Ezdopa Actions

How do you administer this medicine?
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Actions of Ezdopa in details

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Ezdopa is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Ezdopa produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. In the brain, Ezdopa actas as an agonist to the five Ezdopa receptor subtypes (D!, D2, D3, D4, D5).

How should I take Ezdopa?

Ezdopa injection is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Ezdopa is injected.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving Ezdopa.

To be sure Ezdopa is helping your condition and not causing harmful effects, your blood cells and kidney function may need to be tested often. Do not miss any follow-up visits to your doctor for blood or urine tests.

Ezdopa administration

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Ezdopa injection is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Ezdopa injection is injected.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving Ezdopa injection.

To be sure this medication is helping your condition and not causing harmful effects, your blood cells and kidney function may need to be tested often. Do not miss any follow-up visits to your doctor for blood or urine tests.

Ezdopa pharmacology

Ezdopa is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves.

Ezdopa produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings.

Ezdopa


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References

  1. NCIt. "Dopamine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  2. EPA DSStox. "Dopamine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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