Human ALBUMIN(BHARAT SERUM) Uses

How times a day do you take this medicine?
sponsored

What is Human ALBUMIN(BHARAT SERUM)?

Human ALBUMIN(BHARAT SERUM) (human) injection is used to treat low blood volume (hypovolemia). It is also used to treat low Human ALBUMIN(BHARAT SERUM) levels in the blood (hypoalbuminemia) caused by: not enough Human ALBUMIN(BHARAT SERUM) produced by the body (eg, malnutrition, burns, major injury, infections), excessive breakdown of Human ALBUMIN(BHARAT SERUM) (eg, burns, major injury, pancreatitis), loss of Human ALBUMIN(BHARAT SERUM) from the body (eg, bleeding, excessive kidney excretion, burn exudates), or redistribution of Human ALBUMIN(BHARAT SERUM) from the body (eg, major surgery, inflammatory conditions).

Human ALBUMIN(BHARAT SERUM) (human) injection is also used to treat hypoalbuminemia in patients with severe injuries, infections, or pancreatitis (swelling of the pancreas) that cannot be quickly reversed and when nutritional supplements have been given but did not work well. It is also used together with crystalloid treatment to correct lower osmotic pressure in the blood and to replace protein loss caused by severe burns after the first 24 hours.

Human ALBUMIN(BHARAT SERUM) (human) injection is used as a priming fluid during cardiopulmonary bypass surgery.

Flexbumin® 25% is used when hypovolemia is long-standing and hypoalbuminemia exists along with enough hydration, or fluid swelling (edema). It is also used together with other medicines (eg, water pill) to treat fluid swelling in the lungs (interstitial pulmonary edema) and hypoproteinemia (low protein levels in the blood) in patients with adult respiratory distress syndrome (ARDS). Flexbumin® 25% is also used to treat swelling in patients with severe nephrosis who are receiving steroids or a water pill. It is also used to treat hemolytic disease of the newborn (HDN) in babies.

Human ALBUMIN(BHARAT SERUM) human is to be given only by or under the direct supervision of your doctor.

Human ALBUMIN(BHARAT SERUM) indications

sponsored

Hypovolemia

Human ALBUMIN(BHARAT SERUM) (Human) 20% is indicated in the emergency treatment of hypovolemia with or without shock. Its effectiveness in reversing hypovolemia depends largely upon its ability to draw interstitial fluid into the circulation. It is most effective in patients who are well hydrated. When blood volume deficit is the result of hemorrhage, compatible red blood cells or whole blood should be administered as quickly as possible. [1, 2]

When hypovolemia is long standing and hypoalbuminemia exists accompanied by adequate hydration or edema, 20% - 25% Human ALBUMIN(BHARAT SERUM) solutions should be used. [ ]

Hypoalbuminemia

For subjects with hypoalbuminemia who are critically ill and/or are bleeding actively, Human ALBUMIN(BHARAT SERUM) (HUMAN) 20% infusions may be indicated. [ ] When Human ALBUMIN(BHARAT SERUM) deficit is the result of excessive protein loss, the effect of administration of Human ALBUMIN(BHARAT SERUM) (Human) 20% will be temporary unless the underlying disorder is reversed.

Prevention of Central Volume Depletion after Paracentesis due to Cirrhotic Ascites (Treatment Adjunct)

Human ALBUMIN(BHARAT SERUM) (Human) 20% may be used to maintain cardiovascular function following the removal of large volumes of ascitic fluid after paracentesis due to cirrhotic ascites. [ ]

Ovarian Hyperstimulation Syndrome (OHSS)

Human ALBUMIN(BHARAT SERUM) (Human) 20% may be used as a plasma expander in fluid management relating to severe forms of ovarian hyperstimulation syndrome (OHSS). [7, 8]

Adult Respiratory Distress Syndrome (ARDS) (Treatment Adjunct)

Human ALBUMIN(BHARAT SERUM) (Human) 20% infusions may be indicated in conjunction with diuretics to correct the fluid volume overload associated with ARDS. [ ]

Acute Nephrosis (Treatment Adjunct)

Human ALBUMIN(BHARAT SERUM) (Human) 20% may be used to treat edema in patients with acute nephrosis who are refractory to cyclophosphamide and corticosteroid therapy. [ ]

Hemolytic Disease of the Newborn (HDN)

Human ALBUMIN(BHARAT SERUM) (Human) 20% is indicated in the treatment of hyperbilirubinemia. It may be used prior to or during an exchange procedure in an attempt to bind free and to enhance its removal. [ ]

How should I use Human ALBUMIN(BHARAT SERUM)?

Use Human ALBUMIN(BHARAT SERUM) (human) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Human ALBUMIN(BHARAT SERUM) (human).

Uses of Human ALBUMIN(BHARAT SERUM) in details

sponsored

Use: Labeled Indications

Acute respiratory distress syndrome (25% solution only): To correct interstitial pulmonary edema and hypoproteinemia associated with acute respiratory distress syndrome in conjunction with diuretics.

Cirrhotic ascites, adjunct treatment: To maintain intravascular volume following removal of large-volume paracentesis in cirrhotic patients.

Erythrocyte resuspension: To avoid excessive hypoproteinemia, during certain types of exchange transfusion, or with the use of very large volumes or previously frozen or washed red cells.

Hypovolemia: Plasma volume expansion and maintenance of intravascular volume in the emergency treatment of hypovolemia (with or without shock).

Neonatal hemolytic disease: Binds and detoxifies unconjugated bilirubin in severe hemolytic disease of the newborn during exchange transfusion.

Nephrosis (acute), adjunct: Treatment of edema in patients with acute nephrosis in combination with diuretics.

Ovarian hyperstimulation syndrome, treatment (25% solution only): As a plasma volume expander in fluid management for the treatment of severe ovarian hyperstimulation syndrome.

Off Label Uses

Cirrhosis (in combination with diuretics to facilitate diuresis)

Data from an unblinded, randomized, controlled study supports the use of Human ALBUMIN(BHARAT SERUM) in the treatment of cirrhosis (in combination with diuretics) to facilitate diuresis. Additional trials may be necessary to further define the role of Human ALBUMIN(BHARAT SERUM) in this condition.

Based on the American Association for the Study of Liver Diseases (AASLD) guidelines for the management of adult patients with ascites due to cirrhosis, Human ALBUMIN(BHARAT SERUM) given for cirrhosis (in combination with diuretics) to facilitate diuresis is possibly effective, but further studies are needed before Human ALBUMIN(BHARAT SERUM) can be recommended for the management of this condition.

Spontaneous bacterial peritonitis (treatment)

American Association for the Study of Liver Diseases and European Association for the Study of the Liver clinical practice guidelines recommend Human ALBUMIN(BHARAT SERUM) in conjunction with antibiotic therapy for treatment of cirrhotic patients with SBP. In controlled trials, the addition of Human ALBUMIN(BHARAT SERUM) to antibiotic therapy was associated with significant reductions in incidences of renal impairment and mortality.

Volume expansion in dehydrated, mildly hypotensive patients with cirrhosis

Based on the American Association for the Study of Liver Diseases (AASLD) guidelines for the management of adult patients with ascites due to cirrhosis, Human ALBUMIN(BHARAT SERUM) given for volume expansion in dehydrated, mildly hypotensive patients with cirrhosis is effective and recommended in the management of this condition.

Human ALBUMIN(BHARAT SERUM) dosage

sponsored

Usual Adult Dose for Peritonitis

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 250 or 500 mL IV at a rate of 1 to 2 mL per minute in the absence of overt shock. The capacity of the administration set is the only limit in the exsanguinated patient. The rate of infusion and total volume administered are determined by the condition and response of the patient. The initial dose may be followed by additional Human ALBUMIN(BHARAT SERUM) within 15 to 30 minutes if the response is inadequate.

Human ALBUMIN(BHARAT SERUM) 25%:

Initial dose: The patient may require 200 to 300 mL IV to reduce edema and to bring serum protein values to normal. Since such patients usually have approximately normal blood volume, doses of more than 100 mL of Human ALBUMIN(BHARAT SERUM) 25% should not be given faster than 100 mL IV over 30 to 45 minutes to avoid circulatory overload. If slower administration is desired, 200 mL of Human ALBUMIN(BHARAT SERUM) 25% may be mixed with 300 mL of 10% dextrose solution and administered by continuous drip at a rate of 100 mL an hour IV.

Usual Adult Dose for Shock

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 250 or 500 mL IV at a rate of 1 to 2 mL per minute in the absence of overt shock. The capacity of the administration set is the only limit in the exsanguinated patient. The rate of infusion and total volume administered are determined by the condition and response of the patient. The initial dose may be followed by additional Human ALBUMIN(BHARAT SERUM) within 15 to 30 minutes if the response is inadequate.

Human ALBUMIN(BHARAT SERUM) 25%:

Initial dose: The patient may require 200 to 300 mL IV to reduce edema and to bring serum protein values to normal. Since such patients usually have approximately normal blood volume, doses of more than 100 mL of Human ALBUMIN(BHARAT SERUM) 25% should not be given faster than 100 mL IV over 30 to 45 minutes to avoid circulatory overload. If slower administration is desired, 200 mL of Human ALBUMIN(BHARAT SERUM) 25% may be mixed with 300 mL of 10% dextrose solution and administered by continuous drip at a rate of 100 mL an hour IV.

Usual Adult Dose for Pancreatitis

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 250 or 500 mL IV at a rate of 1 to 2 mL per minute in the absence of overt shock. The capacity of the administration set is the only limit in the exsanguinated patient. The rate of infusion and total volume administered are determined by the condition and response of the patient. The initial dose may be followed by additional Human ALBUMIN(BHARAT SERUM) within 15 to 30 minutes if the response is inadequate.

Human ALBUMIN(BHARAT SERUM) 25%:

Initial dose: The patient may require 200 to 300 mL IV to reduce edema and to bring serum protein values to normal. Since such patients usually have approximately normal blood volume, doses of more than 100 mL of Human ALBUMIN(BHARAT SERUM) 25% should not be given faster than 100 mL IV over 30 to 45 minutes to avoid circulatory overload. If slower administration is desired, 200 mL of Human ALBUMIN(BHARAT SERUM) 25% may be mixed with 300 mL of 10% dextrose solution and administered by continuous drip at a rate of 100 mL an hour IV.

Usual Adult Dose for Burns - External

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 250 or 500 mL IV at a rate of 1 to 2 mL per minute in the absence of overt shock. The capacity of the administration set is the only limit in the exsanguinated patient. The rate of infusion and total volume administered are determined by the condition and response of the patient. The initial dose may be followed by additional Human ALBUMIN(BHARAT SERUM) within 15 to 30 minutes if the response is inadequate.

Human ALBUMIN(BHARAT SERUM) 25%:

Initial dose: The patient may require 200 to 300 mL IV to reduce edema and to bring serum protein values to normal. Since such patients usually have approximately normal blood volume, doses of more than 100 mL of Human ALBUMIN(BHARAT SERUM) 25% should not be given faster than 100 mL IV over 30 to 45 minutes to avoid circulatory overload. If slower administration is desired, 200 mL of Human ALBUMIN(BHARAT SERUM) 25% may be mixed with 300 mL of 10% dextrose solution and administered by continuous drip at a rate of 100 mL an hour IV.

Usual Adult Dose for Hypoproteinemia

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 250 or 500 mL IV at a rate of 1 to 2 mL per minute in the absence of overt shock. The capacity of the administration set is the only limit in the exsanguinated patient. The rate of infusion and total volume administered are determined by the condition and response of the patient. The initial dose may be followed by additional Human ALBUMIN(BHARAT SERUM) within 15 to 30 minutes if the response is inadequate.

Human ALBUMIN(BHARAT SERUM) 25%:

Initial dose: The patient may require 200 to 300 mL IV to reduce edema and to bring serum protein values to normal. Since such patients usually have approximately normal blood volume, doses of more than 100 mL of Human ALBUMIN(BHARAT SERUM) 25% should not be given faster than 100 mL IV over 30 to 45 minutes to avoid circulatory overload. If slower administration is desired, 200 mL of Human ALBUMIN(BHARAT SERUM) 25% may be mixed with 300 mL of 10% dextrose solution and administered by continuous drip at a rate of 100 mL an hour IV.

Usual Adult Dose for Postoperative Human ALBUMIN(BHARAT SERUM) Loss

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 250 or 500 mL IV at a rate of 1 to 2 mL per minute in the absence of overt shock. The capacity of the administration set is the only limit in the exsanguinated patient. The rate of infusion and total volume administered are determined by the condition and response of the patient. The initial dose may be followed by additional Human ALBUMIN(BHARAT SERUM) within 15 to 30 minutes if the response is inadequate.

Human ALBUMIN(BHARAT SERUM) 25%:

Initial dose: The patient may require 200 to 300 mL IV to reduce edema and to bring serum protein values to normal. Since such patients usually have approximately normal blood volume, doses of more than 100 mL of Human ALBUMIN(BHARAT SERUM) 25% should not be given faster than 100 mL IV over 30 to 45 minutes to avoid circulatory overload. If slower administration is desired, 200 mL of Human ALBUMIN(BHARAT SERUM) 25% may be mixed with 300 mL of 10% dextrose solution and administered by continuous drip at a rate of 100 mL an hour IV.

Usual Pediatric Dose for Peritonitis

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 10 to 15 mL per pound (4.5 to 6.8 mL per kg) of body weight IV is usually adequate accompanied by close surveillance of the child.

Usual Pediatric Dose for Shock

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 10 to 15 mL per pound (4.5 to 6.8 mL per kg) of body weight IV is usually adequate accompanied by close surveillance of the child.

Usual Pediatric Dose for Pancreatitis

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 10 to 15 mL per pound (4.5 to 6.8 mL per kg) of body weight IV is usually adequate accompanied by close surveillance of the child.

Usual Pediatric Dose for Burns - External

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 10 to 15 mL per pound (4.5 to 6.8 mL per kg) of body weight IV is usually adequate accompanied by close surveillance of the child.

Usual Pediatric Dose for Hypoproteinemia

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 10 to 15 mL per pound (4.5 to 6.8 mL per kg) of body weight IV is usually adequate accompanied by close surveillance of the child.

Usual Pediatric Dose for Postoperative Human ALBUMIN(BHARAT SERUM) Loss

Human ALBUMIN(BHARAT SERUM) 5%:

Initial dose: 10 to 15 mL per pound (4.5 to 6.8 mL per kg) of body weight IV is usually adequate accompanied by close surveillance of the child.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

When undiluted Human ALBUMIN(BHARAT SERUM) 25% solution is administered to patients with normal blood volume, the rate of infusion should be slow enough (1 mL per minute) to prevent too rapid expansion of plasma volume.

The amount of Human ALBUMIN(BHARAT SERUM) and duration of therapy in the treatment of shock should be based on the responsiveness of the patient as indicated by blood pressure, degree of pulmonary congestion, and hematocrit. The initial dose may be followed by additional Human ALBUMIN(BHARAT SERUM) within 15 to 30 minutes if the response is inadequate. If there is continued loss of protein, it may be desirable to give packed red blood cells.

In the treatment of burns, an optimal regimen using Human ALBUMIN(BHARAT SERUM), crystalloids, electrolytes, and water has not been established. Suggested therapy during the first 24 hours includes administration of large volumes of crystalloid solution to maintain an adequate plasma volume. Continuation of therapy beyond 24 hours usually requires more Human ALBUMIN(BHARAT SERUM) and less crystalloid solution to prevent marked hemoconcentration and maintain electrolyte balance. Duration of treatment varies depending upon the extent of protein loss through renal excretion, denuded areas of skin, and decreased Human ALBUMIN(BHARAT SERUM) synthesis. Attempts to raise the Human ALBUMIN(BHARAT SERUM) level above 4 g/100 mL may only result in an increased rate of catabolism.

Precautions

When dosing Human ALBUMIN(BHARAT SERUM), the 5% solution should be used in hypovolemic patients or intravascularly-depleted patients and the 25% solution should be used in patients in whom fluid and sodium intake is restricted.

Additional fluids should accompany or follow the administration of Human ALBUMIN(BHARAT SERUM) if the patient is dehydrated.

Administration of large quantities of Human ALBUMIN(BHARAT SERUM) should be supplemented with or replaced by packed red blood cells to combat the relative anemia which would follow such use.

Human ALBUMIN(BHARAT SERUM) should be administered with caution to patients with low cardiac reserve or with no Human ALBUMIN(BHARAT SERUM) deficiency because a rapid increase in plasma volume may cause circulatory compromise (e.g., hypertension, hypotension, or pulmonary edema). In cases of hypertension, a slower rate of administration is desired: 200 mL of Human ALBUMIN(BHARAT SERUM) solution may be mixed with 300 mL of 10% dextrose solution and administered at a rate of 10 g of Human ALBUMIN(BHARAT SERUM) (100 mL) per hour.

No clinical studies using Human ALBUMIN(BHARAT SERUM) 25% have been conducted in pediatric patients. Safety and effectiveness in pediatric patients (less than 18 years old) have not been established. However, extensive experience suggests that children respond to Human ALBUMIN(BHARAT SERUM) 25% in the same manner as adults.

Dialysis

Data not available

Other Comments

The manufacturer does not recommend diluting Human ALBUMIN(BHARAT SERUM) 5% solution.

Human ALBUMIN(BHARAT SERUM) 25% may be given intravenously without dilution or it may be diluted with normal saline or 5% dextrose before administration (200 mL per liter gives a solution which is approximately isotonic and iso-osmotic with citrated plasma).

Human ALBUMIN(BHARAT SERUM), unlike whole blood or plasma, is considered free of the danger of homologous serum hepatitis. Human ALBUMIN(BHARAT SERUM) may be given in conjunction with other parenteral fluids such as saline, dextrose, or sodium lactate. It is convenient to use since no cross-matching is required and the absence of cellular elements removes the danger of sensitization with repeated infusions.

Human ALBUMIN(BHARAT SERUM) human solution is compatible with whole blood or packed red blood cells as well as the usual electrolyte and carbohydrate solutions intended for intravenous use. Human ALBUMIN(BHARAT SERUM) should not be mixed with protein hydrolysates, amino acid mixtures, or solutions containing alcohol. It is ready for use as contained in the bottle and may be given without regard to the blood group of the patient.

Human ALBUMIN(BHARAT SERUM) interactions

See also:
What other drugs will affect Human ALBUMIN(BHARAT SERUM)?

sponsored

There are no known significant interactions.

Human ALBUMIN(BHARAT SERUM) side effects

See also:
What are the possible side effects of Human ALBUMIN(BHARAT SERUM)?

General

The most serious events are anaphylactic shock, circulatory failure, cardiac failure, and pulmonary edema.

The most common adverse events are anaphylactoid type of reactions.

Adverse reactions for Human ALBUMIN(BHARAT SERUM) (Human) 20% normally resolve when the infusion rate is slowed down or the infusion is stopped. In case of severe reactions, the infusion should be stopped and appropriate treatment should be initiated.

Clinical Studies Experience

No clinical studies were done using Human ALBUMIN(BHARAT SERUM) (Human) 20%

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of Human ALBUMIN(BHARAT SERUM) (HUMAN) (any strength). Because these reactions are reported voluntarily from a population of unknown size, it is not always possible to reliably estimate their frequency.

Table 1 Adverse reactions observed for Human ALBUMIN(BHARAT SERUM) HUMAN (any strength) during post-marketing phase (in decreasing order of severity)

No drug interaction studies have been conducted.

Human ALBUMIN(BHARAT SERUM) contraindications

See also:
What is the most important information I should know about Human ALBUMIN(BHARAT SERUM)?

Hypersensitivity to Human ALBUMIN(BHARAT SERUM) or any component of the formulation; severe anemia, heart failure; patients at risk of volume overload (eg, patients with renal insufficiency, severe anemia, stabilized chronic anemia, or heart failure); dilution with sterile water for injection (may cause hemolysis or acute renal failure)

Active ingredient matches for Human ALBUMIN(BHARAT SERUM):

Albumin


Unit description / dosage (Manufacturer)Price, USD
HUMAN ALBUMIN 20% INFUSION 1 bottle / 100 ML infusion each (Bharat Serums & Vaccines Ltd)$ 60.24

List of Human ALBUMIN(BHARAT SERUM) substitutes (brand and generic names):

Injectable; Injection; Albumin Human 10%
Injectable; Injection; Albumin Human 5%
Injectable; Injection; Albumin Human 20%
Injectable; Injection; Albumin Human 25%
ALBUMIN 20% INJECTION 1 vial / 1 injection each (Bayer Pharmaceuticals Pvt Ltd)$ 19.58
ALBUMIN-GRIFOLS 20% PREFILLED SYRINGE 1 packet / 100 ML prefilled syringe each (Bharat Serums & Vaccines Ltd)$ 84.34
Albuprime 20% Injection (Intas Pharmaceuticals Ltd)$ 0.54
Alburel-T 20gm Injection (Reliance Life Sciences)$ 0.55
Albutas 20% Injection (Intas Pharmaceuticals Ltd)$ 0.51
HUMAN ALBUMIN 5% INFUSION 1 bottle / 100 ML infusion each (Serum Institute Of India Ltd)$ 41.79
OPV Drops / NA / 10 x 10 units (Aventis pasteur)$ 8.77
10's (Aventis pasteur)$ 8.77
OPV INJECTION 1 vial / 1 injection each (Aventis pasteur)$ 2.77
Relab 20 % x 1 Bottle 100 mL
Relab 20 % x 1 Bottle 50 mL

Reviews

The results of a survey conducted on ndrugs.com for Human ALBUMIN(BHARAT SERUM) are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Human ALBUMIN(BHARAT SERUM). We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


Consumer reported time for results

No survey data has been collected yet


Consumer reported age

No survey data has been collected yet


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 22 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2024 ndrugs.com All Rights Reserved