What is Doxyline EMC?
Doxyline EMC is a tetracycline antibiotic. It fights bacteria in the body.
Doxyline EMC is used to treat many different bacterial infections, such as acne, urinary tract infections, intestinal infections, eye infections, gonorrhea, chlamydia, periodontitis (gum disease), and others.
Doxyline EMC is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. Doxyline EMC will not treat facial redness caused by rosacea.
Some forms of Doxyline EMC are used to prevent malaria, to treat anthrax, or to treat infections caused by mites, ticks, or lice.
Doxyline EMC may also be used for purposes not listed in this medication guide.
Doxyline EMC indications
Infectious-inflammatory diseases caused by microorganisms sensitive to Doxyline EMC including infections of the respiratory and ENT organs; gastrointestinal tract infections; purulent infections of skin and soft tissues (including acne); infection of the genitourinary system (including gonorrhea, primary and secondary syphilis); typhus, brucellosis, rickettsiosis, osteomyelitis, trachoma, chlamydia.
How should I use Doxyline EMC?
Use Doxyline EMC as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Doxyline EMC kit contains antibiotic capsules and a cleanser.
- To use the cleanser:
- Wet the skin. Pump the cleanser into your hands and gently massage it into the skin. Rinse thoroughly with water and pat dry with a soft towel.
- To take the antibiotic:
- Take Doxyline EMC by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Take Doxyline EMC with a full glass of water (8 oz/240 mL) and drink plenty of fluids to prevent ulcers and reduce throat irritation.
- Do not eat or drink calcium-rich foods (eg, milk or other dairy products, calcium-enriched juices) or take an antacid that has aluminum, calcium, or magnesium in it; bismuth subsalicylate; iron; urinary alkalinizers (eg, sodium bicarbonate); or multivitamins with minerals within 2 hours before or 2 hours after you take Doxyline EMC.
- Use Doxyline EMC on a regular schedule to get the most benefit from it. It may take several days to weeks to see the full effect of Doxyline EMC.
- To clear up your infection completely, take Doxyline EMC for the full course of treatment. Keep taking it even if your condition improves in a few days.
- Do not use Doxyline EMC if it is past the expiration date on the bottle.
- If you miss a dose of Doxyline EMC, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Doxyline EMC.
Uses of Doxyline EMC in details
Use: Labeled Indications
Acne: Adjunctive therapy in severe acne.
Actinomycosis: Treatment of actinomycosis caused by Actinomyces israelii when penicillin is contraindicated.
Acute intestinal amebiasis: Adjunct to amebicides in acute intestinal amebiasis.
Anthrax, including inhalational anthrax (postexposure): Treatment of anthrax caused by Bacillus anthracis, including inhalational (postexposure) prophylaxis; to reduce the incidence or progression of disease following exposure to aerosolized B. anthracis.
Cholera: Treatment of cholera infections caused by Vibrio cholerae.
Clostridium: Treatment of infections caused by Clostridium spp. when penicillin is contraindicated.
Gram-negative infections: Treatment of infections caused by Escherichia coli, Enterobacter aerogenes, Shigella spp., Acinetobacter spp., Klebsiella spp. (respiratory and urinary infections), and Bacteroides spp.; Neisseria meningitidis (when penicillin is contraindicated).
Gram-positive infections: Treatment of infections caused by Streptococcus spp., when susceptible.
Listeriosis: Treatment of listeriosis due to Listeria monocytogenes when penicillin is contraindicated.
Malaria prophylaxis: Prophylaxis of malaria due to Plasmodium falciparum in short-term travelers (under 4 months) to areas with chloroquine and/or pyrimethamine-sulfadoxine-resistant strains.
Mycoplasma pneumoniae: Treatment of infections caused by Mycoplasma pneumoniae.
Ophthalmic infections:
Treatment of inclusion conjunctivitis or trachoma caused by Chlamydia trachomatis.
Periodontitis (20 mg tablet and capsule [Periostat (Canadian product)] only): Adjunct to scaling and root planing to promote attachment level gain and to reduce pocket depth in patients with adult periodontitis.
Relapsing fever: Treatment of relapsing fever caused by Borrelia recurrentis.
Respiratory tract infections: Treatment of respiratory infections caused by Haemophilus influenzae, Klebsiella spp., or Mycoplasma pneumoniae; treatment of upper respiratory tract infections caused by Streptococcus pneumoniae; respiratory infections caused by Staphylococcus aureus (Doxyline EMC is not the drug of choice in the treatment of any type of staphylococcal infection).
Rickettsial infections: Treatment of Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae.
Rosacea (Doxyline EMC, Apprilon [Canadian product] only): Treatment of only inflammatory lesions (papules and pustules) of rosacea in adults.
Sexually transmitted infections: Treatment of lymphogranuloma venereum and uncomplicated urethral, endocervical, or rectal infections caused by Chlamydia trachomatis; granuloma inguinale (donovanosis) caused by Klebsiella granulomatis; chancroid caused by Haemophilus ducreyi; nongonococcal urethritis caused by Ureaplasma urealyticum; when penicillin is contraindicated, uncomplicated gonorrhea caused by Neisseria gonorrhea and syphilis caused by Treponema pallidum.
Note: The CDC sexually transmitted disease guidelines recommend dual antimicrobial therapy be used for uncomplicated gonorrhea due to N. gonorrhea resistance concerns; ceftriaxone is the preferred cephalosporin and Doxyline EMC is an alternative option for the second antimicrobial only in cases of azithromycin allergy (CDC [Workowski 2015]).
Skin and skin structure infections (Avidoxy only): Treatment of skin and skin structure infections caused by Staphylococcus aureus (Doxyline EMC is not the drug of choice in the treatment of any type of staphylococcal infection).
Vincent infection: Treatment of Vincent infection caused by Fusobacterium fusiforme when penicillin is contraindicated.
Yaws: Treatment of yaws caused by Treponema pallidum subspecies pertenue when penicillin is contraindicated.
Zoonotic infections: Treatment of psittacosis (ornithosis) caused by Chlamydophila psittaci; plague due to Yersinia pestis; tularemia caused by Francisella tularensis; brucellosis caused by Brucella spp. (in conjunction with streptomycin); bartonellosis caused by Bartonella bacilliformis; infections caused by Campylobacter fetus.
Off Label Uses
Anaplasmosis and ehrlichiosis
Based on the IDSA guidelines for the clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis (HGA) and babesiosis and the Centers for Disease Control and Prevention (CDC) guideline for the diagnosis and management of tickborne rickettsial diseases, Doxyline EMC is effective and recommended for the treatment of human anaplasmosis (also known as HGA) and human ehrlichiosis.
Bartonella infections in HIV-infected patients
Based on the US Department of Health and Human Services (HHS) guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents, Doxyline EMC is a recommended and effective agent for treatment of bacillary angiomatosis, peliosis hepatis, bacteremia, osteomyelitis, CNS infections, infective endocarditis, and other severe infections due to Bartonella in adolescent and adult HIV-infected patients.
Bite wound infection (animal or human bite)
Based on the IDSA guidelines for the diagnosis and management of SSTIs, Doxyline EMC is an acceptable alternative agent for the prophylaxis and treatment of bite wounds (animal or human).
Cellulitis, mild to moderate
Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and management of skin and soft tissue infections (SSTIs) and the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, Doxyline EMC is an effective and recommended treatment option for SSTIs caused by MRSA, particularly purulent cellulitis due to community-acquired MRSA (CA-MRSA).
Chronic obstructive pulmonary disease, acute exacerbation
Data from a randomized, double-blind, placebo-controlled trial support the use of Doxyline EMC in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD).
Based on the American College of Chest Physicians diagnosis and management of lung cancer clinical practice guidelines, intrapleural Doxyline EMC is effective and recommended in the management of recurrent, symptomatic, malignant pleural effusions.
Proctitis, acute or proctocolitis
Based on the CDC sexually transmitted diseases treatment guidelines, Doxyline EMC in combination with ceftriaxone is an effective and recommended agent in the treatment of acute proctitis or proctocolitis.
Prosthetic joint infection
Based on the IDSA guidelines for the management of prosthetic joint infection, Doxyline EMC is an effective and recommended agent for treatment (oral phase) of prosthetic joint infection and for chronic oral antimicrobial suppression of prosthetic joint infection due to staphylococci or Cutibacterium acnes.
Surgical prophylaxis, uterine evacuation (induced abortion or pregnancy loss)
Based on the American College of Obstetricians and Gynecologists guidelines for prevention of infection after gynecologic procedures, Doxyline EMC is effective and recommended as antimicrobial prophylaxis for uterine evacuation procedures for induced abortion or pregnancy loss.
Doxyline EMC description
Doxyline EMC is an antihistamine of the piperazine derivative family.
Doxyline EMC dosage
Doxyline EMC is indicated for adults orally or IV (infusions) in 200 mg / day dosess on the first day of treatment, in the coming days at 100-200 mg / day. Multiplicity of admission (or IV infusion) is 1-2 times / day. For children older than 8 years of age and weighing over 50 kg the daily Doxyline EMC dose for oral administration or IV (infusion) in the first day of treatment is 4 mg / kg. In next days ir is 2-4 mg / kg depending on the severity of the clinical course of disease. Multiplicity of admission (or intravenous infusion) is 1-2 times / day. The recommended minimum time for IV infusion 100 mg of Doxyline EMC (a concentration of infusion solution is 0.5 mg / ml) is 1 hour.
Maximum doses: for adults for oral administration is 300 mg / day or 600 mg / day (depending on the etiology of the agent); for iv injection it is 300 mg / day.
Doxyline EMC interactions
See also:
What other drugs will affect Doxyline EMC?
Medications containing metal ions (antacids, products containing iron, magnesium, calcium) form inactive chelates with Doxyline EMC, in connection with what it is necessary to avoid their simultaneous use.
It needed to avoid combination with penicillins, cephalosporins, bactericidal action and is an antagonist of bacteriostatic antibiotics (including Doxyline EMC).
Absorption of Doxyline EMC is reduced by cholestyramine and colestipol (observe the interval between the reception of at least 3 h).
Due to suppression of intestinal microflora Doxyline EMC reduces prothrombin index which requires dose adjustment of indirect anticoagulants.
Doxyline EMC reduces the reliability of contraception and increases the frequency of breakthrough bleeding while taking estrogen-containing oral contraceptives.
Simultaneous administration of Doxyline EMC with:
Doxyline EMC side effects
See also:
What are the possible side effects of Doxyline EMC?
Digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dysphagia, glossitis, esophagitis, transient increase in the blood of hepatic transaminases, alkaline phosphatase, bilirubin.
Hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia.
Allergic reactions: skin rash, itching, eosinophilia, rarely - angioedema, photosensitivity.
Other: increased residual nitrogen, candidiasis, intestinal dysbiosis, discoloration of teeth in children.
Doxyline EMC contraindications
See also:
What is the most important information I should know about Doxyline EMC?
Pregnancy, children age up to 8 years (possibility of forming insoluble complexes with calcium in the skeleton, enamel and dentin of the teeth), hypersensitivity to tetracyclines, porphyria, severe liver insufficiency, leukopenia, lactation period, myasthenia (for IV administration).
Active ingredient matches for Doxyline EMC:
Doxycycline HCl in Singapore.
| Unit description / dosage (Manufacturer) | Price, USD |
| Doxyline EMC 100 mg x 1000's | |
List of Doxyline EMC substitutes (brand and generic names): | |
| Domycine (Singapore) | |
| Domycine 100 mg x 1's | |
| Domycine 100 mg x 500's | |
| Domycine 100 mg x 1000's | |
| Doxycycline YY (Vietnam) | |
| Doxycycline YY 125 mg x 1 Bottle 100 Tablet | |
| Doxymycin 多喜黴素 (Hongkong) | |
| Doxymycin-100 (Singapore) | |
| Doxymycin-100 100 mg x 500's | |
| Umidox (Vietnam) | |
| Umidox 100 mg x 10 Blister x 10 Tablet | |
References
- DailyMed. "DOXYCYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "doxycycline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "doxycycline". http://www.drugbank.ca/drugs/DB00254 (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
