• Granisetron HCl indications
• Uses of Granisetron HCl in details
• Granisetron HCl description
• Granisetron HCl dosage
• Granisetron HCl interactions
• Granisetron HCl side effects
• Granisetron HCl contraindications

What is Granisetron HCl?

Granisetron HCl injection is used to prevent nausea and vomiting that may occur after treatment with cancer medicines (chemotherapy or radiation), including high-dose cisplatin. Granisetron HCl is also used to prevent and treat nausea and vomiting that may happen after surgery.

Granisetron HCl is a selective 5-HT3 receptor antagonist. It works in the stomach to block the signals to the brain that cause nausea and vomiting.

Granisetron HCl is to be given only by or under the immediate supervision of your doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Granisetron HCl injection is used in certain patients:

• To prevent the nausea and vomiting that may occur after cancer radiation treatment in patients undergoing bone marrow transplantation.

Granisetron HCl indications

Granisetron HCl Hydrochloride is a potent and highly selective 5-HT3 receptor antagonist indicated for:

The prevention and treatment of nausea and vomiting associated with initial and repeated courses of emetogenic cancer therapy, including high-dose cisplatin.

The prevention and treatment of nausea and vomiting associated with radiotherapy, including total body irradiation and fractionated abdominal radiation.

- The prevention and treatment of postoperative nausea and vomiting.

How should I use Granisetron HCl?

Use Granisetron HCl as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Granisetron HCl. Talk to your pharmacist if you have questions about this information.
• Apply Granisetron HCl 24 to 48 hours before your chemotherapy treatment, or as directed by your doctor.
• Granisetron HCl should be applied to clean, healthy skin on the upper arm. Do not apply to cut, scraped, or irritated skin. Do not use creams, oils, lotions, powders, or any other products that could irritate the skin or prevent the patch from sticking well.
• To apply Granisetron HCl, remove the patch from the sealed pouch. Do not cut or damage the patch. Remove the thin, clear, protective liner. Bend the patch in the middle and remove one-half of the rigid plastic film. Apply the exposed, sticky area of the patch to your skin. Remove the other half of the rigid plastic film and press the whole patch firmly in place against the skin.
• If the patch does not stick well, you may tape the edges with surgical bandages or medical adhesive tape. Do not completely cover the patch with bandages or tape. Do not wrap completely around your arm. Ask your health care provider if you are unsure of what type of dressing you can use.
• Wash your hands immediately after using Granisetron HCl.
• You may shower or bathe normally while wearing the patch. You should avoid activities such as swimming, strenuous exercise, or using a sauna or whirlpool. It is unknown how these activities may affect Granisetron HCl.
• Continue to wear the patch during your chemotherapy and for at least 24 hours after your treatment is completed. Granisetron HCl may be worn for up to 7 days or as directed by your doctor.
• To remove the patch, gently peel it off of your skin and fold the sticky side together. Throw the used patch in the trash away from children and pets. Wash your hands after handling the patch.
• Gently wash the skin with soap and water where the patch was applied.
• If you miss a dose of Granisetron HCl, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Granisetron HCl.

Uses of Granisetron HCl in details

Use: Labeled Indications

Chemotherapy-associated nausea and vomiting: Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy, including high-dose cisplatin (injection and tablets); prevention of nausea and vomiting associated with anthracycline/cyclophosphamide chemotherapy regimens; prevention of nausea and vomiting associated with moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days of duration (transdermal).

Radiation-associated nausea and vomiting: Prevention of nausea and vomiting associated with radiation therapy, including total body radiation and fractionated abdominal radiation (tablets).

Off Label Uses

Prevention of postoperative nausea and vomiting

Based on the Society for Ambulatory Anesthesia Consensus Guidelines for management of postoperative nausea and vomiting, Granisetron HCl may administered prior to the end of surgery to prevent postoperative nausea and vomiting.

Granisetron HCl description

Each mL of preservative-free aqueous solution contains 1.12 mg Granisetron HCl hydrochloride equivalent to Granisetron HCl 1 mg and sodium chloride 9 mg. The solution's pH ranges from 4-6.

Granisetron HCl hydrochloride is an antinauseant and antiemetic agent. It is endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride with a molecular weight of 348.9 (312.4 free base). Its empirical formula is C₁₈H₂₄N₄O·HCl.

Granisetron HCl hydrochloride is a white to off-white solid that is readily soluble in water and normal saline at 20°C. Granisetron HCl injection is a clear, colorless, sterile, nonpyrogenic, aqueous solution for IV administration.

Granisetron HCl dosage

Granisetron HCl Dosage

Generic name: Granisetron HCl hydrochloride 1mg

Dosage form: tablet, film coated; oral solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Emetogenic Chemotherapy

The recommended adult dosage of oral Granisetron HCl (Granisetron HCl hydrochloride) is 2 mg once daily or 1 mg twice daily. In the 2 mg once-daily regimen, two 1 mg tablets or 10 mL of Granisetron HCl

Oral Solution (2 teaspoonfuls, equivalent to 2 mg of Granisetron HCl) are given up to 1 hour before chemotherapy. In the 1 mg twice-daily regimen, the first 1 mg tablet or one teaspoonful (5 mL) of Granisetron HCl

Oral Solution is given up to 1 hour before chemotherapy, and the second tablet or second teaspoonful (5 mL) of Granisetron HCl

Oral Solution, 12 hours after the first. Either regimen is administered only on the day(s) chemotherapy is given. Continued treatment, while not on chemotherapy, has not been found to be useful.

Use in the Elderly, Renal Failure Patients or Hepatically Impaired Patients

No dosage adjustment is recommended.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Radiation (Either Total Body Irradiation or Fractionated Abdominal Radiation)

The recommended adult dosage of oral Granisetron HCl is 2 mg once daily. Two 1 mg tablets or 10 mL of Granisetron HCl

Oral Solution (2 teaspoonfuls, equivalent to 2 mg of Granisetron HCl) are taken within 1 hour of radiation.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Use in the Elderly

No dosage adjustment is recommended.

More about Granisetron HCl (Granisetron HCl)

• Side Effects
• During Pregnancy
• Dosage Information
• Drug Images
• Drug Interactions
• Support Group
• 2 Reviews - Add your own review/rating

Consumer resources

• Granisetron HCl
• Granisetron HCl solution
• Granisetron HCl tablets
• Granisetron HCl (Advanced Reading)

• Other brands: Sancuso

Professional resources

• Granisetron HCl (AHFS Monograph)
• Granisetron HCl (FDA)

Related treatment guides

• Nausea/Vomiting, Chemotherapy Induced
• Nausea/Vomiting, Postoperative
• Nausea/Vomiting, Radiation Induced

Granisetron HCl interactions

See also:
What other drugs will affect Granisetron HCl?

Phenobarbital may induce metabolism of Granisetron HCl. Granisetron HCl is metabolized by hepatic cytochrom P450 3A enzymes, inducers or inhibitors of this enzyme may alter Granisetron HCl´s clearance and half – life.

Granisetron HCl side effects

See also:
What are the possible side effects of Granisetron HCl?

Cardiovascular : Hypertention ( 2%); angina, arrhythmias, syncope (rare).

CNS: CNS stimulation; somnolence (3-5%); insomnia (2-3%); extrapyramidal syndrome (rare).

GI: Nausea (15%); vomiting (9%); decreased appetite (5%); taste disorder (2%).

Hematologic: leukopenia (11%); anemia (4%); thrombocytopenia (3%).

Miscellaneous: shivers (5%); alopecia (3%); hypersensitivity (rare).

Granisetron HCl contraindications

See also:
What is the most important information I should know about Granisetron HCl?

Granisetron HCl hydrochloride are contraindicated in patients with known hypersensitivity to the drug or any of its components.

Active ingredient matches for Granisetron HCl:

Granisetron HCl

List of Granisetron HCl substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Em-ex
G -setron
Granic®
Granisetron - Hameln (Vietnam)
Granisetron - Hameln 1 mg/1 mL x 10 tube x 1 mL
Granisetron - Hameln 1 mg/1 mL x 10 tube x 3 mL
Granisetron Hydrochloride Ben Venue (Vietnam)
Granisetron Hydrochloride Ben Venue 1 mg/1 mL x 10 Bottle
Granitic
Kytril®
Ubitron (Taiwan)
Ubitron 1 mg/1 mL x 1 mL
Ubitron 1 mg/1 mL x 3 mL
Vomstop (Taiwan)
Vomstop 1 mg/1 mL x 1 mL x 1's
Vomstop 1 mg/1 mL x 3 mL x 1's

References

1. DailyMed. "GRANISETRON: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "granisetron". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "granisetron". http://www.drugbank.ca/drugs/DB00889 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Granisetron HCl are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Granisetron HCl. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology