What happens if I overdose Dopin?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.
Proper storage of Dopin:
Store Dopin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dopin out of the reach of children and away from pets.
Overdose of Dopin in details
Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. In humans, experience with intentional overdosage of Dopin besylate is limited.
Single oral doses of Dopin maleate equivalent to 40 mg Dopin/kg and 100 mg Dopin/kg in mice and rats, respectively, caused deaths. Single oral Dopin maleate doses equivalent to 4 or more mg Dopin/kg or higher in dogs (11 or more times the maximum recommended human dose on a mg/m2 basis) caused a marked peripheral vasodilation and hypotension.
If massive overdose should occur, initiate active cardiac and respiratory monitoring. Frequent blood pressure measurements are essential. Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. If hypotension remains unresponsive to these conservative measures, consider administration of vasopressors (such as phenylephrine) with attention to circulating volume and urine output. As Dopin besylate is highly protein bound, hemodialysis is not likely to be of benefit.
What should I avoid while taking Dopin?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Dopin.
Dopin warnings
Hypotension
Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. Because of the gradual onset of action, acute hypotension is unlikely.
Increased Angina or Myocardial Infarction
Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of Dopin besylate tablets, particularly in patients with severe obstructive coronary artery disease.
Patients with Hepatic Failure
Because Dopin besyaate is extensively metabolized by the liver and the plasma elimination half-life (t1/2) is 56 hours in patients with impaired hepatic function, titrate slowly when administering Dopin besylate to patients with severe hepatic impairment.
What should I discuss with my healthcare provider before taking Dopin?
- If you have an allergy to Dopin or any other part of Dopin (Dopin suspension).
- If you are allergic to Dopin (Dopin suspension); any part of Dopin (Dopin suspension); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Dopin (Dopin suspension) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Dopin precautions
Heart Failure: In a long-term, placebo-controlled study (PRAISE-2) of Dopin in patients with NYHA III and IV heart failure of non-ischaemic aetiology, Dopin was associated with increased reports of pulmonary oedema despite no significant difference in the incidence of worsening heart failure as compared to placebo.
Hepatic Impairment: As with all calcium antagonists, Dopin's half-life (t½) is prolonged in patients with impaired liver function and dosage recommendations have not been established. Dopin should therefore be administered with caution in these patients.
There are no data to support the use of Dopin alone, during or within 1 month of a myocardial infarction.
The safety and efficacy of Dopin in hypertensive crisis has not been established.
Renal Impairment: Changes in Dopin plasma concentrations are not correlated with degree of renal impairment, therefore, the normal dosage is recommended. Dopin is not dialysable.
Use in pregnancy & lactation: Safety of Dopin in human pregnancy or lactation has not been established. Dopin does not demonstrate toxicity in animal reproductive studies other than to delay parturition and prolong labor in rats at a dose level 50 times the maximum recommended dose in humans. Accordingly, use in pregnancy is only recommended when there is no safer alternative and when the disease itself carries greater risk for the mother and fetus.
Use in children: Not recommended.
Use in the
Elderly: Dopin, used at similar doses in elderly or younger patients, is equally well-tolerated. Therefore, normal dosage regimens are recommended.
What happens if I miss a dose of Dopin?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DailyMed. "FLUOXETINE HYDROCHLORIDE; OLANZAPINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "Dothiepin". http://www.drugbank.ca/drugs/DB09167 (accessed September 17, 2018).
- DrugBank. "dopamine". http://www.drugbank.ca/drugs/DB00988 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
