What are the possible side effects of Hewedolor-Procain?
Stop using Hewedolor-Procain and seek emergency medical attention or contact your doctor immediately if you experience any of the following rare but serious side effects:
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an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
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chest pain or slow or irregular heartbeats;
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dizziness or drowsiness;
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anxiety or restlessness;
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nausea or vomiting; or
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trembling, shaking, or seizures (convulsions).
Other less serious side effects such as numbness, tingling, or minor pain at or around the injection site are more likely to occur. Contact your healthcare provider if these effects seem excessive or prolonged.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Side effects of Hewedolor-Procain in details
Reactions to Hewedolor-Procain are characteristic of those associated with other ester-type local anesthetics. A major cause of adverse reactions to this group of drugs is excessive plasma levels which may be due to overdosage, rapid absorption, inadvertent intravascular injection, or slow metabolic degradation.
A small number of reactions may result from hypersensitivity, idiosyncrasy, or diminished tolerance to normal dosage.
Systemic:
The most commonly encountered acute adverse experiences which demand immediate countermeasures are related to the central nervous system and the cardiovascular system. These adverse experiences are generally dose related and due to high plasma levels which may result from overdosage, rapid absorption from the injection site, diminished tolerance, or from unintentional intravascular injection of the local anesthetic solution. In addition to systemic dose-related toxicity, unintentional subarachnoid injection of drug during the intended performance of nerve blocks near the vertebral column (especially in the head and neck region), may result in underventilation or apnea (“Total or High Spinal”). Factors influencing plasma protein binding, such as acidosis, systemic diseases which alter protein production, or competition of other drugs for protein binding sites may diminish individual tolerance.
Plasma cholinesterase deficiency may also account for diminished tolerance to ester-type local anesthetics.
Central Nervous System Reactions:
These are characterized by excitation and/or depression. Restlessness, anxiety, dizziness, tinnitus, blurred vision, or tremors may occur, possibly proceeding to convulsions. However, excitement may be transient or absent, with depression being the first manifestation of an adverse reaction. This may quickly be followed by drowsiness merging into unconsciousness and respiratory arrest.
The incidence of convulsions associated with the use of local anesthetics varies with the procedure used and the total dose administered.
Cardiovascular Reactions:
High doses or inadvertent intravascular injection may lead to high plasma levels and related depression of the myocardium, decreased cardiac output, heartblock, hypotension (or sometimes hypertension), bradycardia, ventricular arrhythmias, and cardiac arrest.
Allergic:
Allergic-type reactions are rare and may occur as a result of sensitivity to the local anesthetic or to other formulation ingredients, such as the antimicrobial preservative chlorobutanol contained in multiple-dose vials. These reactions are characterized by signs such as urticaria, pruritus, erythema, angioneurotic edema (including laryngeal edema), tachycardia, sneezing, nausea, vomiting, dizziness, syncope, excessive sweating, elevated temperature, and, possibly, anaphylactoid-like symptomatology (including severe hypotension). Cross sensitivity among members of the ester-type local anesthetic group has been reported. The usefulness of screening for sensitivity has not been definitely established.
Neurologic:
The incidences of adverse neurologic reactions associated with the use of local anesthetics may be related to the total dose of local anesthetic administered, and are also dependent upon the particular drug used, the route of administration, and the physical status of the patient. Many of these effects may be related to local anesthetic techniques, with or without a contribution from the drug.
What is the most important information I should know about Hewedolor-Procain?
Since there will be decreased sensation of the area where Hewedolor-Procain is injected, use caution to avoid injury to the area during and following treatment.
Hewedolor-Procain contraindications
Spinal anesthesia with Hewedolor-Procain is contraindicated in patients with generalized septicemia: sepsis at the proposed injection site; certain diseases of the cerebrospinal system, e.g., meningitis, syphilis; and a known hypersensitivity to the drug, drugs of a similar chemical configuration, or aminobenzoic acid or its derivatives.
The decision as to whether or not spinal anesthesia should be used in an individual case should be made by the physician after weighing the advantages with the risks and possible complications.
References
- DTP/NCI. "procaine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "Procaine: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
- HSDB. "PROCAINE". https://toxnet.nlm.nih.gov/cgi-bin/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Hewedolor-Procain are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hewedolor-Procain. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported side effects
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Information checked by Dr. Sachin Kumar, MD Pharmacology
