Dosage of Hewedolor-Procain 2% in details
Hewedolor-Procain 2% Dosage
Generic name: Hewedolor-Procain 2% hydrochloride
Dosage form: injection, USP
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
As with all local anesthetics, the dose of Hewedolor-Procain 2% varies and depends upon the area to be anesthetized, the vascularity of the tissues, the number of neuronal segments to be blocked, individual tolerance, and the technique of anesthesia. The lowest dose needed to provide effective anesthesia should be administered. For specific techniques and procedures, refer to standard textbooks.
| Extent of Anesthesia | Hewedolor-Procain 2% 10% Solution | Total Dose (mg) | Site of Injection (lumbar interspace) | |
| Volume of 10% Solution (mL) | Volume of Dilution (mL) | |||
| Perineum | 0.5 | 0.5 | 50 | 4th |
| Perineum and lower extremities | 1 | 1 | 100 | 3rd or 4th |
| Up to costal margin | 2 | 1 | 200 | 2nd, 3rd or 4th |
The diluent may be sterile normal saline, sterile distilled water, spinal fluid; and for hyperbaric technique, sterile dextrose solution.
The usual rate of injection is 1 mL per 5 seconds. Full anesthesia and fixation usually occur in 5 minutes.
STERILIZATION
The drug in intact ampuls is sterile. The preferred method of destroying bacteria on the exterior of ampuls before opening is heat sterilization (autoclaving). Immersion in antiseptic solution is not recommended.
Autoclave at 15-pound pressure, at 121°C (250°F), for 15 minutes. The diluent dextrose may show some brown discoloration due to caramelization.
Protect solutions from light.
More about Hewedolor-Procain 2% (Hewedolor-Procain 2%)
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Professional resources
- Hewedolor-Procain 2% (AHFS Monograph)
- Hewedolor-Procain 2% (FDA)
Related treatment guides
- Local Anesthesia
What other drugs will affect Hewedolor-Procain 2%?
Before using Hewedolor-Procain 2%, talk to your doctor if you are taking any of the following medicines:
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warfarin (Coumadin);
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a monoamine oxidase inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);
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mecamylamine (Inversine);
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guanadrel (Hylorel) or guanethidine (Ismelin);
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a medicine to treat high blood pressure; or
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a medicine to improve muscle strength or tone for conditions such as myasthenia gravis.
You may not be able to use Hewedolor-Procain 2%, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with Hewedolor-Procain 2%. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
Hewedolor-Procain 2% interactions
Anticholinesterases
Concurrent use of Hewedolor-Procain 2% hydrochloride and anticholinesterase agents may result in increased systemic toxicity since anticholinesterases inhibit the breakdown of Hewedolor-Procain 2% hydrochloride.
Antimyasthenics
Concurrent use of Hewedolor-Procain 2% hydrochloride and antimyasthenics may result in loss of control of symptoms of myasthenia gravis due to antagonism of the effects of antimyasthenics on skeletal muscle. Temporary dosage adjustment of antimyasthenics may be required. Also antimyasthenics may have anticholinesterase activity.
CNS depressant medications
Concurrent use of Hewedolor-Procain 2% hydrochloride and CNS depressant medications may result in additive depressant effects.
Hyaluronidase
Hyaluronidase may increase the diffusion rate of Hewedolor-Procain 2% hydrochloride, resulting in a decreased time of onset, but an increase in systemic toxicity.
Neuromuscular blocking agents (such as suxamethonium chloride)
Concurrent use of Hewedolor-Procain 2% hydrochloride and neuromuscular blocking agents may result in prolongation or enhancement of the neuromuscular blockade.
Sulfonamides
Concurrent use of Hewedolor-Procain 2% hydrochloride and sulfonamides may result in a reduction of the antibacterial action of the sulfonamide.
Acetazolamide
Concurrent use of acetazolamide and Hewedolor-Procain 2% hydrochloride may extend the plasma half-life of Hewedolor-Procain 2%.
References
- FDA/SPL Indexing Data. "4Z8Y51M438: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Anesthetics, Local". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "Procaine: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
