What are the possible side effects of Cyanocobalamin?
Get emergency medical help if you have any of these signs of an allergic reaction to Cyanocobalamin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have signs of low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling.
Common Cyanocobalamin side effects may include:
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runny nose, sneezing;
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stuffy nose, sinus pain, sore throat, cough with mucus;
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headache, dizziness;
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joint pain; or
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itching or rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Side effects of Cyanocobalamin in details
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
The data described below and in Table 1 reflect exposure in 25 subjects (age range 27-82 years; 17 women; 21 Caucasians) with vitamin B12 deficiency (12 with pernicious anemia, 4 secondary to gastrointestinal surgery, 9 with unknown cause) who received Cyanocobalamin 50 mcg daily for 8 weeks in an uncontrolled clinical trial. Prior to enrollment, all subjects were required to have normal vitamin B12 levels with intramuscular vitamin B12 injections. One patient who completed the study developed epistaxis on Day 12 of dosing and was noted to have irritation of the right nasal septum at study end. This patient had pre-existing allergic rhinitis and required a doubling of the Cyanocobalamin dose during the last week of the study because of declining vitamin B12 concentrations.
| Preferred Term | Cyanocobalamin (N=25)n (%) |
| Arthralgia | 3 (12%) |
| Dizziness | 3 (12%) |
| Headache | 3 (12%) |
| Nasopharyngitis | 3 (12%) |
| Rhinorrhea | 3 (12%) |
| Bronchitis | 2 (8%) |
| Nasal Discomfort | 2 (8%) |
| Pain | 2 (8%) |
| Rash | 2 (8%) |
| Asthma | 1 (4%) |
| Back Pain | 1 (4%) |
| Cough | 1 (4%) |
| Epistaxis | 1 (4%) |
| Hypersomnia | 1 (4%) |
| Influenza Like Illness | 1 (4%) |
| Malaise | 1 (4%) |
| Pharyngolaryngeal Pain | 1 (4%) |
| Postnasal Drip | 1 (4%) |
| Procedural Pain | 1 (4%) |
| Pyrexia | 1 (4%) |
| Scab | 1 (4%) |
| Sinus Headache | 1 (4%) |
| Sinusitis | 1 (4%) |
| Tooth Abscess | 1 (4%) |
Experience with
Parenteral Vitamin B12
The following adverse reactions have been reported with parenteral vitamin B12:
| Generalized: | Anaphylactic shock and death |
| Cardiovascular: | Pulmonary edema and congestive heart failure early in treatmentPeripheral vascular thrombosis |
| Hematological | Polycythemia vera |
| Gastrointestinal: | Mild transient diarrhea |
| Dermatological: | Itching; transitory exanthema |
Postmarketing Experience
The following adverse reactions have been identified during postapproval use of Cyanocobalamin. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Angioedema and angioedema-like reactions.
What is the most important information I should know about Cyanocobalamin?
- Heavy alcohol intake for more than 2 weeks may decrease the effectiveness of Cyanocobalamin (b12). Check with your doctor if you drink alcohol on a regular basis.
- Do not substitute folic acid for Cyanocobalamin (b12) without first checking with your doctor. Folic acid may prevent anemia but may not prevent other serious symptoms such as spinal cord problems.
- You should have blood tests every 3 to 6 months to monitor your progress.
- Certain medicines, including antibiotics, methotrexate, or pyrimethamine, may interfere with lab tests for vitamin B, and folic acid levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
- Cyanocobalamin (b12) contains benzyl alcohol, a preservative. Do not use Cyanocobalamin (b12) in NEWBORNS or INFANTS because serious and sometimes fatal nervous system problems and other side effects may occur.
- PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Cyanocobalamin (b12), discuss with your doctor the benefits and risks of using Cyanocobalamin (b12) during pregnancy. Cyanocobalamin (b12) is excreted in breast milk. If you are or will be breast-feeding while you are using Cyanocobalamin (b12), check with your doctor or pharmacist to discuss the risks to your baby.
Cyanocobalamin contraindications
You should not use this medication if you are allergic to cobalt, or if you have Leber's disease. Cyanocobalamin can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.
To treat pernicious anemia, you will have to use this medication on a regular basis for the rest of your life. Not using the medication can lead to irreversible nerve damage in your spinal cord.
Pernicious anemia is also treated with folic acid to help maintain red blood cells. However, folic acid will not treat Vitamin B12 deficiency and will not prevent possible damage to the spinal cord. Take all of your medications as directed.
Your dose needs may change if you become pregnant, if you breast-feed, or if you eat a vegetarian diet. Tell your doctor about any changes in your diet or medical condition.
Reviews
The results of a survey conducted on ndrugs.com for Cyanocobalamin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cyanocobalamin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported side effects
No survey data has been collected yetConsumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
