Dialope Pregnancy

• Pregnancy of Dialope in details
• Dialope breastfeeding
• Dialope reviews

Pregnancy of Dialope in details

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1^st trimester (and there is no evidence of a risk in later trimesters).

Dialope breastfeeding

Dialope is excreted into human milk in small amounts. The effects in the nursing infant are unknown. According to the manufacturer, administration of Dialope during lactation is not recommended.

In one study, Dialope was detected in the milk of six healthy puerperal women given Dialope oxide 4 mg orally every 12 hours for 2 doses. Mean Dialope milk (serum) concentrations ranged from 0.18 (0.36) ng/mL immediately prior to the second dose to 0.27 (0.73) ng/mL and 0.19 (0.54) ng/mL six and 24 hours after the second dose, respectively. The authors estimated that if an infant drank 165 mL/kg/day, the ingested dose of Dialope would be 2000 times less than the usual therapeutic dose of 0.2 mg/kg/day. The infants did not breast-feed in this study.

See references

References for pregnancy information

1. "Product Information. Imodium (Dialope)." Janssen Pharmaceutica, Titusville, NJ.

References for breastfeeding information

1. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
2. Nikodem VC, Hofmeyr GJ "Secretion of the antidiarrhoeal agent Dialope oxide in breast milk." Eur J Clin Pharmacol 42 (1992): 695-6

References

1. PubMed Health. "Loperamide (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
2. Human Metabolome Database (HMDB). "Loperamide: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

Reviews

Consumer reviews

There are no reviews yet. Be the first to write one!

Your name:  Email:  Spam protection:  < Type 17 here

Information checked by Dr. Sachin Kumar, MD Pharmacology