e.?
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Loss of appetite; nausea; sensitivity to sunlight; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; chest pain; dark urine; decreased urination; fever, chills, or sore throat; moderate to severe sunburn; red, swollen, blistered, or peeling skin; severe diarrhea; severe or persistent headache; stomach pain or cramps; throat irritation; trouble swallowing; unusual bruising or bleeding; unusual joint pain; unusual tiredness; vaginal irritation or discharge; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the.
Side effects of Coup O.e. in details
Clinical Trial Experience
The safety and efficacy of Coup O.e. delayed-release tablets, 200 mg as a single daily dose was evaluated in a multicenter, randomized, double-blind, active-controlled study. Coup O.e. delayed-release tablets, 200 mg was given orally once-a-day for 7 days and compared to Coup O.e. capsules 100 mg given orally twice daily for 7 days for the treatment of men and women with uncomplicated urogenital C. trachomatis infection.
Adverse events in the Safety Population were reported by 99 (40.2%) subjects in the Coup O.e. delayed-release tablets, 200 mg treatment group and 132 (53.2%) subjects in the Coup O.e. capsules reference treatment group. Most AEs were mild in intensity. The most commonly reported adverse events in both treatment groups were nausea, vomiting, diarrhea, and bacterial vaginitis, Table 1.
| Coup O.e. delayed-release tablets, 200 mg N = 246 | |
|---|---|
| Preferred Term | n (%) |
| Subjects with any AE | 99 (40.2) |
| Nausea | 33 (13.4) |
| Vomiting | 20 (8.1) |
| Headache | 5 (2.0) |
| Diarrhea | 8 (3.3) |
| Abdominal Pain Upper | 5 (2.0) |
| Vaginitis Bacterial | 8 (3.3) |
| Vulvovaginal Mycotic Infection | 5 (2.0) |
Because clinical trials are conducted under prescribed conditions, adverse reaction rates observed in the clinical trial may not always reflect the rates observed in practice.
Postmarketing Experience
The following adverse reactions have been identified during post-approval use of doxycycline. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate a causal relationship to drug exposure.
Due to oral doxycycline's virtually complete absorption, side effects to the lower bowel, particularly diarrhea, have been infrequent. The following adverse reactions have been observed in patients receiving tetracyclines:
Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region. Hepatotoxicity has been reported. These reactions have been caused by both the oral and parenteral administration of tetracyclines. Esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of drugs in the tetracycline- class. Most of these patients took medications immediately before going to bed.
Skin: Maculopapular and erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, and erythema multiforme have been reported. Photosensitivity is discussed above.
Renal: Rise in BUN has been reported and is apparently dose-related.
Hypersensitivity reactions: Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.
Blood: Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported.
Intracranial Hypertension: Intracranial hypertension (IH, pseudotumor cerebri) has been associated with the use of tetracycline
Thyroid Gland Changes: When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function are known to occur.
What is the most important information I should know about Coup O.e.?
- Be sure to use Coup O.e. delayed-release tablets for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Coup O.e. delayed-release tablets only works against bacteria; it does not treat viral infections (eg, the common cold).
- Long-term or repeated use of Coup O.e. delayed-release tablets may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- If you are taking Coup O.e. delayed-release tablets to prevent malaria, please note that no malaria medicine, including Coup O.e. delayed-release tablets, guarantees protection against malaria. Stay in well-screened areas, use mosquito nets, cover the body with clothing, and use insect repellent to avoid being bitten by mosquitoes.
- Hormonal birth control (eg, birth control pills) may not work as well while you are using Coup O.e. delayed-release tablets. To prevent pregnancy, use an extra form of birth control (eg, condoms).
- Coup O.e. delayed-release tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Coup O.e. delayed-release tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or blood stools occur. Do not treat diarrhea without first checking with your doctor.
- Do not use more than the recommended dose or use Coup O.e. delayed-release tablets for longer than prescribed without checking with your doctor.
- Tell your doctor or dentist that you take Coup O.e. delayed-release tablets before you receive any medical or dental care, emergency care, or surgery.
- Coup O.e. delayed-release tablets may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Coup O.e. delayed-release tablets.
- Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Coup O.e. delayed-release tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Coup O.e. delayed-release tablets should not be used in CHILDREN younger than 8 years old; permanent yellow-gray-brown tooth discoloration may occur.
- PREGNANCY and BREAST-FEEDING: Coup O.e. delayed-release tablets has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Coup O.e. delayed-release tablets while you are pregnant. Coup O.e. delayed-release tablets is found in breast milk. Do not breast-feed while taking Coup O.e. delayed-release tablets.
Coup O.e. contraindications
Hypersensitivity to tetracyclines.
Use in pregnancy & lactation: Use is not recommended during the last half of pregnancy and nursing mother.
Use in children: Use in children <8 years is not recommended as tetracyclines may cause permanent discoloration of the teeth, enamel hypoplasia and inhibition of linear skeletal growth.
References
- DTP/NCI. "Procarbazine hydrochloride: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "procarbazine: The European Chemicals Agency (ECHA) is an agency of the European Union which is the driving force among regulatory authorities in implementing the EU's groundbreaking chemicals legislation for the benefit of human health and the environment as well as for innovation and competitiveness.". https://echa.europa.eu/ (accessed September 17, 2018).
- HSDB. "PROCARBAZINE". https://toxnet.nlm.nih.gov/cgi-bin/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Coup O.e. are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Coup O.e.. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported side effects
No survey data has been collected yetConsumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
