Febrol Plus indications
Management of duodenal ulcer; treatment of gastroesophageal reflux disease (GERD), including erosive esophagitis; therapy for benign gastric ulcer; treatment of pathologic hypersecretory conditions; prevention of upper GI bleeding.
Unlabeled Uses
Prevention of aspiration pneumonia and stress ulcers; herpes virus infection; chronic idiopathic urticaria; anaphylaxis (relieves dermatologic symptoms only); dyspepsia; used before anesthesia to prevent aspiration pneumonitis; treatment of hyperparathyroidism and control of secondary hyperparathyroidism in chronic hemodialysis patient; treatment of chronic viral warts in children.
Febrol Plus description
Each caplet contains acetaminophen 500 mg and Caffeine (Febrol Plus) 65 mg.
Febrol Plus dosage
Adults and Children ≥12 years: Take 1-2 caplets, every 4-6 hours as required. Do not take more frequently than every 4 hrs. Do not take more than 8 caplets in 24 hours. It can be taken on an empty stomach.
Panadol Extra Advance should not be used with other acetaminophen-containing products. Do not exceed the stated dose.
Febrol Plus interactions
The speed of absorption of Paracetamol (Febrol Plus) may be increased by metoclopramide or domperidone and absorption reduced by colestyramine.
The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular use of Paracetamol (Febrol Plus) with increased risk of bleeding. Occasional doses have no significant effect.
The use of drugs which induce hepatic microsomal enzymes, such as anticonvulsants and oral contraceptive steroids, may increase the extent of metabolism of Paracetamol (Febrol Plus), resulting in reduced plasma concentrations of the drug and a faster elimination rate.
Drugs which induce hepatic microsomal enzymes, such as alcohol and barbiturates, may increase the hepatotoxicity of Paracetamol (Febrol Plus), particularly after overdose.
CNS depression or excitation may occur if codeine is given to patients receiving monoamine oxidase inhibitors, or within two weeks of stopping treatment with them. The effects of CNS depressants (including alcohol) may be potentiated by codeine.
Concurrent use of codeine with antidiarrhoeal and antiperistaltic agents may increase the risk of severe constipation. Concomitant use of antimuscarinics or medications with antimuscarinic action may result in an increased risk of severe constipation, which may lead to paralytic ileus and/or urinary retention.
Quinidine can inhibit the analgesic effect of codeine.
Codeine may delay the absorption of mexiletine and thus reduce the antiarrhythmic effect of the latter. Codeine may antagonise the gastrointestinal effects of metoclopramide and domperidone. Cimetidine inhibits the metabolism of opioid analgesics resulting in increased plasma concentrations.
Naltrexone blocks the therapeutic effect of opioids.
Febrol Plus side effects
Adverse effects of Paracetamol (Febrol Plus) are rare, but hypersensitivity including skin rash may occur. There have been a few reports of blood dyscrasias including thrombocytopenia and agranulocytosis, but these were not necessarily causally related to Paracetamol (Febrol Plus).
Codeine can produce constipation and drowsiness. Occasional effects are nausea, vomiting, sweating, facial flushing, dry mouth, blurred or double vision, dizziness, postural hypotension, headache, vertigo, palpitations, allergic reactions (itch, skin rash, facial oedema), and difficulties in micturition (dysuria, increased frequency, decrease in amount). Side-effects which occur rarely include hallucinations, nightmares, restlessness and stomach cramps. The frequency and severity are determined by dosage, duration of treatment and individual sensitivity and are unlikely at this dosage. Tolerance and dependency can occur, especially with prolonged high doses of codeine.
High doses of Caffeine (Febrol Plus) may produce headache, tremor, nervousness and irritability.
Febrol Plus contraindications
Do not use with an MAOI or within 14 days of discontinuing an MAOI
due to risk of drug interaction. At least 5 weeks should be allowed after
stopping FLUOXETINE before treatment with an MAOI
• Do not use with pimozide due to risk of drug interaction or QTc
prolongation
• Do not use with thioridazine due to QTc interval prolongation or
potential for elevated thioridazine plasma levels. Do not use thioridazine
within 5 weeks of discontinuing FLUOXETINE
Active ingredient matches for Febrol Plus:
Caffeine/Paracetamol in Pakistan.
List of Febrol Plus substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Febristak (Lithuania) | |
| Fenbid Fenka Pian (China) | |
| Feva Plus (Bangladesh) | |
| Fibi Plus (Bangladesh) | |
| Fiedol (Paraguay) | |
| Finalín Forte (Ecuador) | |
| Finalín Gripe (Ecuador) | |
| Fortolin Extra (Hong Kong) | |
| Geniol Caf (Chile) | |
| Geralgine-P (Turkey) | |
| Gesic Plus (Bangladesh) | |
| Glotadol Extra (Vietnam) | |
| Glotadol Extra 10 Blister x 6 Tablet | |
| Glotadol Extra 20 Blister x 6 Tablet | |
| Glotadol power (Vietnam) | |
| Glotadol power 10 Blister x 10 Tablet | |
| Grip Stop (Georgia) | |
| Gripac (Colombia) | |
| Gripal (Turkey) | |
| Gripaljin (Turkey) | |
| Gripex Control (Poland) | |
| Gripin (Turkey) | |
| Gripin kase (Turkey) | |
| Hapacol Extra (Vietnam) | |
| Hapacol Extra 10 Blister x 10 Tablet | |
| Head-O (Indonesia) | |
| Head-O 25 x 4's (Otto) | |
| Headache (Singapore) | |
| Headache 1's | |
| Headache 5 mg x 6 Blister x 10 Tablet | |
| Hedex Extra (United Kingdom) | |
| Tablet; Oral; Acetaminophen 500 mg; Caffeine 65 mg (Gsk consumer) | |
| Hepa Plus (Bangladesh) | |
| IDYL Paracetamol/Coffeine (Netherlands) | |
| JUMBO Paracetamol/Coffeïne (Netherlands) | |
| K-Pol (Bangladesh) | |
| Kafa plus Koffein (Switzerland) | |
| Kataljin-p (Turkey) | |
| Kitadol Max (Chile) | |
| Tablet, Film-Coated; Oral; Acetaminophen 500 mg; Caffeine 50 mg (Laboratorios chile) | |
| Kitadol Migrana (Peru) | |
| Knock Plus (Bangladesh) | |
| Kofepar (Poland) | |
| Kombinovani prasak (Serbia) | |
| Kombinovani Prašak (Bosnia & Herzegowina) | |
| Kombinovani Prasak Protiv Bolova (Serbia) | |
| Kruidvat Paracetamol met coffeine (Netherlands) | |
| Leidapharm Paracetamol/Coffeïne (Netherlands) | |
See 437 substitutes for Febrol Plus | |
References
- DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "caffeine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "caffeine". http://www.drugbank.ca/drugs/DB00201 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Febrol Plus are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Febrol Plus. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
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Information checked by Dr. Sachin Kumar, MD Pharmacology
