Actions of Depamine in details
Depamine is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. From in vitro studies which indicate that one atom of copper combines with two molecules of Depamine. Depamine also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between Depamine and cystine, resulting in formation of Depamine-cysteine disulfide, a substance that is much more soluble than cystine and is excreted readily. Depamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. The mechanism of action of Depamine in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, Depamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, Depamine in vitro depresses T-cell activity but not B-cell activity.
How should I take Depamine?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take Depamine on an empty stomach, at least 1 hour before or 2 hours after a meal.
Drink plenty of liquids while you are taking Depamine.
Do not drink milk within 1 hour before or 1 hour after you take Depamine.
You will need frequent urine tests.
Your condition may seem to get worse for a short time when you first start taking this medicine. Do not change your doses or medication schedule without your doctor's advice. Every person taking Depamine should remain under the care of a doctor.
It may take up to 3 months before your rheumatoid arthritis symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
You may need to follow a special diet while using Depamine. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.
If you do stop taking Depamine for any reason, do not start taking it again until you talk to your doctor.
Your doctor may want you to take a multivitamin or take extra iron or vitamin B6 while you are taking Depamine. Take only the amount of supplements that your doctor has prescribed.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Depamine administration
Take Depamine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.
Depamine must be taken on an empty stomach, at least 1 hour before or 2 hours after a full meal, and at least 1 hour before or after any other drug, food, or milk. Taking Depamine with anything else in the stomach greatly decreases its effectiveness.
Do not stop taking Depamine without first talking to your doctor. Stopping therapy may cause your body to react abnormally when therapy is restarted. If you do stop taking the medication, do not restart without first talking to your doctor. You may need special monitoring.
Your doctor may want you to take a vitamin and mineral supplement during treatment with Depamine. Depamine may reduce vitamin B6 and iron in the body. Follow your doctor's instructions.
Store Depamine at room temperature away from moisture and heat.
Depamine pharmacology
Depamine is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. From in vitro studies which indicate that one atom of copper combines with two molecules of Depamine, it would appear that one gram of Depamine should be followed by the excretion of about 200 milligrams of copper; however, the actual amount excreted is about one percent of this.
Depamine also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between Depamine and cystine, resulting in formation of Depamine-cysteine disulfide, a substance that is much more soluble than cystine and is excreted readily.
Depamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed.
The mechanism of action of Depamine in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, Depamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, Depamine in vitro depresses T-cell activity but not B-cell activity.
In vitro, Depamine dissociates macroglobulins (rheumatoid factor) although the relationship of the activity to its effect in rheumatoid arthritis is not known.
In rheumatoid arthritis, the onset of therapeutic response to Depamine may not be seen for two or three months. In those patients who respond, however, the first evidence of suppression of symptoms such as pain, tenderness, and swelling is generally apparent within three months. The optimum duration of therapy has not been determined. If remissions occur, they may last from months to years, but usually require continued treatment.
In all patients receiving Depamine, it is important that Depamine be given on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour apart from any other drug, food, milk, antacid, zinc or iron-containing preparation. This permits maximum absorption and reduces the likelihood of inactivation by metal binding in the gastrointestinal tract.
Pharmacokinetics
Depamine is absorbed rapidly but incompletely (40-70%) from the gastrointestinal tract, with wide inter-individual variations. Food, antacids, and iron reduce absorption of the drug. The peak plasma concentration of Depamine occurs 1-3 hours after ingestion; it is approximately 1-2 mg/L after an oral dose of 250 mg. The drug appears in the plasma as free Depamine, Depamine disulfide, and cysteine-Depamine disulfide. When prolonged treatment is stopped, there is a slow elimination phase lasting 4-6 days.
More than 80% of plasma Depamine is bound to proteins, especially albumin and ceruloplasmin. The drug also binds to erythrocytes and macrophages. A small fraction of the dose is metabolized in the liver to S-methyl-D-Depamine. Excretion is mainly renal, mainly as disulfides.
Reviews
The results of a survey conducted on ndrugs.com for Depamine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Depamine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
