Actions of Funtas in details
Pharmacology: Pharmacodynamics: Funtas contains Miconazole, an imidazole derivative antifungal drug. Funtas has a broad spectrum of activity and is particularly effective against pathogenic fungi and yeasts including Candida albicans. In addition, it is effective against gram-positive bacteria.
Funtas shows its effect during ergosterol synthesis present on cell cytoplasmic membrane. Funtas changes permeability of mycotic cell Candida species in vitro and inhibits the glucose consumption of the cell.
Pharmacokinetics: Absorption: Funtas persists in the vagina for up to 72 hrs after a single dose. Systemic absorption of Funtas after intravaginal administration is limited, with a bioavailability of 1-2% following intravaginal administration of a 1.2 g dose. Plasma concentrations of Funtas are measurable within 2 hrs of administration in some subjects, with maximal levels seen 12-24 hrs after administration. Plasma concentrations decline slowly, thereafter and were still measurable in most subjects 96 hrs post-dose. Absorption of Funtas by the intravaginal route is very low (approximately 1.4% of dose).
Distribution: Following the insertion of vaginal suppository containing Funtas 1.2 g in a single dose, the average maximum serum concentration is 10.4 mcg/L, and the elimination half-life (t½) is 56.8 hrs. The average serum concentration-time curve has been calculated to be 967 mcg/L/hr. Protein-binding ratio is between 90% and 93%.
Biotransformation: It is metabolized in liver microsomally. There are no active metabolites. The major metabolite formed by oxidative-N-dealkylation is 2,4-diclorophenile-1 H imidazole ethanol and secondary metabolite is oxidative 2,4-dicloromandelic acid by O-dealkylation.
Elimination: Half-life is 24 hrs. Less than 1% is excreted in the urine. Approximately 50%, is usually excreted with feces as unchanged drug.
How should I take Funtas?
Keep Funtas away from the eyes.
Apply enough Funtas to cover the affected area, and rub in gently.
To use the aerosol powder form of Funtas:
- Shake well before using.
- From a distance of 6 to 10 inches, spray the powder on the affected areas. If it is used on the feet, spray it between the toes, on the feet, and in the socks and shoes.
- Do not inhale the powder.
- Do not use near heat, near open flame, or while smoking.
To use the aerosol solution form of Funtas:
- Shake well before using.
- From a distance of 4 to 6 inches, spray the solution on the affected areas. If it is used on the feet, spray it between the toes and on the feet.
- Do not inhale the vapors from the spray.
- Do not use near heat, near open flame, or while smoking.
To use the powder form of Funtas:
- If the powder is used on the feet, sprinkle it between the toes, on the feet, and in the socks and shoes.
When Funtas is used to treat certain types of fungus infections of the skin, an occlusive dressing (airtight covering, such as kitchen plastic wrap) should not be applied over Funtas. To do so may cause irritation of the skin. Do not apply an occlusive dressing over Funtas unless you have been directed to do so by your doctor.
To help clear up your infection completely, keep using Funtas for the full time of treatment, even if your condition has improved. Do not miss any doses.
Dosing
The dose of Funtas will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Funtas. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For aerosol powder, aerosol solution, cream, and powder dosage forms:
- For fungus infections:
- Adults and children—Apply to the affected area(s) of the skin two times a day, morning and evening.
- For fungus infections:
- For cream and lotion dosage forms:
- For sun fungus:
- Adults and children—Apply to the affected area(s) of the skin once a day.
- For sun fungus:
Missed Dose
If you miss a dose of Funtas, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep Funtas inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Funtas administration
Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Funtas buccal is used each morning for 14 days in a row. Follow your doctor's instructions.
Brush your teeth before putting in a buccal tablet. Make sure your hands are dry before handling the tablet.
Place the rounded side of the tablet against your upper gum near your back teeth. Close your mouth and press your finger gently against the side of your cheek for 30 seconds to make sure the tablet stays in place.
Leave the tablet in place until the next morning. Switch the sides of your mouth each morning when using a new tablet.
If any pieces of the tablet remain in your mouth the next morning, rinse your mouth with water before using a new tablet.
Do not crush, chew, or break a Funtas buccal tablet. Do not swallow the tablet whole.
You may eat and drink normally while the tablet is in place, but avoid chewing gum.
During the first 6 hours after placing a buccal tablet in your mouth, if the tablet comes loose try putting it back into place. If it still comes loose, put in a new tablet. If you accidentally swallow a tablet within the first 6 hours of wearing time, drink a full glass of water and put in a new tablet.
After the first 6 hours, if a tablet comes loose or you accidentally swallow it, do not put in a new tablet. Wait until it is time for your next dose to put in a new tablet.
Store at room temperature away from moisture and heat.
Funtas pharmacology
Mechanism of Action
Funtas is an antifungal drug.
Pharmacokinetics
Absorption and Distribution
Salivary
Single dose application of Funtas containing 50 mg of Funtas to the buccalmucosa of 18 healthy volunteers provided mean maximum salivary concentrations of15 mcg/mL at 7 hours after application of the tablet. This provided an average salivaexposure to Funtas estimated from the AUC (0-24h) of 55.23 mcg·h/mL. The pharmacokinetic parameters of Funtas in the saliva of healthy volunteers are provided in Table 4.
Table 4: Pharmacokinetic (PK) Parameters of Funtas in Saliva FollowingApplication of a Single Funtas 50 mg Tablet in Healthy Volunteers (N = 18)
| Salivary PK Parameters (N = 18) | Mean ±SD (Min - Max) |
| AUC0-24h (mcg.h/mL) | 55.2 ±35.1 (0.5 – 128.3) |
| Cmax (mcg/mL) | 15.1 ±16.2 (0.5 – 64.8) |
| Tmax (hour) | 7* (2.0 – 24.1) |
In healthy volunteers, the duration of buccal adhesion was on average 15 hours following a single dose application of Funtas 50 mg.
Plasma
Plasma concentrations of Funtas were below the lower limit of quantification (0.4 mcg/mL) in 157/162 (97%) samples from healthy volunteers following single-doseapplication of Funtas 50 mg. Measurable plasma concentrations ranged from 0.5 to 0.83 mcg/mL.
Plasma concentrations of Funtas evaluated after 7 days of treatment in 40 HIV-positive patients were all below the limit of quantification (0.1 mcg/mL).
Metabolism and Excretion
Most of the absorbed Funtas is metabolized by the liver with less than 1% of theadministered dose found unchanged in urine. In healthy volunteers, the terminal half-life is 24 hours following systemic administration. There are no active metabolites of Funtas.
Food Effect
There was no formal food effect study conducted with Funtas; however, in clinical stud
References
- DailyMed. "MICONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- NCIt. "Miconazole: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Miconazole: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Funtas are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Funtas. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
