Actions of Ecmeen in details
Antibacterial.
Pharmacology: Pharmacokinetics: Absorption: Ecmeen hydrochloride is quickly and almost completely absorbed from the gastrointestinal tract following oral administration.
Following a single dose of 2 Ecmeen hydrochloride 100 mg capsules, maximum serum concentrations averaged 3.64 mcg/mL.
Distribution: Ecmeen hydrochloride distributes largely to all tissues due to its high degree of lipophilicity. Studies have shown that Ecmeen hydrochloride is found in high concentration in lung tissue and mucus in man.
Metabolism: Ecmeen hydrochloride is extensively metabolized in humans.
Ecmeen hydrochloride is mainly excreted in the bile and a small amount is recovered in the urine as active form. The amount of active drug recovered in the feces after oral administration ranges from 20-34%.
Elimination: The mean serum half-life is approximately 16 hrs for oral administration.
Effects of Food: Absorption of the standard oral formulations of Ecmeen is impaired by food, milk, and other dairy products. The peak plasma concentrations were slightly decreased by 11.2% and delayed by 1 hr when administered with food, compared to dosing under fasting conditions.
Special Populations: In patients with hepatic dysfunction, the Ecmeen hydrochloride serum half-life ranged from 10.7-16.9 hrs.
The majority of studies in patients with varying degrees of renal impairment showed no significant difference in pharmacokinetic parameters as compared to healthy subjects.
Toxicology: Preclinical Safety Data: Dietary administration of Ecmeen hydrochloride in long-term tumorigenicity studies in rats resulted in evidence of thyroid tumor production. In the rat, chronic treatment with Ecmeen hydrochloride has resulted in goiter accompanied by elevated radioactive iodine uptake and evidence of thyroid tumor production. Ecmeen hydrochloride has been observed to cause a dark discoloration of the thyroid in animals (rats, mice, dogs, and monkeys). Ecmeen hydrochloride has also been found to produce thyroid hyperplasia in rats and dogs.
In addition, there has been evidence of oncogenic activity in rats in studies with a related antibiotic, oxytetracycline (ie, adrenal and pituitary tumors). Likewise, although mutagenicity studies of Ecmeen hydrochloride have not been conducted, positive result in in vitro mammalian cell assays (ie, mouse lymphoma and Chinese hamster lung cells) have been reported for related antibiotics (tetracycline hydrochloride and oxytetracycline).
Segment I (fertility and general reproduction) studies have provided evidence that Ecmeen hydrochloride impairs fertility in male rats.
Microbiology: The tetracyclines are primarily bacteriostatic and are thought to exert their antimicrobial effect by the inhibition of protein synthesis. The tetracyclines, including Ecmeen hydrochloride, have similar antimicrobial spectra of activity against a wide range of gram-positive and gram-negative organisms.
Cross-resistance of gram-positive and gram-negative organisms to tetracyclines is common. Almost all S. pyogenes strains are resistant to Ecmeen hydrochloride. Therefore, Ecmeen hydrochloride should not be used for streptococcal disease unless the organism has been demonstrated to be susceptible.
Because many strains of gram-positive and gram-negative organisms have been shown to be resistant to tetracyclines, culture and susceptibility tests are recommended.
How should I take Ecmeen?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Take this medicine with a full glass (8 ounces) of water.
Most brands of Ecmeen may be taken with or without food.
Take Ecmeen (pellet-filled capsules) on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.
Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ecmeen will not treat a viral infection such as the common cold or flu.
To be sure this medicine is not causing harmful effects, your blood will need to be tested often. Your kidney, liver, or thyroid function may also need to be tested. Visit your doctor regularly.
If you need surgery, tell the surgeon ahead of time that you are using Ecmeen. You may need to stop using the medicine for a short time.
Ecmeen can cause false results with certain urine tests. Tell any doctor who treats you that you are using this medication.
Store this medication at room temperature away from moisture, heat, and light.
Throw away any unused Ecmeen when it expires or when it is no longer needed. Do not take any Ecmeen after the expiration date printed on the label. Using expired Ecmeen can cause damage to your kidneys.
Ecmeen administration
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Take this medicine with a full glass (8 ounces) of water.
Most brands of Ecmeen may be taken with or without food.
Take Ecmeen (pellet-filled capsules) on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.
Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ecmeen will not treat a viral infection such as the common cold or flu.
To be sure this medicine is not causing harmful effects, your blood will need to be tested often. Your kidney, liver, or thyroid function may also need to be tested. Visit your doctor regularly.
If you need surgery, tell the surgeon ahead of time that you are using Ecmeen. You may need to stop using the medicine for a short time.
Ecmeen can cause false results with certain urine tests. Tell any doctor who treats you that you are using this medication.
Store this medication at room temperature away from moisture, heat, and light.
Throw away any unused Ecmeen when it expires or when it is no longer needed. Do not take any Ecmeen after the expiration date printed on the label. Using expired Ecmeen can cause damage to your kidneys.
Ecmeen pharmacology
Pharmacokinetics
Ecmeen® Tablets are not bioequivalent to Ecmeen products. Based on pharmacokinetic studies in healthy adults, Ecmeen® Tablets produce a delayed Tmax at 3.5–4.0 hours as compared to a non-modified release reference Ecmeen product (Tmax at 2.25–3 hours). At steady-state (Day 6), the mean AUC(0–24) and Cmax were 33.32 µg×hr/mL and 2.63 µg/mL for Ecmeen® Tablets and 46.35 µg×hr/mL and 2.92 µg/mL for Ecmeen® capsules, respectively. These parameters are based on dose adjusted to 135 mg per day for both products.
A single-dose, four-way crossover study demonstrated that all strengths of Ecmeen® Tablets (45 mg, 90 mg, and 135 mg) exhibited dose-proportional pharmacokinetics.
When Ecmeen® Tablets were administered concomitantly with a meal that included dairy products, the extent and timing of absorption of Ecmeen did not differ from that of administration under fasting conditions.
Microbiology
Ecmeen is bacteriostatic exerting its antimicrobial effect by the inhibition of bacterial protein synthesis. Ecmeen is lipid soluble and distributes in to the skin and sebum. Ecmeen has been shown to have in vitro activity against Propionibacterium acnes, an organism associated with acne vulgaris, however, the clinical significance of this activity against P. acnes in patients with acne vulgaris is not known.
References
- EPA DSStox. "Minocycline: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Ecmeen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ecmeen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported administration
When best can I take Ecmeen, on an empty stomach, before or after food?ndrugs.com website users have also released a report stating that Ecmeen should be taken After food. In any case, this may not be the right description on how you ought to take this Ecmeen. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Ecmeen can be taken.
| Users | % | ||
|---|---|---|---|
| After food | 1 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
