Dicyclomine Hcl Pregnancy

• Pregnancy of Dicyclomine Hcl in details
• Dicyclomine Hcl breastfeeding
• Dicyclomine Hcl reviews

Pregnancy of Dicyclomine Hcl in details

In epidemiologic studies, birth defects were not observed following maternal doses up to 40 mg daily throughout the first trimester; information has not been located when used in pregnant women at recommended doses (80 to 160 mg daily). Agents other than Dicyclomine Hcl may be preferred for the treatment of irritable bowel syndrome in pregnant women (Enck 2016).

Dicyclomine Hcl breastfeeding

Use should be avoided. Excreted into human milk: Yes Excreted into animal milk: Data not available Comments: A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

A single case has been reported of a breast-fed 12 day old infant who developed apnea whose mother was receiving Dicyclomine Hcl. A causal relationship between Dicyclomine Hcl and apnea could not be confirmed. Similar adverse reactions have occurred with direct administration of Dicyclomine Hcl to infants.

See references

References for pregnancy information

1. Williams J, Watkins-Jones R "Dicyclomine Hcl: worrying symptoms associated with its use in some small babies." Br Med J (Clin Res Ed) 288 (1984): 901
2. Huff PS "Safety of drug therapy for nausea and vomiting of pregnancy." J Fam Pract 11 (1980): 969-70
3. Altman PM "Debendox withdrawn." Med J Aust 140 (1984): 119
4. Congenital Abnormalities Sub-Committee of the Australian Drug Evaluation Committtee "Debendox in pregnancy." Med J Aust 1 (1980): 197
5. Miklovich L, van den Berg BJ "An evaluation of the teratogenicity of certain antinauseant drugs." Am J Obstet Gynecol 125 (1976): 244-8
6. Correy JF, Newman NM "Debendox and limb reduction deformities." Med J Aust 1 (1981): 417-8
7. Correy JF, Newman NM "Debendox withdrawn." Med J Aust 140 (1984): 796-7
8. Sheffield LJ, Batagol R "The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?" Med J Aust 143 (1985): 143-7
9. DonnaiD, Harris R "Unusual fetal malformations after antiemetics in early pregnancy." Br Med J 1 (1978): 691-2
10. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
11. Gordon I "Debendox." Med J Aust 144 (1986): 51-2
12. Fleming DM, Knox JD, Crombie DL "Debendox in early pregnancy and fetal malformation." Br Med J (Clin Res Ed) 283 (1981): 99-101
13. Mellor S "Fetal malformation after debendox treatment in early pregnancy." Br Med J 1 (1978): 1055
14. Wheatley D "Treatment of pregnancy sickness." Br J Obstet Gynaecol 84 (1977): 444-7
15. Patterson DC "Congenital deformities associated with Benedectin." Can Med Assoc J 116 (1977): 1348
16. Cordero JF, Oakley GP Jr "Drug exposure during pregnancy: some epidemiologic considerations." Clin Obstet Gynecol 26 (1983): 418-28
17. "Product Information. Bentyl (Dicyclomine Hcl)." Aventis Pharmaceuticals, Kansas City, MO.
18. Dickson JH "Congenital deformities associated with bendectin." Can Med Assoc J 117 (1977): 721-2
19. Smithells RW, Sheppard S "Fetal malformation after debendox treatment in early pregnancy." Br Med J 1 (1978): 1055-6
20. Harris R, Donnai D "Debendox and the media." Br Med J 280 (1980): 480-1
21. Morelock S, Hingson R, Kayne H, Dooling E, Zuckerman B, Day N, Alpert JJ, Flowerdew G "Bendectin and fetal development. A study of Boston City Hospital." Am J Obstet Gynecol 142 (1982): 209-13
22. Harron DW, Griffiths K, Shanks RG "Debendox and congenital malformations in Northern Ireland." Br Med J 281 (1980): 1379-81
23. Shapiro S, Heinonen OP, Siskind V, Kaufman DW, Monson RR, Slone D "Antenatal exposure to doxylamine succinate and Dicyclomine Hcl hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score." Am J Obstet Gynecol 128 (1977): 480-5
24. Golden SM, Perman KI "Bilateral clinical anophthalmia: drugs as potential factors." South Med J 73 (1980): 1404-7
25. Gibson GT, Colley DP, McMichael AJ, Hartshorne JM "Congenital anomalies in relation to the use of doxylamine/Dicyclomine Hcl and other antenatal factors: an ongoing prospective study." Med J Aust 1 (1981): 410-4
26. Mitchell AA "Debendox." Med J Aust 144 (1986): 52
27. Maling TJ "Debendox: a statement from the New Zealand Adverse Drug Reactions Committee." N Z Med J 97 (1984): 203-4

References for breastfeeding information

1. "Product Information. Bentyl (Dicyclomine Hcl)." Aventis Pharmaceuticals, Kansas City, MO.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):

References

1. PubMed Health. "Dicyclomine (By injection): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
2. Human Metabolome Database (HMDB). "Dicyclomine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology