The usual adult oral dosage is 30 to 45 mL (2 to 3 tablespoonfuls, containing 20 g to 30 g of Dhactulose Solution) three or four times daily. The dosage may be adjusted every day or two to produce 2 or 3 soft stools daily.

Hourly doses of 30 to 45 mL of Dhactulose Solution may be used to induce the rapid laxation indicated in the initial phase of the therapy of portal-systemic encephalopathy. When the laxative effect has been achieved, the dose of Dhactulose Solution may then be reduced to the recommended daily dose. Improvement in the patient's condition may occur within 24 hours but may not begin before 48 hours or even later.

Continuous long-term therapy is indicated to lessen the severity and prevent the recurrence of portal-systemic encephalopathy. The dose of Dhactulose Solution for this purpose is the same as the recommended daily dose.

Pediatric

Very little information on the use of Dhactulose in pediatric patients has been recorded. As with adults, the subjective goal in proper treatment is to produce 2 to 3 soft stools daily. On the basis of information available, the recommended initial daily oral dose in infants is 2.5 to 10 mL in divided doses. For older pediatric patients, the total daily dose is 40 to 90 mL. If the initial dose causes diarrhea, the dose should be reduced immediately. If diarrhea persists, Dhactulose Solution should be discontinued.

Rectal

When the adult patient is in the impending coma or coma stage of portal-systemic encephalopathy and the danger of aspiration exists, or when the necessary endoscopic or intubation procedures physically interfere with the administration of the recommended oral doses, Dhactulose Solution may be given as a retention enema via a rectal balloon catheter. Cleansing enemas containing soapsuds or other alkaline agents should not be used.

Three hundred mL of Dhactulose Solution should be mixed with 700 mL of water or physiologic saline and retained for 30 to 60 minutes. Dhactulose Solution enema may be repeated every 4 to 6 hours. If the enema is inadvertently evacuated too promptly, it may be repeated immediately.

The goal of treatment is reversal of the coma stage in order that the patient may be able to take oral medication. Reversal of coma may take place within 2 hours of the first enema in some patients. Dhactulose Solution, given orally in the recommended doses, should be started before Dhactulose Solution by enema is stopped entirely.

More about Dhactulose (Dhactulose)

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Consumer resources

Dhactulose solution

Other brands: Enulose, Kristalose, Constulose

Professional resources

Dhactulose (FDA)
Dhactulose (AHFS Monograph)

Related treatment guides

Constipation, Chronic
Constipation, Acute
Hepatic Encephalopathy

What other drugs will affect Dhactulose?

There may be other drugs that can interact with Dhactulose. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Dhactulose interactions

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No laxative should be taken within 2 hrs of another medication because the desired effect of the other medication may be reduced.

Antacids: Antacids given concurrently with Dhactulose may inhibit the desired Dhactulose-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with Dhactulose.

Neomycin: In some situations, neomycin administered together with Dhactulose is more effective than either one alone.

Although, theoretically, the elimination of certain colonic bacteria by neomycin and possibly other anti-infective agents may interfere with the desired degradation of Dhactulose and thus prevent the acidification of colonic contents. There have been some reports that Dhactulose-fermenting bacteria are relatively resistant to neomycin, which may explain why a combination could work in some cases. The status of the Dhactulose-treated patients should be closely monitored in the event of concomitant oral antibiotic therapy.

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References

DailyMed. "LACTULOSE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
FDA/SPL Indexing Data. "9XH2P2N8EP: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
MeSH. "Gastrointestinal Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Dhactulose are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dhactulose. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

2 consumers reported frequency of use

How frequently do I need to take Dhactulose?
It was reported by ndrugs.com website users that Dhactulose should ideally be taken 3 times in a day as the most common frequency of the Dhactulose. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Dhactulose should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.

	Users		%
3 times in a day	2		100.0%

4 consumers reported doses

What doses of Dhactulose drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Dhactulose drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.

	Users	%
51-100mg	1	25.0%
201-500mg	1	25.0%
11-50mg	1	25.0%
6-10mg	1	25.0%

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Information checked by Dr. Sachin Kumar, MD Pharmacology

Dhactulose Dosage

Dosage of Dhactulose in details