What is Guaifenesin/Pseudoephedrine HCl?
There are many brands and forms of Guaifenesin/Pseudoephedrine HCl available and not all brands are listed on this leaflet.
Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.
Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
Guaifenesin/Pseudoephedrine HCl is a combination medicine used to treat stuffy nose and sinus congestion, and to reduce chest congestion caused by the common cold or flu.
Guaifenesin/Pseudoephedrine HCl may also be used for purposes not listed in this medication guide.
Guaifenesin/Pseudoephedrine HCl indications
The symptomatic relief of upper respiratory tract disorders accompanied by productive cough which benefit from a combination of a nasal decongestant and an expectorant.
How should I use Guaifenesin/Pseudoephedrine HCl?
Use Guaifenesin/Pseudoephedrine HCl as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Guaifenesin/Pseudoephedrine HCl by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- To measure the liquid: Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Drink plenty of water while taking Guaifenesin/Pseudoephedrine HCl.
- If you miss a dose of Guaifenesin/Pseudoephedrine HCl and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Guaifenesin/Pseudoephedrine HCl.
Uses of Guaifenesin/Pseudoephedrine HCl in details
This combination medication is used to temporarily treat cough and runny/stuffy nose (nasal congestion) caused by infections (such as the common cold), allergies (such as hay fever), and other breathing illnesses. This product is usually not used for ongoing cough from smoking or long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by your doctor. Guaifenesin is an expectorant. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier. Pseudoephedrine is a decongestant (sympathomimetic). It reduces nasal congestion by narrowing the blood vessels in the nose.
If you are self-treating with this medication, it is important to read the package instructions carefully before you start using this product to be sure it is right for you.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
How to use E-D
Take this medication by mouth with or without food, as directed by your doctor. If you are self-treating, follow all directions on the product package. To prevent trouble sleeping, do not take this medication close to bedtime. If you are uncertain about any of the information, ask your doctor or pharmacist.
If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
Guaifenesin may have a bitter taste. Swallow capsules and tablets whole. Some tablets may be split if they have a score line and your doctor or pharmacist tells you to do so. Chewable tablets may be swallowed whole or chewed.
Dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed.
Drink plenty of fluids while taking this medication. Fluids will help to break up mucus and clear congestion.
Caffeine can increase the side effects of this medication. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas), eating large amounts of chocolate, or taking nonprescription products that contain caffeine.
Tell your doctor if your condition is accompanied by fever, severe sore throat, rash, persistent headache, or if it persists, returns, or worsens after 7 days. These may be signs of a serious medical problem. Seek immediate medical attention if you think you may have a serious medical problem.
Guaifenesin/Pseudoephedrine HCl dosage
Adult & childn >12 yr 2 tsp. Childn 6-12 yr 1 tsp, <6 yr ½ tsp. To be taken 3 times daily.
Guaifenesin/Pseudoephedrine HCl interactions
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What other drugs will affect Guaifenesin/Pseudoephedrine HCl?
The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.
To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.
Some drugs that may interact with this product include: other decongestants (taken by mouth or sprayed into the nose), tricyclic antidepressants (such as nortriptyline, amitriptyline).
Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.
Pseudoephedrine may decrease the effectiveness of some blood pressure medications (such as beta blockers, reserpine, guanethidine, methyldopa, mecamylamine).
Check the labels on all your medicines (such as cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or blood pressure. Before using these products with this medication, ask your pharmacist how to use them safely.
Pseudoephedrine and guaifenesin are available in both prescription and nonprescription products. Check the labels of all your medications carefully to make sure you are not taking more than one product containing these medications.
The guaifenesin in this product can affect the results of certain lab tests (such as urine levels of certain acids). Make sure laboratory personnel and all your doctors know you use this drug.
This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.
Guaifenesin/Pseudoephedrine HCl side effects
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What are the possible side effects of Guaifenesin/Pseudoephedrine HCl?
Nausea or headache may occur. If either of these effects persist or worsen, tell your doctor or pharmacist promptly.
If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: dizziness, fainting, fast/irregular/pounding heartbeat, mental/mood changes (such as anxiety, confusion, nervousness, irritability), shaking (tremor), trouble sleeping, difficult/painful urination.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Guaifenesin/Pseudoephedrine HCl contraindications
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What is the most important information I should know about Guaifenesin/Pseudoephedrine HCl?
The product is contraindicated in patients who have previously shown intolerance to pseudoephedrine or guaifenesin. It is also contraindicated in persons currently being treated with monoamine oxidase inhibitors, and also within two weeks of stopping such treatment. It is also contraindicated in persons with severe hypertension or severe coronary artery disease.
Active ingredient matches for Guaifenesin/Pseudoephedrine HCl:
Guaifenesin/Pseudoephedrine HCl
List of Guaifenesin/Pseudoephedrine HCl substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Aber-Fed | |
| AbleTex PSE | |
| Ambi 60/580 | |
| AmeFlu long Г±ГґГёm (Vietnam) | |
| AmeFlu long Г±ГґГёm 30 mL/chai | |
| AmeFlu long Г±ГґГёm 60 mL/chai | |
| Contac Head & Chest Congestion | |
| D-PSE/GG | |
| E-D | |
| G-Fed | |
| G-Fed Ped | |
| G-P | |
| G-Phed-PD | |
| G/P 1200/60 | |
| Gfn/pse | |
| Guafedrin | |
| Halotussin PE | |
| Harbertussin PE | |
| K-Gest | |
| Nalex-CR | |
| Nalex-Jr | |
| PanMist S | |
| Q-Tussin PE -AF | |
| Robitussin Cold-Severe Congestion (Singapore) | |
| Robitussin Cold-Severe Congestion 12's | $ 6.80 |
| Robitussin For Chesty Coughs With Congestion | |
| S-Pak | |
| Syramin | |
| T-Moist | |
| Triaminic Expectorant & Pilek (Indonesia) | |
| Triaminic Expectorant & Pilek 60 mL x 1's (Novartis Indonesia) | $ 3.35 |
| Wal-Tussin Cold Severe Congest | |
References
- DailyMed. "PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "GUAIFENESIN; HYDROCODONE BITARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "PSEUDOEPHEDRINE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Guaifenesin/Pseudoephedrine HCl are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Guaifenesin/Pseudoephedrine HCl. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
