Dosulepin Hydrochloride indications
Oral
Depression
Adult: Initially, 75 mg daily as a single or in divided doses at night, may increase to 150 mg daily. In severe cases, may increase up to 225 mg daily.
Elderly: Initially, 50-75 mg daily in divided doses.
Maintenance: Half the normal adult dose.
Hepatic impairment: Contraindicated.
Uses of Dosulepin Hydrochloride in details
Dosulepin Hydrochloride also called as dothiepin is used to treat major depressive disorders and neuropathic pain.
Dosulepin Hydrochloride description
Dosulepin Hydrochloride (INN, BAN) formerly known as dothiepin (USAN), and marketed under the brand names Dosulepin Hydrochloride, Dothep, Thaden, and Dopress, is a tricyclic antidepressant that is used in several European and South Asian countries, as well as Australia, South Africa, and New Zealand. It is not used in the United States.
Dosulepin Hydrochloride dosage
Oral
Depression
Adult: Initially, 75 mg daily as a single or in divided doses at night, may increase to 150 mg daily. In severe cases, may increase up to 225 mg daily.
Elderly: Initially, 50-75 mg daily in divided doses.
Maintenance: Half the normal adult dose.
Hepatic impairment: Contraindicated.
Dosulepin Hydrochloride interactions
Increased risk of ventricular arrhythmias w/ drugs that prolong QT interval. May potentiate sedative effect w/ barbiturates, tranquilisers, CNS depressants. May block antihypertensive effect of guanethidine and other adrenergic neurone blocking drugs. May potentiate effects of anticholinergics, antihistamines, sympathomimetics. Increased risk of postural hypotension w/ diuretics. May antagonise effect of antiepileptics.
Potentially Fatal: Concomitant admin w/ MAOIs or w/in 14 days after discontinuation may cause cerebral excitation followed by coma or dangerous hyperthermia.
Dosulepin Hydrochloride side effects
Drowsiness, dizziness, tremor, confusional states, paraesthesia, EEG patterns alterations, disorientation; dry mouth, urinary retention, sweating; hypotension, postural hypotension, tachycardia, arrhythmias (including ventricular tachycardia, ventricular fibrillation and torsades de pointes), conduction defects, palpitations; increased or decreased libido; constipation, nausea, vomiting; blurred vision. Rarely, dysarthria, extrapyramidal symptoms, paralytic ileus, tremor, neuroleptic malignant syndrome, precipitation of angle-closure glaucoma.
Dosulepin Hydrochloride contraindications
Manic phase of bipolar disorder, arrhythmias, heart block, immediate recovery period after MI. Hepatic impairment. Concomitant admin w/ MAOIs or w/in 14 days after discontinuation.
Active ingredient matches for Dosulepin Hydrochloride:
Dosulepin Hydrochloride
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Information checked by Dr. Sachin Kumar, MD Pharmacology
