Doxyline EMC Pregnancy

• Pregnancy of Doxyline EMC in details
• Doxyline EMC breastfeeding
• Doxyline EMC reviews

Pregnancy of Doxyline EMC in details

Doxyline EMC is contraindicated during pregnancy and lactation. Doxyline EMC crosses the placental barrier. This medication may cause long-term discoloration of the teeth, enamel hypoplasia, inhibition of growth of bones of the fetus and also the development of fatty liver.

If necessary using during lactation patients should stop breastfeeding.

Doxyline EMC breastfeeding

The extent of Doxyline EMC absorption by breastfed infants is unknown. Short-term use in lactating women is not explicitly contraindicated by most manufacturers, but the effects of prolonged Doxyline EMC exposure via breast milk are unknown. Long-term or repeat courses are not recommended during nursing as a theoretical precaution. Theoretical risks of dental staining and inhibition of bone growth in nursing infants are considered unlikely by most experts. Available data indicate that short-term use of Doxyline EMC during lactation is unlikely to be harmful; milk levels are low and calcium in breast milk may inhibit infant absorption. Short-term Doxyline EMC use in nursing mothers is generally considered acceptable by experts. After 2 doses of oral Doxyline EMC (200 mg followed by 100 mg 12 hours later) in 15 nursing mothers, milk Doxyline EMC levels 3 and 24 hours after dosing averaged 0.77 and 0.38 mg/L, respectively.

Oral Doxyline EMC (100 mg per day) was given to 10 mothers. On day 2, milk Doxyline EMC levels 3 and 24 hours after dosing averaged 0.82 and 0.46 mg/L, respectively. Using peak and trough milk level averages in this study, the estimated intake of an infant only fed breast milk averaged about 6% of the maternal weight-adjusted dose. Peak milk levels averaged 0.96 mg/L after a single 100 mg dose (n=3) and 1.8 mg/L after a single 200 mg dose (n=3). After 100 mg orally twice a day for 5 days, milk Doxyline EMC levels were about 3.6 mg/L. In another study, in the immediate postpartum period, peak milk levels were 0.6 mg/L after oral doses of 100 mg (n=3) and averaged 1.1 mg/L after 200 mg (n=11). After a single 200 mg Doxyline EMC dose (n=2), milk levels 2, 4, and 6 hours after the dose averaged 0.8, 0.7, and 0.4 mg/L, respectively.

IV: The manufacturer makes no recommendation regarding use during lactation. Most oral formulations: A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Doxyline EMC hyclate 20 mg: Use is contraindicated. Oracea(R): Use is not recommended. Excreted into human milk: Yes Excreted into animal milk: Data not available Tetracycline (a related drug) is considered compatible with breastfeeding by the American Academy of Pediatrics.

See references

References for pregnancy information

1. Freedman DO "Clinical practice. Malaria prevention in short-term travelers." N Engl J Med 359 (2008): 603-12
2. Inglesby TV, O'Toole T, Henderson DA, et al. "Anthrax as a biological weapon, 2002: updated recommendations for management." JAMA 287 (2002): 2236-52
3. Czeizel AE, Rockenbauer M "Teratogenic study of Doxyline EMC." Obstet Gynecol 89 (1997): 524-8
4. "Low-Dose Doxyline EMC (Oracea) for Rosacea." Med Lett Drugs Ther 49 (2007): 5-6
5. Inglesby TV, Dennis DT, Henderson DA, et al "Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense." JAMA 283 (2000): 2281-90
6. Dennis DT, Inglesby TV, Henderson DA, et al "Tularemia as a biological weapon: medical and public health management." JAMA 285 (2001): 2763-73
7. "Product Information. Oracea (Doxyline EMC)." Collagenex Pharmaceuticals, Newtown, PA.
8. "Product Information. Periostat (Doxyline EMC)" Collagenex Pharmaceuticals, Newtown, PA.
9. "Product Information. Acticlate (Doxyline EMC)." Aqua Pharmaceuticals LLC, Malvern, PA.
10. "Product Information. Vibramycin (Doxyline EMC)." Pfizer US Pharmaceuticals, New York, NY.
11. "Product Information. Adoxa (Doxyline EMC)." Doak Dermatologics Division, Fairfield, NJ.

References for breastfeeding information

1. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
2. "Product Information. Periostat (Doxyline EMC)" Collagenex Pharmaceuticals, Newtown, PA.
3. "Product Information. Oracea (Doxyline EMC)." Collagenex Pharmaceuticals, Newtown, PA.
4. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
5. "Product Information. Vibramycin (Doxyline EMC)." Pfizer US Pharmaceuticals, New York, NY.
6. "Product Information. Adoxa (Doxyline EMC)." Doak Dermatologics Division, Fairfield, NJ.
7. "Product Information. Acticlate (Doxyline EMC)." Aqua Pharmaceuticals LLC, Malvern, PA.
8. Sachs HC; Committee on Drugs "The transfer of drugs and therapeutics into human breast milk: an update on selected topics. " Pediatrics 132 (2013): e796-809
9. Tan KR, Magill AJ, Parise ME, Arguin PM "Doxyline EMC for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis." Am J Trop Med Hyg 84 (2011): 517-31
10. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):

References

1. DailyMed. "DOXYCYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubMed Health. "Vibra-Tabs: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
3. LiverTox. "Doxycycline: LIVERTOX provides up-to-date, accurate, and easily accessed information on the diagnosis, cause, frequency, patterns, and management of liver injury attributable to prescription and nonprescription medications, herbals and dietary supplements. ". https://livertox.nlm.nih.gov//Doxycy... (accessed September 17, 2018).

Reviews

Consumer reviews

Information checked by Dr. Sachin Kumar, MD Pharmacology