What is Guarana seed?
The use of Guarana seed in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.
Guarana seed is also known as Paullinia cupana, paullinia, Brazilian cocoa, Guarana seed bread, Guarana seed paste or gum, and zoom. Guarana seed is also present in some soft drinks imported from South America in a manner similar to American soft-drinks fortified with caffeine.
Guarana seed contains very high concentrations of caffeine and has been used as a stimulant and appetite suppressant.
Guarana seed has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of Guarana seed may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
Guarana seed may also have uses other than those listed in this product guide.
Guarana seed indications
Fatigue and drowsiness; analgesia; apnea of prematurity; respiratory depression.
How should I use Guarana seed?
Use Guarana seed as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Dosing depends on the use and the source of the product.
- Use as directed on the package, unless instructed otherwise by your doctor.
- If you miss taking a dose of Guarana seed for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember your dose every day.
Ask your health care provider any questions you may have about how to use Guarana seed.
Guarana seed interactions
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What other drugs will affect Guarana seed?
Aspirin, clozapine, theophylline
Plasma levels of these agents may be elevated by caffeine, increasing their pharmacologic effects and adverse reactions.
Cimetidine, disulfiram, fluoroquinolones, mexiletine, oral contraceptives
May increase caffeine levels, enhancing the effects.
Lithium
Plasma levels may be reduced by caffeine, decreasing the pharmacologic effect.
Phenytoin, smoking
May decrease caffeine levels.
Laboratory Test Interactions
False-positive elevations in serum urate measured by Bittner method; may increase urine levels of vanillymandelic acid, catecholamines, and 5-hydroxyindoleacetic acid, resulting in false-positive diagnosis of pheochromocytoma and neuroblastoma.
Guarana seed side effects
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What are the possible side effects of Guarana seed?
Cardiovascular
Tachycardia; extrasystoles; palpitations; other cardiac arrhythmias.
CNS
Insomnia; restlessness; excitement; nervousness; tinnitus; scintillating scotoma; muscular tremor; headache; lightheadedness.
Dermatologic
Urticaria; rash, dry skin, skin breakdown (caffeine citrate).
EENT
Retinopathy of prematurity (caffeine citrate).
GI
Vomiting; nausea; diarrhea; stomach pain; necrotizing enterocolitis, gastritis, GI hemorrhage (caffeine citrate).
Genitourinary
Diuresis; kidney failure (caffeine citrate).
Hematologic
Disseminated intravascular coagulation (caffeine citrate).
Metabolic
Hyperglycemia; acidosis (caffeine citrate).
Respiratory
Dyspnea, lung edema (caffeine citrate).
Miscellaneous
Hypersensitivity (eg, dermatitis, rhinitis, bronchial asthma); feeding intolerance, sepsis, accidental injury, hemorrhage, cerebral hemorrhage (caffeine citrate).
Guarana seed contraindications
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What is the most important information I should know about Guarana seed?
Caffeine and sodium benzoate solution in pediatrics
Active ingredient matches for Guarana seed:
Guarana seed
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Information checked by Dr. Sachin Kumar, MD Pharmacology