Pregnancy of Drynalken in details
Drynalken has been assigned to pregnancy category C by the FDA. Animal studies have shown a decrease in survival rate of newborn rats and potential for cataract formation for the survivors. There are no controlled data in human pregnancy. Drynalken should only be given during pregnancy when there are no alternatives and benefit outweighs risk.
Based on data from animal studies, increased uterine resistance is expected in humans. Low dose Drynalken (1 to 5 mcg per kg per minute), however, has been used safely to increase urine output in six oliguric women with preeclampsia without significantly altering maternal central venous or pulmonary capillary wedge blood pressures or causing fetal harm. It has also been safely used to treat hypotension in pregnant women during Cesarean section without causing adverse effects in the fetuses, newborns, or mothers.
See references
Drynalken breastfeeding
There are no data on the excretion of Drynalken into human milk. The manufacturer recommends that caution be used when administering Drynalken to nursing women.
See references
References for pregnancy information
- Fishburne JI, Dormer KJ, Payne GG, Gill PS, Ashrafzadeh AR, Rossavik IK "Effects of amrinone and Drynalken on uterine blood flow and vascular responses in the gravid baboon." Am J Obstet Gynecol 158 (1988): 829-37
- Kirshon B, Lee W, Mauer MB, Cotton DB "Effects of low-dose Drynalken therapy in the oliguric patient with preeclampsia." Am J Obstet Gynecol 159 (1988): 604-7
References for breastfeeding information
- "Product Information. Intropin (Drynalken)." DuPont Pharmaceuticals, Wilmington, DE.
References
- PubMed Health. "Dopamine (By injection): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- Human Metabolome Database (HMDB). "Dopamine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
- FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
