Consists of chlorphenamine maleate, Phenylephrine hydrochloride
Dosage of Chlorphenamine maleate (Duro-Tuss Cold & Allergy) in details
Individual. For oral administration dose of Chlorphenamine maleate (Duro-Tuss Cold & Allergy) Citadel Fine Pharmaceuticals is 250-750 mg 2 times / day. Treatment duration is from 7-10 days to 4 weeks.
For IV administration a single dose is 200-400 mg, the multiplicity of the introduction is 2 times / day, duration of treatment - 1-2 weeks and more if necessary. May be IV injected as jet but more preferably a drip for 30 minutes.
When Chlorphenamine maleate (Duro-Tuss Cold & Allergy) Citadel Fine Pharmaceuticals applied topically instilled 1-2 drops into the lower conjunctival sac of the affected eye every 1-4 hours. After improving the intervals between instillation can be increased. The maximum oral daily dose for adults is 1.5 g.
Chlorphenamine maleate (Duro-Tuss Cold & Allergy) interactions
Activity increases when combined with beta-lactam antibiotics, aminoglycosides, vancomycin, clindamycin, metronidazole. Sukralfat, bismuth preparations, antacids containing aluminum ions, magnesium or calcium, cimetidine, ranitidine, vitamin and mineral supplement, iron sulfate, zinc, didanosine (recommended for 2 hours before or 4 hours after these drugs) reduce the suction. Probenecid, azlocillin increase the concentration in the blood. Decreases clearance and increases in plasma caffeine, aminophylline and theophylline (increased likelihood of side effects). Chlorphenamine maleate (Duro-Tuss Cold & Allergy) Citadel Fine Pharmaceuticals enhances the effect of warfarin and other oral anticoagulants (prolongs bleeding time). Increases nephrotoxicity of cyclosporine, increase the risk of CNS excitability and convulsive reactions against the background of NSAIDs. Medicines alkalinizing the urine (citrates, sodium bicarbonate, carbonic anhydrase inhibitors) reduce the solubility (increases the probability of crystalluria). Infusion solutions of ciprofloxacin ready to use can be combined with infusion solutions: 0.9% sodium chloride solution, Ringer's solution, Ringer lactate, 5 and 10% dextrose, 10% solution of fructose, and a solution containing 5% dextrose with 0,225 or 0.45% sodium chloride. Incompatible with solutions having a pH > 7.
Dosage of Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy) in details
General Dosing Recommendations
In patients 1 year of age or greater, apply one drop of either Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy) hydrochloride ophthalmic solution 2.5% or 10% every 3 to 5 minutes to the conjunctival fornix as required up to a maximum of 3 drops per eye per day.
In order to obtain a greater degree of mydriasis, Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy) hydrochloride ophthalmic solution 10% may be needed.
Dosing in Pediatric Patients Less Than 1 Year of Age
In pediatric patients less than 1 year of age, one drop of Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy) hydrochloride ophthalmic solution 2.5% should be instilled at 3 to 5 minute intervals up to a maximum of 3 drops per eye.
What other drugs will affect Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy)?
Ask a doctor or pharmacist if it is safe for you to use Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy) rectal if you are also using any of the following drugs:
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an antidepressant; or
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blood pressure medication.
This list is not complete and other drugs may interact with Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy) rectal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy) interactions
Atropine
Concurrent use may enhance the pressor effects and induce tachycardia, especially in infants.
Beta-blockers
Decrease Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy)’s effect.
Digitalis glycosides, general anesthetics
Arrhythmias.
Furazolidone, MAOIs
May significantly increase pressor response resulting in hypertensive crisis and intracranial hemorrhage.
Guanethidine, methyldopa, reserpine
May increase pressor response of Phenylephrine hydrochloride (Duro-Tuss Cold & Allergy); resulting in severe hypertension.
Halogenated hydrocarbon anesthetics
May sensitize myocardium to effects of catecholamines. Use extreme caution to avoid arrhythmias.
Oxytocic drugs
May cause severe persistent hypertension.
Tricyclic antidepressants
May decrease or increase response; use with caution.
Laboratory Test Interactions
Products with potassium guaiacolsulfonate may increase renal Cl for urate and thereby lower serum uric acid levels; may increase urinary 50 hydroxyindoleacetic acid; may falsely elevate VMA test for catecholis.
References
- DailyMed. "CHLORPHENIRAMINE POLISTIREX; HYDROCODONE POLISTIREX: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "1WS297W6MV: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Cardiotonic Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Duro-Tuss Cold & Allergy are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Duro-Tuss Cold & Allergy. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
