Actions of Cyclopam Injections in details
Cyclopam Injections relieves smooth muscle spasm of the gastrointestinal tract. Animal studies indicate that this action is achieved via a dual mechanism:
- a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites with approximately 1/8 the milligram potency of atropine (in vitro, guinea pig ileum); and
- a direct effect upon smooth muscle (musculotropic) as evidenced by Cyclopam Injections's antagonism of bradykinin- and histamine-induced spasms of the isolated guinea pig ileum.
Atropine did not affect responses to these two agonists. In vivo studies in cats and dogs showed Cyclopam Injections to be equally potent against acetylcholine (ACh)- or barium chloride (BaCl2)-induced intestinal spasm while atropine was at least 200 times more potent against effects of ACh than BaCl2. Tests for mydriatic effects in mice showed that Cyclopam Injections was approximately 1/500 as potent as atropine; antisialagogue tests in rabbits showed Cyclopam Injections to be 1/300 as potent as atropine.
How should I take Cyclopam Injections?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Cyclopam Injections oral is taken by mouth.
Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).
Cyclopam Injections injection is given in a muscle if you are unable to take the medicine by mouth.
Call your doctor if your symptoms do not improve after 2 weeks.
Store at room temperature away from moisture and heat.
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Cyclopam Injections administration
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Cyclopam Injections is usually taken 4 times each day. Your doctor may occasionally change your dose to make sure you get the best results.
Take this medicine with a full glass of water.
Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Talk with your doctor if your symptoms do not improve after 2 weeks of treatment.
Store at room temperature away from moisture and heat.
Cyclopam Injections pharmacology
Mechanism Of Action
Cyclopam Injections relieves smooth muscle spasm of the gastrointestinal tract. Animal studies indicate that this action is achieved via a dual mechanism:
- a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites with approximately 1/8 the milligram potency of atropine (in vitro, guinea pig ileum); and
- a direct effect upon smooth muscle (musculotropic) as evidenced by Cyclopam Injections's antagonism of bradykinin- and histamine-induced spasms of the isolated guinea pig ileum.
Atropine did not affect responses to these two agonists. In vivo studies in cats and dogs showed Cyclopam Injections to be equally potent against acetylcholine (ACh)- or barium chloride (BaCl. Tests for mydriatic effects in mice showed that Cyclopam Injections was approximately 1/500 as potent as atropine; antisialagogue tests in rabbits showed Cyclopam Injections to be 1/300 as potent as atropine.
Pharmacodynamics
Cyclopam Injections can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function.
Pharmacokinetics
Absorption And Distribution
In man, Cyclopam Injections is rapidly absorbed after oral administration, reaching peak values within 60-90 minutes. Mean volume of distribution for a 20 mg oral dose is approximately 3.65 L/kg suggesting exentsive distribution in tissues.
Elimination
The metabolism of Cyclopam Injections was not studied. The principal route of excretion is via the urine (79.5% of the dose). Excretion also occurs in the feces, but to a lesser extent (8.4%). Mean half-life of plasma elimination in one study was determined to be approximately 1.8 hours when plasma concentrations were measured for 9 hours after a single dose. In subsequent studies, plasma concentrations were followed for up to 24 hours after a single dose, showing a secondary phase of elimination with a somewhat longer half-life.
Clinical Studies
In controlled clinical trials involving over 100 patients who received drug, 82% of patients treated for functional bowel/irritable bowel syndrome with Cyclopam Injections hydrochloride at initial doses of 160 mg daily (40 mg four times daily) demonstrated a favorable clinical response compared with 55% treated with placebo (p<0.05).
References
- NCIt. "Dicyclomine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Dicyclomine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Cyclopam Injections are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cyclopam Injections. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
