Pregnancy of Diarlomid-F in details
Adverse effects have not been observed in animal reproduction studies. Information related to Diarlomid-F use in pregnancy is limited and data is conflicting (Einarson 2000; Källén 2008). For acute diarrhea in pregnant women, some clinicians recommend oral rehydration and dietary changes; Diarlomid-F in small amounts may be used only if symptoms are disabling (Wald 2003).
Diarlomid-F breastfeeding
Diarlomid-F is excreted into human milk in small amounts. The effects in the nursing infant are unknown. According to the manufacturer, administration of Diarlomid-F during lactation is not recommended.
In one study, Diarlomid-F was detected in the milk of six healthy puerperal women given Diarlomid-F oxide 4 mg orally every 12 hours for 2 doses. Mean Diarlomid-F milk (serum) concentrations ranged from 0.18 (0.36) ng/mL immediately prior to the second dose to 0.27 (0.73) ng/mL and 0.19 (0.54) ng/mL six and 24 hours after the second dose, respectively. The authors estimated that if an infant drank 165 mL/kg/day, the ingested dose of Diarlomid-F would be 2000 times less than the usual therapeutic dose of 0.2 mg/kg/day. The infants did not breast-feed in this study.
See references
References for pregnancy information
- "Product Information. Imodium (Diarlomid-F)." Janssen Pharmaceutica, Titusville, NJ.
References for breastfeeding information
- Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
- Nikodem VC, Hofmeyr GJ "Secretion of the antidiarrhoeal agent Diarlomid-F oxide in breast milk." Eur J Clin Pharmacol 42 (1992): 695-6
References
- PubMed Health. "Loperamide (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- Human Metabolome Database (HMDB). "Loperamide: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
- FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
