Actions of Dextromethorphan HBr in details
Dextromethorphan HBr is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Dextromethorphan HBr has not addiction effects and it has no analgesic and hypnotic action. Dextromethorphan HBr starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Dextromethorphan HBr is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Dextromethorphan HBr used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Dextromethorphan HBr has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.
How should I take Dextromethorphan HBr?
Use Dextromethorphan HBr exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Cough medicine is usually taken only for a short time until your symptoms clear up.
Do not give Dextromethorphan HBr to a child younger than 4 years old.
Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.
Measure the liquid form of Dextromethorphan HBr with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Allow the Dextromethorphan HBr lozenge or disintegrating strip to dissolve in your mouth.
Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.
If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cough medicine within the past few days.
Store Dextromethorphan HBr at room temperature, away from heat, light, and moisture.
Dextromethorphan HBr administration
Shake extended release suspension well before use. Only use dosing cup provided to measure liquid doses.
Dextromethorphan HBr pharmacology
After oral administration Dextromethorphan HBr is completely absorbed from the gastrointestinal tract. Cmax of Dextromethorphan HBr in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.
References
- DailyMed. "DEXTROMETHORPHAN HYDROBROMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- NCIt. "Dextromethorphan: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Dextromethorphan: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Dextromethorphan HBr are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dextromethorphan HBr. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported administration
When best can I take Dextromethorphan HBr, on an empty stomach, before or after food?ndrugs.com website users have also released a report stating that Dextromethorphan HBr should be taken After food. In any case, this may not be the right description on how you ought to take this Dextromethorphan HBr. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Dextromethorphan HBr can be taken.
| Users | % | ||
|---|---|---|---|
| After food | 1 | 100.0% | |
Consumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
