Dosage of Hc Ketoconazole in details
Hc Ketoconazole Dosage
Generic name: Hc Ketoconazole 200mg
Dosage form: tablet
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
There should be laboratory as well as clinical documentation of infection prior to starting Hc Ketoconazole therapy. The usual duration of therapy for systemic infection is 6 months. Treatment should be continued until active fungal infection has subsided.
Adults
The recommended starting dose of Hc Ketoconazole® (Hc Ketoconazole) Tablets is a single daily administration of 200 mg (one tablet). If clinical responsiveness is insufficient within the expected time, the dose of Hc Ketoconazole® Tablets may be increased to 400 mg (two tablets) once daily.
Children
In small numbers of children over 2 years of age, a single daily dose of 3.3 to 6.6 mg/kg has been used. Hc Ketoconazole® Tablets have not been studied in children under 2 years of age.
More about Hc Ketoconazole (Hc Ketoconazole)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Espanol
- 4 Reviews - Add your own review/rating
Consumer resources
- Hc Ketoconazole
- Hc Ketoconazole (Advanced Reading)
Professional resources
- Hc Ketoconazole (AHFS Monograph)
- Hc Ketoconazole (FDA)
Other formulations
- Hc Ketoconazole
Topical
- Hc Ketoconazole A-D
Related treatment guides
- Blastomycosis
- Chromomycosis
- Coccidioidomycosis
- Histoplasmosis
- Paracoccidioidomycosis
What other drugs will affect Hc Ketoconazole?
Many drugs can interact with Hc Ketoconazole. Below is just a partial list. Tell your doctor if you are using:
- acetaminophen (Tylenol);
- cyclosporine (Gengraf, Sandimmune, Neoral);
- clopidogrel (Plavix);
- digoxin (digitalis, Lanoxin);
- tacrolimus ((Prograf);
- loratadine (Alavert, Claritin, Tavist ND);
- methylprednisolone (Medrol);
- phenytoin (Dilantin);
- rifampin (Rifadin, Rifater, Rifamate, Rimactane);
- diabetes medication you take by mouth;
- a sedative such as midazolam (Versed);
- a blood thinner such as warfarin (Coumadin);
- cancer medications;
- birth control pills or hormone replacement therapy;
- methotrexate (Rheumatrex, Trexall);
- cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or
- medications to treat HIV or AIDS.
This list is not complete and there are many other drugs that can interact with Hc Ketoconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Hc Ketoconazole interactions
Drugs that affect the absorption, distribution, metabolism, and excretion of Hc Ketoconazole may alter the plasma concentrations of Hc Ketoconazole. For example, gastric acid suppressants (e.g., antacids, histamine H2-blockers, proton pump inhibitors) have been shown to reduce plasma concentrations of Hc Ketoconazole.
Hc Ketoconazole is a substrate and potent inhibitor of CYP3A4. Therefore, the following drug interactions may occur when Hc Ketoconazole® is co-administered with other drugs that interact with CYP3A4.
- Hc Ketoconazole® may decrease the elimination of drugs metabolized by CYP3A4, thereby increasing their plasma concentrations. Increased exposure to these drugs may cause an increase or prolongation of their therapeutic and/or adverse effects. Concomitant use with Hc Ketoconazole® Tablets is contraindicated for drugs known to present a risk of serious side effects with increased exposure. For others, monitoring of plasma concentrations is advised when possible. Clinical signs and symptoms associated with these drugs should be monitored, with dosage adjusted as needed.
- Inducers of CYP3A4 may decrease the plasma concentrations of Hc Ketoconazole. Hc Ketoconazole® may not be effective in patients concomitantly taking one of these drugs. Therefore, administration of these drugs with Hc Ketoconazole® is not recommended.
- Other inhibitors of CYP3A4 may increase the plasma concentrations of Hc Ketoconazole. Patients who must take Hc Ketoconazole® concomitantly with one of these drugs should be monitored closely for signs or symptoms of increased or prolonged pharmacologic effects of Hc Ketoconazole®.
Table 1: Selected Drugs That Have Been Shown To or Are Predicted To Have Their Plasma Concentrations Altered By Hc Ketoconazole®*
Systemic exposure to these drugs is increased significantly by the addition of Hc Ketoconazole: Concomitant use with Hc Ketoconazole is contraindicated. | |
Alprazolam, midazolam, triazolam | HMG-CoA reductase inhibitors (lovastatin, simvastatin) |
Cisapride | Nisoldipine |
Dofetilide | Pimozide |
Eplerenone | Quinidine |
Ergot alkaloids (ergotamine, dihydroergotamine) | |
Systemic exposure to these drugs is increased by Hc Ketoconazole: Careful monitoring, with possible adjustment in dosage, is recommended. | |
Alfentanil, fentanyl, sulfentanil | Indinavir, saquinavir |
Amlodipine, felodipine, nicardipine, nifedipine | Methylprednisolone |
Bosentan | Rifabutin |
Buspirone | Sildenafil |
Busulfan | Sirolimus (co-administration not recommended) |
Carbamazepine | Tacrolimus |
Cilostazol | Telithromycin |
Cyclosporine | Tolterodine |
Digoxin | Trimetrexate |
Docetaxel, paclitaxel | Verapamil |
Oral anti-coagulants | Vinca alkaloids (vincristine, - vinblastine, vinorelbine) |
* This list is not all-inclusive. |
Table 2: Selected Drugs That Have Been Shown To or Are Predicted To Alter The Plasma Concentration Of Hc Ketoconazole®
Systemic exposure to Hc Ketoconazole is reduced significantly by these drugs: Concomitant use with Hc Ketoconazole is not recommended. | |
Carbamazepine | Phenytoin |
Gastric Acid Suppressants (antacids, antimuscarinics, histamine H2-blockers, proton pump inhibitors, sucralfate) | Rifampin, rifabutin, isoniazid |
Nevirapine | |
Systemic exposure to Hc Ketoconazole is increased significantly by this drug: Dose reduction of Hc Ketoconazole should be considered | |
Ritonavir | |
* This list is not all-inclusive. |
Effects of Hc Ketoconazole on other drugs
Systemic exposure to the following drugs is significantly increased by co
References
- DailyMed. "KETOCONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "2DJ8R0NT7K: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "14-alpha Demethylase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Hc Ketoconazole are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hc Ketoconazole. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported frequency of use
No survey data has been collected yetConsumer reported doses
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology