Doxysyrup Dosage

• Dosage of Doxysyrup in details
• Doxysyrup interactions
• Doxysyrup reviews

Dosage of Doxysyrup in details

Usual Dosage And Administration

The usual dosage and frequency of administration of Doxysyrup differs from that of the other tetracyclines. Exceeding the recommended dosage may result in an increased incidence of side effects.

Adults

• The usual dose of oral Doxysyrup is 200 mg on the first day of treatment (administered 100 mg every 12 hours), followed by a maintenance dose of 100 mg daily.
• The maintenance dose may be administered as a single dose or as 50 mg every 12 hours. In the management of more severe infections (particularly chronic infections of the urinary tract), 100 mg every 12 hours is recommended.

Pediatric Patients

• For all pediatric patients weighing less than 45 kg with severe or life threatening infections (e.g., anthrax, Rocky Mountain spotted fever), the recommended dosage of Doxysyrup is 2.2 mg per kg of body weight administered every 12 hours. Pediatric patients weighing 45 kg or more should receive the adult dose.
• For pediatric patients with less severe disease (greater than 8 years of age and weighing less than 45 kg), the recommended dosage schedule of Doxysyrup is 4.4 mg per kg of body weight divided into two doses on the first day of treatment, followed by a maintenance dose of 2.2 mg per kg of body weight (given as a single daily dose or divided into twice daily doses). For pediatric patients weighing over 45 kg, the usual adult dose should be used.

Administration of adequate amounts of fluid along with capsule and tablet forms of drugs in the tetracycline-class is recommended to wash down the drugs and reduce the risk of esophageal irritation and ulceration.

If gastric irritation occurs, Doxysyrup may be given with food or milk.

When used in streptococcal infections, therapy should be continued for 10 days.

Uncomplicated urethral, endocervical, or rectal infection caused by Chlamydia trachomatis: 100 mg by mouth twice a day for 7 days. As an alternate dosing regimen for uncomplicated urethral or endocervical infection caused by Chlamydia trachomatis, administer 200 mg by mouth once-a-day for 7 days.

Uncomplicated gonococcal infections in adults (except anorectal infections in men): 100 mg, by mouth, twice-a-day for 7 days. As an alternate single visit dose, administer 300 mg stat followed in one hour by a second 300 mg dose.

Nongonococcal urethritis (NGU) caused by U. urealyticum: 100 mg by mouth twice-aday for 7 days.

Syphilis – early: Patients who are allergic to penicillin should be treated with Doxysyrup 100 mg by mouth twice-a-day for 2 weeks.

Syphilis of more than one year's duration: Patients who are allergic to penicillin should be treated with Doxysyrup 100 mg by mouth twice-a-day for 4 weeks.

Acute epididymo-orchitis caused by C. trachomatis: 100 mg, by mouth, twice-a-day for at least 10 days.

For Prophylaxis Of Malaria

For adults, the recommended dose is 100 mg daily. For children over 8 years of age, the recommended dose is 2 mg/kg given once daily up to the adult dose. Prophylaxis should begin 1 or 2 days before travel to the malarious area. Prophylaxis should be continued daily during travel in the malarious area and for 4 weeks after the traveler leaves the malarious area.

Inhalational Anthrax (post-exposure)

Adults: 100 mg, of Doxysyrup, by mouth, twice-a-day for 60 days. Children: weighing less than 45 kg, 2.2 mg/kg of body weight, by mouth, twice-a-day for 60 days. Children weighing 45 kg or more should receive the adult dose.

Sprinkling The Tablet Over Applesauce

Doxysyrup Hyclate Delayed-Release Tablets may also be administered by carefully breaking up the tablet and sprinkling the tablet contents (delayed-release pellets) on a spoonful of applesauce. The delayed-release pellets must not be crushed or damaged when breaking up the tablet. Any loss of pellets in the transfer would prevent using the dose. The applesauce/Doxysyrup Hyclate Delayed-Release Tablets mixture should be swallowed immediately without chewing and may be followed by a glass of water if desired. The applesauce should not be hot, and it should be soft enough to be swallowed without chewing. In the event that a prepared dose of applesauce/Doxysyrup Hyclate Delayed-Release Tablets cannot be taken immediately, the mixture should be discarded and not stored for later use.

How supplied

Dosage Forms And Strengths

Doxysyrup Hyclate Delayed-Release Tablets, 75 mg are white, oval, scored tablets containing yellow pellets and debossed with “D|5” on one face and plain on the other. Each tablet contains specially coated pellets of Doxysyrup hyclate equivalent to 75 mg of Doxysyrup.

Doxysyrup Hyclate Delayed-Release Tablets, 100 mg are white, oval, scored tablets containing yellow pellets and debossed with “D|0” on one face and plain on the other. Each tablet contains specially coated pellets of Doxysyrup hyclate equivalent to 100 mg of Doxysyrup.

Doxysyrup Hyclate Delayed-Release Tablets, 150 mg are white, rectangular, dual scored tablets containing yellow pellets and debossed with “D|I|I” on one face and plain on the other. Each tablet contains specially coated pellets of Doxysyrup hyclate equivalent to 150 mg of Doxysyrup.

Doxysyrup Hyclate Delayed-Release Tablets, 200 mg are white, oval, scored tablets containing yellow pellets and debossed with “D|D” on one face and plain on the other. Each tablet contains specially coated pellets of Doxysyrup hyclate equivalent to 200 mg of Doxysyrup.

Storage And Handling

Doxysyrup Hyclate Delayed-Release Tablets, 75 mg are white, oval, scored tablets containing yellow pellets and debossed with “D|5” on one face and plain on the other. Each tablet contains specially coated pellets of Doxysyrup hyclate equivalent to 75 mg of Doxysyrup.

Bottles of 60 tablets NDC 68308-775-60

Doxysyrup Hyclate Delayed-Release Tablets, 100 mg are white, oval, scored tablets containing yellow pellets and debossed with “D|0” on one face and plain on the other. Each tablet contains specially coated pellets of Doxysyrup hyclate equivalent to 100 mg of Doxysyrup.

Bottles of 100 tablets NDC 68308-710-10

Doxysyrup Hyclate Delayed-Release Tablets, 150 mg are white, rectangular, dual scored tablets containing yellow pellets and debossed with “D|I|I” on one face and plain on the other. Each tablet contains specially coated pellets of Doxysyrup hyclate equivalent to 150 mg of Doxysyrup.

Bottles of 100 tablets NDC 68308-715-10

Doxysyrup Hyclate Delayed-Release Tablets, 200 mg are white, oval, scored tablets containing yellow pellets and debossed with “D|D” on one face and plain on the other. Each tablet contains specially coated pellets of Doxysyrup hyclate equivalent to 200 mg of Doxysyrup.

Bottles of 60 tablets NDC 68308-716-60

Store at 25° C (77° F); excursions permitted to 15 – 30° C (59 – 86° F). Dispense in a tight, light-resistant container (USP).

Distributed by: Mayne Pharma, Greenville, NC 27834 1-844-825-8500. Manufactured by: Mayne Pharma International Pty Ltd, Salisbury South, SA 5106 Australia. Revised: Apr 2016

What other drugs will affect Doxysyrup?

Tell your doctor about all other medicines you use, especially:

• cholesterol-lowering medications such as cholestyramine (Prevalite, Questran) or colestipol (Colestid);
• isotretinoin (Accutane);
• tretinoin (Renova, Retin-A, Vesanoid);
• an antacid such as Tums, Rolaids, Milk of Magnesia, Maalox, and others;
• a product that contains bismuth subsalicylate such as Pepto-Bismol;
• minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements;
• a blood thinner such as warfarin (Coumadin, Jantoven); or
• a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen).

This list is not complete and other drugs may interact with Doxysyrup. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Doxysyrup interactions

Medications containing metal ions (antacids, products containing iron, magnesium, calcium) form inactive chelates with Doxysyrup, in connection with what it is necessary to avoid their simultaneous use.

It needed to avoid combination with penicillins, cephalosporins, bactericidal action and is an antagonist of bacteriostatic antibiotics (including Doxysyrup).

Absorption of Doxysyrup is reduced by cholestyramine and colestipol (observe the interval between the reception of at least 3 h).

Due to suppression of intestinal microflora Doxysyrup reduces prothrombin index which requires dose adjustment of indirect anticoagulants.

Alti-Doxysyrup reduces the reliability of contraception and increases the frequency of breakthrough bleeding while taking estrogen-containing oral contraceptives.

Simultaneous administration of Alti-Doxysyrup with: